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Home / Equine Research Bank / Anim Genet / A genome-wide association study indicates LCORL/NCAPG as a c...
Animal genetics2013; 44(4); 467-471; doi: 10.1111/age.12031

A genome-wide association study indicates LCORL/NCAPG as a candidate locus for withers height in German Warmblood horses.

Abstract: A genome-wide association scan for loci affecting withers height was conducted in 782 German Warmblood stallions, which were genotyped using the Illumina EquineSNP50 Bead Chip. A principal components approach was applied to correct for population structure. The analysis revealed a single major QTL on ECA3 explaining ~18 per cent of the phenotypic variance, which is in concordance with recent reports from other horse populations. The LCORL/NCAPG locus represents a strong candidate gene for this QTL. This locus is among a small number that have consistently been identified to influence human height in several large meta-analyses. Furthermore, a mutation within the NCAPG gene was found to affect growth and body frame size in cattle. Together with the results of this study in German Warmbloods, these findings strongly indicate LCORL/NCAPG as a candidate locus for withers height in horses. Further studies are, however, needed to confirm this.
© 2013 The Authors, Animal Genetics © 2013 Stichting International Foundation for Animal Genetics.
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Publication Date: 2013-02-18 PubMed ID: 23418885DOI: 10.1111/age.12031Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research focuses on finding genetic influences on the height of German Warmblood stallions. A major gene location (LCORL/NCAPG) was identified that could be responsible for 18% of the height variance observed in these horses.

Research Methodology

  • The researchers conducted a genome-wide association scan on 782 German Warmblood stallions to find genes affecting their withers height (height at the base of the neck).
  • The horses were genotyped using the Illumina EquineSNP50 Bead Chip, a technology that allows for comprehensive genomic coverage.
  • To correct for population structure, a principal components approach was applied – a statistical method that transforms possible correlated variables into uncorrelated variables called principal components.

Findings

  • The analysis led to the identification of a major Quantitative Trait Locus (QTL) on ECA3. QTL is a region in the DNA which correlates with variation in a phenotype (in this case, the height of the horse). The ECA3 refers to a specific location in the horse’s chromosomes.
  • This QTL explains about 18% of the phenotypic difference in height between the horses.
  • The identified gene location – LCORL/NCAPG – is a strong candidate gene for this QTL. This gene locus has been consistently found to influence human height in several large meta-analyses.
  • A mutation within the NCAPG gene is found to affect growth and body frame size in cattle, supporting the premise that LCORL/NCAPG could influence height in horses as well.

Implications and Future Research

  • This study provides strong evidence that the LCORL/NCAPG gene locus may influence withers height in German Warmblood horses.
  • This finding could be helpful for breeders focusing on withers height in their breeding programs.
  • Further studies are needed to confirm the role of this gene location on withers height in horses.

Cite This Article

APA
Tetens J, Widmann P, Kühn C, Thaller G. (2013). A genome-wide association study indicates LCORL/NCAPG as a candidate locus for withers height in German Warmblood horses. Anim Genet, 44(4), 467-471. https://doi.org/10.1111/age.12031

Publication

Animal genetics
ISSN: 1365-2052
NlmUniqueID: 8605704
Country: England
Language: English
Volume: 44
Issue: 4
Pages: 467-471

Researcher Affiliations

Tetens, J
  • Institute of Animal Breeding and Husbandry, Christian-Albrechts-University Kiel, Hermann-Rodewald-Str. 6, D-24118 Kiel, Germany. jtetens@tierzucht.uni-kiel.de
Widmann, P
    Kühn, C
      Thaller, G

        MeSH Terms

        • Animals
        • Biometry
        • Breeding
        • Chromosome Mapping / veterinary
        • Chromosomes, Mammalian / genetics
        • Genetic Loci
        • Genome-Wide Association Study / methods
        • Genome-Wide Association Study / veterinary
        • Genotype
        • Horses / anatomy & histology
        • Horses / genetics
        • Horses / growth & development
        • Male
        • Mutation
        • Polymorphism, Single Nucleotide
        • Quantitative Trait Loci / genetics

        Citations

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