FREE SHIPPING over $40
OVER 10000 FIVE-STAR REVIEWS
5% OFF ALL SUBSCRIPTIONS
100% HAPPINESS GUARANTEE
Analyze Diet
0
Peptides2021; 142; 170576; doi: 10.1016/j.peptides.2021.170576

Antimicrobial peptides in domestic animals and their applications in veterinary medicine.

Abstract: Antimicrobial peptides (AMPs) are molecules with a broad-spectrum activity against bacteria, fungi, protozoa, and viruses. These peptides are widely distributed in insects, amphibians and mammals. Indeed, they are key molecules of the innate immune system with remarkable antimicrobial and immunomodulatory activity. Besides, these peptides have also shown regulatory activity for gut microbiota and have been considered inductors of growth performance. The current review describes the updated findings of antimicrobial peptides in domestic animals, such as bovines, goats, sheep, pigs, horses, canines and felines, analyzing the most relevant aspects of their use as potential therapeutics and their applications in Veterinary medicine.
Copyright © 2021 Elsevier Inc. All rights reserved.
Get Full Text
Publication Date: 2021-05-24 PubMed ID: 34033877DOI: 10.1016/j.peptides.2021.170576Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
LinkedInCopy
  • Journal Article
  • Review

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article discusses the role and potential usages of Antimicrobial peptides (AMPs) found in domestic animals in the field of veterinary medicine. It gives an update on findings related to AMPs in various animals and explores their possibilities as therapeutic tools.

Understanding Antimicrobial Peptides (AMPs)

  • Antimicrobial peptides (AMPs) are molecules with profound abilities to combat various pathogenic organisms. They exhibit substantial activity against an array of pathogens, such as bacteria, fungi, protozoa, and viruses.
  • AMPs are naturally occurring in many species including insects, amphibians, mammals and are primarily associated as key components of the innate immune system.
  • These peptides not only offer antimicrobial properties but also present noteworthy immunomodulatory activity.
  • Apart from their central role within the immune response, AMPs also reportedly have a regulatory effect on gut microbiota – the community of microorganisms living in the digestive tracts of animals. This aspect has led to AMPs being considered as potential growth performance inducers.

AMPs in Domestic Animals

  • The paper reviews current research and information on the presence and usage of AMPs in domestic animals such as cows, goats, sheep, pigs, horses, dogs, and cats.
  • Each of these animals hosts various AMPs, each with unique qualities that could potentially be harnessed for therapeutic purposes.

Applications in Veterinary Medicine

  • The review considers the therapeutic usage of these peptides, signaling them as important potential tools in veterinary medicine.
  • AMPs could potentially be utilized as a novel treatment modality against various infectious diseases that current antibiotics may struggle against.
  • Furthermore, the immunomodulatory capabilities of AMPs could make them valuable therapeutic agents in controlling immune responses and inflammation in animals.
  • Additionally, their regulatory function on gut microbiota could mean that AMPs have a role in optimizing the health and growth performance of domestic animals.

Cite This Article

APA
Valdez-Miramontes CE, De Haro-Acosta J, Aréchiga-Flores CF, Verdiguel-Fernández L, Rivas-Santiago B. (2021). Antimicrobial peptides in domestic animals and their applications in veterinary medicine. Peptides, 142, 170576. https://doi.org/10.1016/j.peptides.2021.170576

Publication

Peptides
ISSN: 1873-5169
NlmUniqueID: 8008690
Country: United States
Language: English
Volume: 142
Pages: 170576
PII: S0196-9781(21)00084-X

Researcher Affiliations

Valdez-Miramontes, C E
  • Academic Unit of Veterinary Medicine, Autonomous University of Zacatecas, Zacatecas, Mexico. Electronic address: claudiavm@uaz.edu.mx.
De Haro-Acosta, Jeny
  • Medical Research Unit-Zacatecas, Mexican Institute for Social Security- IMSS, Zacatecas, Mexico.
Aréchiga-Flores, C F
  • Academic Unit of Veterinary Medicine, Autonomous University of Zacatecas, Zacatecas, Mexico.
Verdiguel-Fernández, L
  • Molecular Microbiology Laboratory, Department of Microbiology and Immunology, Faculty of Medicine Veterinary, National Autonomous University of Mexico, Mexico.
Rivas-Santiago, B
  • Medical Research Unit-Zacatecas, Mexican Institute for Social Security- IMSS, Zacatecas, Mexico.

MeSH Terms

  • Animals
  • Animals, Domestic
  • Anti-Infective Agents / pharmacology
  • Antimicrobial Peptides / pharmacology
  • Immunomodulation
  • Veterinary Medicine

Citations

This article has been cited 24 times.
  1. Lach J, Krupińska M, Mikołajczyk A, Strapagiel D, Stączek P, Matera-Witkiewicz A. Novel Antimicrobial Peptides from Saline Environments Active against E. faecalis and S. aureus: Identification, Characterisation and Potential Usage. Int J Mol Sci 2023 Jul 22;24(14).
    doi: 10.3390/ijms241411787pubmed: 37511545google scholar: lookup
  2. Phuong HBT, Tran VA, Ngoc KN, Huu VN, Thu HN, Van MC, Thi HP, Hong MN, Tran HT, Xuan HL. Effect of substituting glutamine with lysine on structural and biological properties of antimicrobial peptide Polybia-MP1. Amino Acids 2023 Jul;55(7):881-890.
    doi: 10.1007/s00726-023-03276-3pubmed: 37300579google scholar: lookup
  3. Jacobo-Delgado YM, Rodríguez-Carlos A, Serrano CJ, Rivas-Santiago B. Mycobacterium tuberculosis cell-wall and antimicrobial peptides: a mission impossible?. Front Immunol 2023;14:1194923.
    doi: 10.3389/fimmu.2023.1194923pubmed: 37266428google scholar: lookup
  4. Ou Y, Zhuang H, Chen R, Huang D, Wang C. Secretory Expression and Application of Antilipopolysaccharide Factor 3 in Chlamydomonas reinhardtii. Bioengineering (Basel) 2023 May 8;10(5).
    doi: 10.3390/bioengineering10050564pubmed: 37237634google scholar: lookup
  5. Zhang LM, Yang M, Zhou SW, Zhang H, Feng Y, Shi L, Li DS, Lu QM, Zhang ZH, Zhao M. Blapstin, a Diapause-Specific Peptide-Like Peptide from the Chinese Medicinal Beetle Blaps rhynchopetera, Has Antifungal Function. Microbiol Spectr 2023 Jun 15;11(3):e0308922.
    doi: 10.1128/spectrum.03089-22pubmed: 37140456google scholar: lookup
  6. Woszczyło M, Pasikowski P, Devaraj S, Kokocińska A, Szumny A, Skwark MJ, Niżański W, Dzięcioł M. Urinary Proteins of Female Domestic Dog (Canis familiaris) during Ovarian Cycle. Vet Sci 2023 Apr 14;10(4).
    doi: 10.3390/vetsci10040292pubmed: 37104448google scholar: lookup
  7. Hiller S, Kowalewska I, Czerniawska-Piątkowska E, Banaszewska D. Analysis of the Effect of Polymorphisms within the CATHL7 Gene on Dairy Performance Parameters. J Vet Res 2023 Mar;67(1):123-129.
    doi: 10.2478/jvetres-2023-0018pubmed: 37008775google scholar: lookup
  8. He S, Yang K, Wen J, Kuang T, Cao Z, Zhang L, Han S, Jian S, Chen X, Zhang L, Deng J, Deng B. Antimicrobial Peptides Relieve Transportation Stress in Ragdoll Cats by Regulating the Gut Microbiota. Metabolites 2023 Feb 22;13(3).
    doi: 10.3390/metabo13030326pubmed: 36984766google scholar: lookup
  9. Contreras MJ, Núñez-Montero K, Bruna P, García M, Leal K, Barrientos L, Weber H. Bacteria and Boar Semen Storage: Progress and Challenges. Antibiotics (Basel) 2022 Dec 10;11(12).
    doi: 10.3390/antibiotics11121796pubmed: 36551453google scholar: lookup
  10. Wu D, Fu L, Wen W, Dong N. The dual antimicrobial and immunomodulatory roles of host defense peptides and their applications in animal production. J Anim Sci Biotechnol 2022 Dec 6;13(1):141.
    doi: 10.1186/s40104-022-00796-ypubmed: 36474280google scholar: lookup
  11. Yan Y, Niu Y, Ma Y, Zhao X, Pan M, Ma B, Wei Q. Estradiol Regulates the Expression and Secretion of Antimicrobial Peptide S100A7 via the ERK1/2-Signaling Pathway in Goat Mammary Epithelial Cells. Animals (Basel) 2022 Nov 8;12(22).
    doi: 10.3390/ani12223077pubmed: 36428305google scholar: lookup
  12. Machuka EM, Juma J, Muigai AWT, Amimo JO, Pelle R, Abworo EO. Transcriptome profile of spleen tissues from locally-adapted Kenyan pigs (Sus scrofa) experimentally infected with three varying doses of a highly virulent African swine fever virus genotype IX isolate: Ken12/busia.1 (ken-1033). BMC Genomics 2022 Jul 19;23(1):522.
    doi: 10.1186/s12864-022-08754-8pubmed: 35854219google scholar: lookup
  13. Nejfeld R, Chrobak-Chmiel D, Kwiecień E, Stefańska I, Mordzińska K, Rzewuska M, Gieryńska M. Alternative approaches in combating antimicrobial resistance in animals. Arch Microbiol 2026 Mar 10;208(5).
    doi: 10.1007/s00203-026-04803-ypubmed: 41806028google scholar: lookup
  14. Rzycki M, Gruda A. Designing AI-generated antimicrobials for targeting bacterial microdomains. Sci Rep 2025 Dec 9;16(1):1708.
    doi: 10.1038/s41598-025-31350-1pubmed: 41366002google scholar: lookup
  15. da Silva EM, Cipelli M, do Amaral MA, Pacheco-Silva A, Câmara NOS, Andrade-Oliveira V. Downregulation of Enteroendocrine Genes Predicts Survival in Colon Cancer: A Bioinformatics-Based Analysis. Int J Mol Sci 2025 Nov 18;26(22).
    doi: 10.3390/ijms262211127pubmed: 41303610google scholar: lookup
  16. Marciano CL, Félix de Lima JV, Couto Rosa MSD, do Nascimento RA, Ferraz AO, Silva ICD, Chrysostomo-Massaro TN, Rosa-Garzon NGD, Cabral H. A Comprehensive Overview of Antimicrobial Peptides: Broad-Spectrum Activity, Computational Approaches, and Applications. Antibiotics (Basel) 2025 Nov 5;14(11).
    doi: 10.3390/antibiotics14111115pubmed: 41301610google scholar: lookup
  17. Alabi MA, Chenia HY, Lin J. Antibiotic Use in Livestock: A Driver of Resistance in Africa and the Path to Safer Alternatives. Microbiologyopen 2025 Dec;14(6):e70122.
    doi: 10.1002/mbo3.70122pubmed: 41214790google scholar: lookup
  18. Giugliano R, Zannella C, Chianese A, Acconcia C, Monti A, Della Marca R, Pagnini U, Montagnaro S, Doti N, Isernia C, Galdiero M, Fiorito F, Russo L, Iovane V, De Filippis A. Pantinin-Derived Peptides against Veterinary Herpesviruses: Activity and Structural Characterization. ChemMedChem 2025 Oct 6;20(19):e202500333.
    doi: 10.1002/cmdc.202500333pubmed: 40946226google scholar: lookup
  19. Asghari Baghkheirati A, Golmohammadi R, Sekhavati MH, Razmyar J, Abyazi MA. Recombinant Antimicrobial Peptides (rAMPs); Potential Applications in Medicine and Veterinary Medicine: A Review. Iran J Biotechnol 2024 Oct;22(4):e3913.
    doi: 10.30498/ijb.2024.455700.3913pubmed: 40225299google scholar: lookup
  20. Zhang Q, Choi K, Wang X, Xi L, Lu S. The Contribution of Human Antimicrobial Peptides to Fungi. Int J Mol Sci 2025 Mar 11;26(6).
    doi: 10.3390/ijms26062494pubmed: 40141139google scholar: lookup
  21. Li B, Liu M, Du W, Wang S, Xu Z, Zhang X, Zhang Y, Hua S. Cecropin AD ameliorates pneumonia and intestinal injury in mice with mycoplasma pneumoniae by mediating gut microbiota. BMC Vet Res 2025 Jan 29;21(1):39.
    doi: 10.1186/s12917-025-04500-wpubmed: 39881281google scholar: lookup
  22. He H, Fang C, Liu L, Li M, Liu W. Environmental Driving of Adaptation Mechanism on Rumen Microorganisms of Sheep Based on Metagenomics and Metabolomics Data Analysis. Int J Mol Sci 2024 Oct 11;25(20).
    doi: 10.3390/ijms252010957pubmed: 39456741google scholar: lookup
  23. Hao S, Shi W, Chen L, Kong T, Wang B, Chen S, Guo X. CATH-2-derived antimicrobial peptide inhibits multidrug-resistant Escherichia coli infection in chickens. Front Cell Infect Microbiol 2024;14:1390934.
    doi: 10.3389/fcimb.2024.1390934pubmed: 38812753google scholar: lookup
  24. Shea Z, Ogando do Granja M, Fletcher EB, Zheng Y, Bewick P, Wang Z, Singer WM, Zhang B. A Review of Bioactive Compound Effects from Primary Legume Protein Sources in Human and Animal Health. Curr Issues Mol Biol 2024 May 1;46(5):4203-4233.
    doi: 10.3390/cimb46050257pubmed: 38785525google scholar: lookup
Subscribe to our newsletter
Join 99,493 horse owners like you who receive our email updates on horse health and nutrition.