Omneity® Pellets
All-In-One Vitamin & Mineral Pellet
Anthelmintic drug resistance in the UK.
Abstract: The term 'anthelmintic drug resistance' describes the heritable ability of some nematode parasites to survive treatment with anthelmintic drugs at the recommended therapeutic dose levels. Genes for resistance appear to be present in many of the important pathogenic nematodes of ruminants and horses. Under intensive management systems, where heavy reliance is placed on anthelmintic drugs for worm control, the selection of resistant genotypes may result in increased reports of the drugs failing to control the nematode populations against which they are aimed. Anthelmintic resistance has been reported from many parts of the world, and in some countries multiple drug-resistant strains have emerged. In the UK, recent investigations indicate an increasing level of resistance to benzimidazoles among nematodes of sheep and horses. The incidence, diagnosis, epidemiology and implications of anthelmintic resistance are discussed.
Publication Date: 1989-08-12 PubMed ID: 2678722DOI: 10.1136/vr.125.7.143Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
- Review
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research article explores the increasing resistance to deworming drugs in nematode parasites within the UK, especially those affecting ruminant and equine species.
Understanding Anthelmintic Drug Resistance
- The research revolves around ‘anthelmintic drug resistance’. This phrase refers to the inherited ability of certain nematode parasites to resist treatment with anthelmintic drugs. These drugs are designed to eradicate parasitic worms, and resistance to them implies that nematodes can survive even when subjected to the recommended therapeutic dosage.
- What makes this resistance worrisome is that the genes contributing to this resistance are present in numerous crucial pathogenic nematodes. These nematodes affect ruminants (animals like cattle, sheep, goats – known for their ability to ferment plant-based food in a specialized stomach prior to digestion) and horses.
Impact of Intensive Management Systems
- The paper also discusses the role of intensive management systems, where anthelmintic drugs are heavily relied upon for worm control. This dependence facilitates the selection and spread of resistant nematode genotypes, making it increasingly harder to control the target nematode population with these drugs.
Global Perspective of Anthelmintic Drug Resistance
- The problem of anthelmintic resistance is not restricted to the UK alone. The paper references resistance reports from various parts of the world, and in some cases, strains of nematodes that exhibit resistance to multiple drugs have emerged.
The Situation in the UK
- The UK is seeing a growing level of resistance, particularly among nematodes in sheep and horses, to benzimidazoles – a class of anthelmintic drugs.
Discussion of Incidence, Diagnosis, and Epidemiology
- Lastly, the paper delves into discussing the incidence, diagnosis, and epidemiology of anthelmintic resistance. It also explores the broader implications of this resistance, giving the issue a well-rounded examination.
Cite This Article
APA
Taylor MA, Hunt KR.
(1989).
Anthelmintic drug resistance in the UK.
Vet Rec, 125(7), 143-147.
https://doi.org/10.1136/vr.125.7.143 Publication
Researcher Affiliations
- Parasitology Department, Central Veterinary Laboratory, New Haw, Weybridge.
MeSH Terms
- Animals
- Anthelmintics / pharmacology
- Anthelmintics / therapeutic use
- Benzimidazoles / pharmacology
- Benzimidazoles / therapeutic use
- Drug Resistance / genetics
- Horses / parasitology
- Nematoda / drug effects
- Nematoda / genetics
- Nematode Infections / drug therapy
- Nematode Infections / veterinary
- Sheep / parasitology
- United Kingdom
References
This article includes 70 references
Citations
This article has been cited 10 times.- Babják M, Königová A, Várady M. Multiple Anthelmintic Resistance at a Goat Farm in Slovakia. Helminthologia 2021 Jun;58(2):173-178.
- Mohammedsalih KM, Krücken J, Bashar A, Juma FR, Abdalmalaik AAH, Khalafalla A, Abakar A, Coles G, von Samson-Himmelstjerna G. Susceptible trichostrongyloid species mask presence of benzimidazole-resistant Haemonchus contortus in cattle. Parasit Vectors 2021 Feb 8;14(1):101.
- George MM, Lopez-Soberal L, Storey BE, Howell SB, Kaplan RM. Motility in the L3 stage is a poor phenotype for detecting and measuring resistance to avermectin/milbemycin drugs in gastrointestinal nematodes of livestock. Int J Parasitol Drugs Drug Resist 2018 Apr;8(1):22-30.
- Keane OM, Keegan JD, Good B, de Waal T, Fanning J, Gottstein M, Casey M, Hurley C, Sheehan M. High level of treatment failure with commonly used anthelmintics on Irish sheep farms. Ir Vet J 2014;67(1):16.
- Shalaby HA. Anthelmintics Resistance; How to Overcome it?. Iran J Parasitol 2013 Jan;8(1):18-32.
- Garg R, Kumar RR, Yadav CL, Banerjee PS. Duration of anthelmintic effect of three formulations of ivermectin (oral, injectable and pour-on) against multiple anthelmintic-resistant haemonchus contortus in sheep. Vet Res Commun 2007 Aug;31(6):749-55.
- Königová A, Várady M, Corba J. Comparison of in vitro methods and faecal egg count reduction test for the detection of benzimidazole resistance in small strongyles of horses. Vet Res Commun 2003 May;27(4):281-8.
- Geerts S, Gryseels B. Drug resistance in human helminths: current situation and lessons from livestock. Clin Microbiol Rev 2000 Apr;13(2):207-22.
- Waruiru RM, Weda EH, Otieno RO, Ngotho JW, Bøgh HO. Comparative efficacies of closantel, ivermectin, oxfendazole, thiophanate and levamisole against thiabendazole resistant Haemonchus contortus in sheep. Trop Anim Health Prod 1996 Aug;28(3):216-20.
- Rahman WA. Survey for drug-resistant trichostrongyle nematodes in ten commercial goat farms in west Malaysia. Trop Anim Health Prod 1994 Nov;26(4):235-8.
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists
