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Home / Equine Research Bank / Animals (Basel) / Association between Eosinophil Count and Cortisol Concentrat...
Animals : an open access journal from MDPI2024; 14(1); 164; doi: 10.3390/ani14010164

Association between Eosinophil Count and Cortisol Concentrations in Equids Admitted in the Emergency Unit with Abdominal Pain.

Abstract: Stress leukogram includes eosinopenia as one of its main markers (neutrophilia, eosinopenia, lymphopenia, and mild monocytosis). Cortisol is the main stress biomarker, which is also strongly correlated with the severity of gastrointestinal diseases. This study aimed to determine the relationship between salivary cortisol and the eosinophil cell count (EC) in equids with abdominal pain. To do this, 39 horses with abdominal pain referred to an emergency service were included. All samples were taken on admission, and several parameters and clinical data were included. Equids were classified according to the outcome as survivors and non-survivors. Non-surviving equids presented higher salivary cortisol concentrations (Non-Survivors: 1.580 ± 0.816 µg/dL; Survivors 0.988 ± 0.653 µg/dL; < 0.05) and lower EC (Non-Survivors: 0.0000 × 10/µL (0.000/0.0075); Survivors: 0.0450 × 10/µL (0.010/0.1825); < 0.01). In addition, the relationship between salivary cortisol concentration, EC, and the WBC was determined. Only a strong correlation (negative) was observed between cortisol and EC (r = -0.523, < 0.01). Since cortisol is not an analyte that can be measured routinely in clinical settings such as emergencies, the EC could be a good alternative. While the results are promising, further studies are needed before EC can be used confidently in routine practice to predict survival in cases of abdominal pain.
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Publication Date: 2024-01-04 PubMed ID: 38200895PubMed Central: PMC10778409DOI: 10.3390/ani14010164Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research examines the relationship between the level of cortisol, a stress biomarker, and the eosinophil cell count in horses experiencing abdominal pain. The study specifically finds that higher cortisol levels and lower eosinophil cell counts are observed in horses that do not survive the condition.

Study Purpose and Research Method

  • The main purpose of the study was to establish a correlation between the levels of salivary cortisol and the eosinophil cell count in horses with abdominal pain. This was achieved by analyzing saliva samples from 39 horses admitted to an emergency unit with abdominal pain.
  • The parameters of the samples, as well as the clinical data of each horse, were carefully recorded. Based on the outcomes, the horses were divided into two categories: survivors and non-survivors.

Study Findings

  • The study found a discernible difference in the cortisol concentrations and eosinophil cell counts between the two groups. Specifically, the non-surviving horses had notably higher levels of salivary cortisol and significantly lower eosinophil cell counts compared to the survivors.
  • Furthermore, a strong negative correlation was observed between cortisol levels and eosinophil cell count. In other words, as cortisol levels increased, eosinophil cell counts typically decreased.

Implications of the Research

  • The researched concluded that eosinophil cell count could potentially serve as a suitable alternative to measure stress levels in emergency situations, given the finding that cortisol, which is not often measured in such conditions, exhibited a pronounced correlation with eosinophil cell count.
  • Yet, the researchers advised caution and called for further studies before eosinophil cell count could be confidently implemented as a routine practice to predict survival in cases of abdominal pain amongst horses.

Cite This Article

APA
Villalba-Orero M, Contreras-Aguilar MD, Cerón JJ, Fuentes-Romero B, Valero-González M, Martín-Cuervo M. (2024). Association between Eosinophil Count and Cortisol Concentrations in Equids Admitted in the Emergency Unit with Abdominal Pain. Animals (Basel), 14(1), 164. https://doi.org/10.3390/ani14010164

Publication

Animals : an open access journal from MDPI
ISSN: 2076-2615
NlmUniqueID: 101635614
Country: Switzerland
Language: English
Volume: 14
Issue: 1
PII: 164

