Assessment of serum allergen-specific IgE levels in horses with seasonal allergic dermatitis and recurrent airway obstruction in Spain.
Abstract: Allergic conditions are prevalent equine diseases that can be diagnosed by clinical examination alone, but definitive diagnosis is more likely with laboratory testing. The ELISA Allercept© test was used to analyse the serum samples of 73 horses with allergic diseases. Sixty-one horses (83.5%) had allergen-specific IgE levels ≥ 150 ELISA Units (EU), the cut-off defined by the assay. Fifty-four horses had allergic dermatitis (AD) with high IgE levels to Tyrophagus putrescentiae (51.9%), Rumex crispus (48.1%), Tabanus (46.3%) and Dermatophagoides farinae/ D. pteronyssinus (40.7%). Seven horses with recurrent airway obstruction (RAO) had a high prevalence of T. putrescentiae (85.7%), followed by that of Acarus siro (57.1%) and D. farinae/D. pteronyssinus (57.1%). Horses affected with RAO had more positive reactions to mites (2.22 ± 0.84) than did horses with AD (1.51 ± 0.61, P < 0.05). A strong correlation of serum allergen-specific IgE level was found between Culex tarsalis and Stomoxys (r = 0.943) and between Dactylis glomerata and both Secale cereale (r = 0.79) and R. crispus (r = 0.696). These results indicate that among horses with allergic diseases in Spain, ELISA tests demonstrated a high prevalence of serum allergen-specific IgE in response to mites. Our study emphasises the importance of laboratory testing and updating allergy panels to improve the likelihood of a definitive diagnosis and the identification of allergens that should be included in allergic disease treatment.
Publication Date: 2019-03-30 PubMed ID: 30922098DOI: 10.1556/004.2019.002Google Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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This study examined the levels of allergen-specific IgE in the serum of horses suffering from seasonal allergic dermatitis and recurrent airway obstruction in Spain. The research revealed that a majority of these horses responded strongly to certain allergens, highlighting the importance of using laboratory testing for a more accurate diagnosis.
Methodology
- Researchers conducted an analysis of serum samples taken from 73 horses diagnosed with allergic diseases.
- They used the ELISA Allercept© test to measure the levels of serum allergen-specific IgE, a type of antibody that is typically associated with allergic reactions.
- A cut-off level of 150 ELISA Units (EU) was used for the IgE levels as per the assay’s definition.
Results
- 61 of the 73 horses, translating to approximately 83.5%, showed IgE levels above the 150 EU cut-off, clearly indicating allergic conditions.
- Amongst the 54 horses diagnosed with allergic dermatitis (AD), high levels of IgE were detected in response to several allergens.
- The study revealed that horses with recurrent airway obstruction (RAO) had notably higher reactions to mites – these horses showed more positive reactions to mites than the ones suffering from allergic dermatitis.
Correlations and Conclusions
- The study showed strong correlations between the IgE level response of horses to certain pairs of allergens.
- The results confirmed a high prevalence of allergen-specific serum IgE levels in response to mites among horses in Spain suffering from allergic diseases.
- The research underpinned the importance of lab testing and periodic updating of allergy panels to enhance the probability of making a definitive diagnosis and to identify allergens for inclusion in the treatment plan.
Cite This Article
APA
Marteles D, Odriozola L, Verde MT, Conde T, Fernández A.
(2019).
Assessment of serum allergen-specific IgE levels in horses with seasonal allergic dermatitis and recurrent airway obstruction in Spain.
Acta Vet Hung, 67(1), 11-21.
https://doi.org/10.1556/004.2019.002 Publication
Researcher Affiliations
- Animal Pathology Department, Veterinary Faculty, Zaragoza University , Miguel Servet 177, 50013 Zaragoza , Spain.
- Animal Pathology Department, Veterinary Faculty, Zaragoza University , Miguel Servet 177, 50013 Zaragoza , Spain.
- Animal Pathology Department, Veterinary Faculty, Zaragoza University , Miguel Servet 177, 50013 Zaragoza , Spain.
- Animal Pathology Department, Veterinary Faculty, Zaragoza University , Miguel Servet 177, 50013 Zaragoza , Spain.
- Animal Pathology Department, Veterinary Faculty, Zaragoza University , Miguel Servet 177, 50013 Zaragoza , Spain.
MeSH Terms
- Airway Obstruction / epidemiology
- Airway Obstruction / immunology
- Airway Obstruction / veterinary
- Allergens / immunology
- Animals
- Antibody Specificity / physiology
- Dermatitis, Atopic / immunology
- Dermatitis, Atopic / veterinary
- Horse Diseases / immunology
- Horses
- Immunoglobulin E / immunology
- Insect Bites and Stings / immunology
- Insect Bites and Stings / veterinary
- Pollen
- Seasons
- Spain / epidemiology
Citations
This article has been cited 1 times.- Di Tommaso M, Luciani A, Crisi PE, Beschi M, Rosi P, Rocconi F, Miglio A. Detection of Serum Allergen-Specific IgE in Atopic Dogs Tested in Northern Italy: Preliminary Study. Animals (Basel) 2021 Feb 1;11(2).
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