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Equine veterinary journal1993; 25(1); 65-68; doi: 10.1111/j.2042-3306.1993.tb02904.x

Advancing the time of ovulation in the mare with a short-term implant releasing the GnRH analogue deslorelin.

Abstract: A small, biocompatible and short-term implant releasing 1.5 mg or 2.25 mg of the GnRH analogue deslorelin was evaluated in 140 Hanoverian (warm blooded) mares during the 1990 breeding season (Study I). Mares in oestrus and with a follicle 40 +/- 2 mm in diameter were assigned alternately to treatment (70) or remained as untreated controls. Implants were administered subcutaneously, and intervals to ovulation determined by rectal examination and ultrasound at 12-h intervals. Since results with both doses of deslorelin were similar, data were pooled. Deslorelin implantation resulted in ovulations in 65 of 70 mares within 48 h (93%), while only 5 of 70 control mares ovulated within the same time period (7%) (P < 0.01). Most induced ovulations (63%) occurred 36-48 h after implantation. In Study II, 4 groups of 12 Hanoverian mares each were treated with 3,000 or 5,000 iu hCG, or a 2.25 mg deslorelin implant, or received placebo. All treatments resulted in 100% ovulations within 48 h, versus 25% ovulations in controls (P < 0.01), and 63%, 75% and 86% of these ovulations occurred 36-48 h after treatment with 3,000 and 5,000 iu hCG and deslorelin respectively. Hormonal response to deslorelin in treated mares, sampled every 12 h, consisted of elevations of FSH and LH concentrations of > 200% and > 300% baseline values at 12 h (P < 0.001), of 67% and 79% at 24 h (P < 0.01) and of 35% and 49% at 48 h (P < 0.05), respectively. No local reactions at the implantation site were observed.
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Publication Date: 1993-01-01 PubMed ID: 8422889DOI: 10.1111/j.2042-3306.1993.tb02904.xGoogle Scholar: Lookup
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  • Comparative Study
  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article evaluates the impact of a short-term implant releasing the GnRH analogue deslorelin on advancing the time of ovulation in Hanoverian mares. The results indicate the implantation had a significant effect in triggering ovulation within 48 hours, and suggests a potential application in breeding and equine reproduction management.

Study Design and Procedure

  • The study was divided into two separate experiments, Study I and Study II, conducted during the 1990 breeding season.
  • Study I included 140 Hanoverian mares (warm blooded) that were either assigned to a treatment group that received 1.5 mg or 2.25 mg of the GnRH analogue deslorelin implant, or to a control group that received no treatment.
  • Study II had four groups of 12 Hanoverian mares each, treated with doses of hCG, a 2.25 mg deslorelin implant, or a placebo. The response to treatment was then observed.
  • All mares in the study were in oestrus and each had a follicle 40 +/- 2 mm in diameter.
  • Deslorelin implants were administered subcutaneously, and intervals to ovulation were then determined by rectal examination and use of ultrasound at 12-hour intervals.

Results and Observations

  • In Study I, deslorelin implantation resulted in 93% of mares ovulating within 48 hours as compared to only 7% in the control group.
  • Between 36-48 hours after implantation, 63% of the induced ovulations occurred.
  • In Study II, all treatments led to 100% ovulation within 48 hours, versus 25% ovulation in controls, with deslorelin showing the highest percentage (86%) of ovulations between 36-48 hours post treatment.
  • Deslorelin-treated mares showed elevated levels of FSH and LH hormones over the 48 hour period post implantation.
  • No local reactions were observed at the implantation site, indicating the biocompatibility of the implant.

Implications

  • This study suggests that deslorelin could potentially be used to manage and control the timing of ovulation in mares, which is of significant importance in equine breeding practices.
  • The elevation of FSH and LH hormones is indicative of the effect of deslorelin on triggering hormonal changes necessary for ovulation.
  • The absence of adverse local reactions emphasizes the safety and biocompatibility of the deslorelin implant.

Cite This Article

APA
Meinert C, Silva JF, Kroetz I, Klug E, Trigg TE, Hoppen HO, Jöchle W. (1993). Advancing the time of ovulation in the mare with a short-term implant releasing the GnRH analogue deslorelin. Equine Vet J, 25(1), 65-68. https://doi.org/10.1111/j.2042-3306.1993.tb02904.x

Publication

Equine veterinary journal
ISSN: 0425-1644
NlmUniqueID: 0173320
Country: United States
Language: English
Volume: 25
Issue: 1
Pages: 65-68

Researcher Affiliations

Meinert, C
  • Equine A.I. Center, Landgestüt Celle, Germany.
Silva, J F
    Kroetz, I
      Klug, E
        Trigg, T E
          Hoppen, H O
            Jöchle, W

              MeSH Terms

              • Alcohol Dehydrogenase / antagonists & inhibitors
              • Animals
              • Chorionic Gonadotropin / pharmacology
              • Drug Implants
              • Female
              • Follicle Stimulating Hormone / blood
              • Gonadotropin-Releasing Hormone / administration & dosage
              • Gonadotropin-Releasing Hormone / analogs & derivatives
              • Gonadotropin-Releasing Hormone / pharmacology
              • Horses / physiology
              • Luteinizing Hormone / blood
              • Ovulation / drug effects
              • Progesterone / blood
              • Time Factors
              • Triptorelin Pamoate / analogs & derivatives

              Citations

              This article has been cited 4 times.
              1. Fanelli D, Tesi M, Rota A, Beltramo M, Conte G, Giorgi M, Barsotti G, Camillo F, Panzani D. hCG is more effective than the GnRH agonist buserelin for inducing the first ovulation of the breeding season in mares. Equine Vet J 2022 Mar;54(2):306-311.
                doi: 10.1111/evj.13455pubmed: 33884659google scholar: lookup
              2. McKenna J, Bellofiore N, Catt S, Pangestu M, Temple-Smith P. A human-based assisted reproduction protocol for the menstruating spiny mouse, Acomys cahirinus. PLoS One 2020;15(12):e0244411.
                doi: 10.1371/journal.pone.0244411pubmed: 33370773google scholar: lookup
              3. Camillo F, Pacini M, Panzani D, Vannozzi I, Rota A, Aria G. Clinical use of twice daily injections of buserelin acetate to induce ovulation in the mare. Vet Res Commun 2004 Aug;28 Suppl 1:169-72.
                doi: 10.1023/b:verc.0000045398.62134.e4pubmed: 15372949google scholar: lookup
              4. Gånheim A, Gånheim A, Jöchle W. Acceleration and timing of fertile ovulation in cyclic mares with a deslorelin implant. Acta Vet Scand 1995;36(4):393-400.
                doi: 10.1186/BF03547654pubmed: 8669367google scholar: lookup
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