Researcher Affiliations

Villalba-Orero, María
  • Hospital Clínico Veterinario Complutense, Departamento de Medicina y Cirugía Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, 28040 Madrid, Spain.
Contreras-Aguilar, María Dolores
  • Interdisciplinary Laboratory of Clinical Analysis of the University of Murcia (Interlab-UMU), Department of Animal Medicine and Surgery, Veterinary School, Regional Campus of International Excellence Mare Nostrum, Campus de Espinardo, University of Murcia, 30100 Murcia, Spain.
Cerón, Jose Joaquín
  • Interdisciplinary Laboratory of Clinical Analysis of the University of Murcia (Interlab-UMU), Department of Animal Medicine and Surgery, Veterinary School, Regional Campus of International Excellence Mare Nostrum, Campus de Espinardo, University of Murcia, 30100 Murcia, Spain.
Fuentes-Romero, Beatriz
  • Veterinary Teaching Hospital, University of Extremadura, Avda de la Universidad s/n, 10005 Cáceres, Spain.
Valero-González, Marta
  • Veterinary Teaching Hospital, University of Extremadura, Avda de la Universidad s/n, 10005 Cáceres, Spain.
Martín-Cuervo, María
  • Grupo MECIAN, Departamento de Medicina Animal, Facultad de Veterinaria, Campus de Cáceres, Universidad de Extremadura, 10004 Cáceres, Spain.

Grant Funding

  • 19894/GERM/15 / Fundaciu00f3n Su00e9neca - Agencia de Ciencia y Tecnologu00eda de la Regiu00f3n de Murcia

Conflict of Interest Statement

The authors declare no conflict of interest.

References

This article includes 52 references
  1. Gehlen H, Faust M.D, Grzeskowiak R.M, Trachsel D.S. Association between Disease Severity, Heart Rate Variability (HRV) and Serum Cortisol Concentrations in Horses with Acute Abdominal Pain. Animals 2020;10:1563.
    doi: 10.3390/ani10091563pmc: PMC7552187pubmed: 32887514google scholar: lookup
  2. Stewart A.J, Hackett E, Bertin F.R, Towns T.J. Cortisol and Adrenocorticotropic Hormone Concentrations in Horses with Systemic Inflammatory Response Syndrome. J. Vet. Intern. Med. 2019;33:2257–2266.
    doi: 10.1111/jvim.15620pmc: PMC6766528pubmed: 31512777google scholar: lookup
  3. Martín-Cuervo M, Gracia-Calvo L.A, Macías-García B, Ezquerra L.J, Barrera R. Evaluation of Eosinopenia as a SIRS Biomarker in Critically Ill Horses. Animals 2022;12:3547.
    doi: 10.3390/ani12243547pmc: PMC9774166pubmed: 36552467google scholar: lookup
  4. Hinchcliff K.W, Rush B.R, Farris J.W. Evaluation of Plasma Catecholamine and Serum Cortisol Concentrations in Horses with Colic. J. Am. Vet. Med. Assoc. 2005;227:276–280.
    doi: 10.2460/javma.2005.227.276pubmed: 16047666google scholar: lookup
  5. Mott R.O, Hawthorne S.J, McBride S.D. Blink Rate as a Measure of Stress and Attention in the Domestic Horse (Equus Caballus). Sci. Rep. 2020;10:21409.
    doi: 10.1038/s41598-020-78386-zpmc: PMC7722727pubmed: 33293559google scholar: lookup
  6. Bohák Z, Szabó F, Beckers J.F, Melo de Sousa N, Kutasi O, Nagy K, Szenci O. Monitoring the Circadian Rhythm of Serum and Salivary Cortisol Concentrations in the Horse. Domest. Anim. Endocrinol. 2013;45:38–42.
    doi: 10.1016/j.domaniend.2013.04.001pubmed: 23688596google scholar: lookup
  7. Schmidt A, Hödl S, Möstl E, Aurich J, Müller J, Aurich C. Cortisol Release, Heart Rate, and Heart Rate Variability in Transport-Naive Horses during Repeated Road Transport. Domest. Anim. Endocrinol. 2010;39:205–213.
    doi: 10.1016/j.domaniend.2010.06.002pubmed: 20688463google scholar: lookup
  8. Kedzierski W, Cywińska A, Strzelec K, Kowalik S. Changes in Salivary and Plasma Cortisol Levels in Purebred Arabian Horses during Race Training Session. Anim. Sci. J. 2014;85:313–317.
    doi: 10.1111/asj.12146pubmed: 24261657google scholar: lookup
  9. Peeters M, Sulon J, Beckers J.F, Ledoux D, Vandenheede M. Comparison between Blood Serum and Salivary Cortisol Concentrations in Horses Using an Adrenocorticotropic Hormone Challenge. Equine Vet. J. 2011;43:487–493.
    doi: 10.1111/j.2042-3306.2010.00294.xpubmed: 21496072google scholar: lookup
  10. Munk R, Jensen R.B, Palme R, Munksgaard L, Christensen J.W. An Exploratory Study of Competition Scores and Salivary Cortisol Concentrations in Warmblood Horses. Domest. Anim. Endocrinol. 2017;61:108–116.
    doi: 10.1016/j.domaniend.2017.06.007pubmed: 28800426google scholar: lookup
  11. Contreras-Aguilar M.D, Escribano D, Martín-Cuervo M, Tecles F, Cerón J.J. Salivary Alpha-Amylase Activity and Cortisol in Horses with Acute Abdominal Disease: A Pilot Study. BMC Vet. Res. 2018;14:156.
    doi: 10.1186/s12917-018-1482-4pmc: PMC5946548pubmed: 29747642google scholar: lookup
  12. Bass D.A, Gonwa T.A, Szejda P, Cousart M.S, DeChatelet L.R, McCall C.E. Eosinopenia of Acute Infection: Production of eosinopenia by chemotactic factors of acute inflammation. J. Clin. Investig. 1980;65:1265–1271.
    doi: 10.1172/JCI109789pmc: PMC371463pubmed: 7410543google scholar: lookup
  13. Terradas R, Grau S, Blanch J, Riu M, Saballs P, Castells X, Horcajada J.P, Knobel H. Eosinophil Count and Neutrophil-Lymphocyte Count Ratio as Prognostic Markers in Patients with Bacteremia: A Retrospective Cohort Study. PLoS ONE 2012;7:e42860.
    doi: 10.1371/journal.pone.0042860pmc: PMC3415420pubmed: 22912753google scholar: lookup
  14. Abidi K, Khoudri I, Belayachi J, Madani N, Zekraoui A, Zeggwagh A, Abouqal R. Eosinopenia Is a Reliable Marker of Sepsis on Admission to Medical Intensive Care Units. Crit. Care 2008;12:R59.
    doi: 10.1186/cc6883pmc: PMC2447615pubmed: 18435836google scholar: lookup
  15. Merino C.A, Martínez F.T, Cardemil F, Rodríguez J.R. Absolute Eosinophils Count as a Marker of Mortality in Patients with Severe Sepsis and Septic Shock in an Intensive Care Unit. J. Crit. Care 2012;27:394–399.
    doi: 10.1016/j.jcrc.2011.10.010pubmed: 22176807google scholar: lookup
  16. Abidi K, Belayachi J, Derras Y, El Khayari M, Dendane T, Madani N, Khoudri I, Zeggwagh A.A, Abouqal R. Eosinopenia, an Early Marker of Increased Mortality in Critically Ill Medical Patients. Intensive Care Med. 2011;37:1136–1142.
    doi: 10.1007/s00134-011-2170-zpubmed: 21369810google scholar: lookup
  17. Sevinç M.M, Kınacı E, Çakar E, Bayrak S, Özakay A, Aren A, Sarı S. Diagnostic Value of Basic Laboratory Parameters for Simple and Perforated Acute Appendicitis: An Analysis of 3392 Cases. Ulus. Travma Acil Cerrahi Derg.-Turk. J. Trauma Emerg. Surg. 2016;22:155–162.
    doi: 10.5505/TJTES.2016.54388pubmed: 27193983google scholar: lookup
  18. Andersen M, Bro-Rasmussen F. Autoradiographic studies of eosinophil kinetics: Effects of cortisol. Cell Tissue Kin. 1969;2:139–146.
    doi: 10.1111/j.1365-2184.1969.tb01000.xgoogle scholar: lookup
  19. Sheats M.K. A Comparative Review of Equine SIRS, Sepsis, and Neutrophils. Front. Vet. Sci. 2019;6:69.
    doi: 10.3389/fvets.2019.00069pmc: PMC6424004pubmed: 30931316google scholar: lookup
  20. Moore J.N, Vandenplas M.L. Is It the Systemic Inflammatory Response Syndrome or Endotoxemia in Horses with Colic?. Vet. Clin. N. Am. Equine Pract. 2014;30:337–351.
    doi: 10.1016/j.cveq.2014.04.003pubmed: 25016495google scholar: lookup
  21. Contreras-Aguilar M.D, Hevia M.L, Escribano D, Lamy E, Tecles F, Cerón J.J. Effect of Food Contamination and Collection Material in the Measurement of Biomarkers in Saliva of Horses. Res. Vet. Sci. 2020;129:90–95.
    doi: 10.1016/j.rvsc.2020.01.006pubmed: 31954319google scholar: lookup
  22. Frøssing L, Hartvig Lindkaer Jensen T, Østrup Nielsen J, Hvidtfeldt M, Silberbrandt A, Parker D, Porsbjerg C, Backer V. Automated Cell Differential Count in Sputum Is Feasible and Comparable to Manual Cell Count in Identifying Eosinophilia. J. Asthma. 2022;59:552–560.
    doi: 10.1080/02770903.2020.1868498pubmed: 33356683google scholar: lookup
  23. Cadena-Herrera D, Esparza-De Lara J.E, Ramírez-Ibañez N.D, López-Morales C.A, Pérez N.O, Flores-Ortiz L.F, Medina-Rivero E. Validation of Three Viable-Cell Counting Methods: Manual, Semi-Automated, and Automated. Biotechnol. Rep. 2015;7:9–16.
    doi: 10.1016/j.btre.2015.04.004pmc: PMC5466062pubmed: 28626709google scholar: lookup
  24. Escribano D, Fuentes-Rubio M, Cerón J.J. Validation of an Automated Chemiluminescent Immunoassay for Salivary Cortisol Measurements in Pigs. J. Vet. Diagn. Investig. 2012;24:918–923.
    doi: 10.1177/1040638712455171pubmed: 22914821google scholar: lookup
  25. Hagen J, Kojah K, Geiger M. Correlations between the Equine Metacarpophalangeal Joint Angulation and Toe Conformation in Statics. Open Vet. J. 2018;8:96–103.
    doi: 10.4314/ovj.v8i1.15pmc: PMC5918130pubmed: 29721438google scholar: lookup
  26. Lee Y, Yi H.S, Kim H.R, Joung K.H, Kang Y.E, Lee J.H, Kim K.S, Kim H.J, Ku B.J, Shong M. The Eosinophil Count Tends to Be Negatively Associated with Levels of Serum Glucose in Patients with Adrenal Cushing Syndrome. Endocrinol. Metab. 2017;32:353–359.
    doi: 10.3803/EnM.2017.32.3.353pmc: PMC5620032pubmed: 28956365google scholar: lookup
  27. Yang H, Wu K, Zhang H, Owyang Q, Miao Y, Gu F, Hu N, Zou K, Sheng J, Li J. IgA, Albumin, and Eosinopenia as Early Indicators of Cytomegalovirus Infection in Patients with Acute Ulcerative Colitis. BMC Gastroenterol. 2020;20:294.
    doi: 10.1186/s12876-020-01434-5pmc: PMC7487863pubmed: 32891125google scholar: lookup
  28. Kulaylat A.S, Buonomo E.L, Scully K.W, Hollenbeak C.S, Cook H, Petri W.A, Stewart D.B. Development and Validation of a Prediction Model for Mortality and Adverse Outcomes Among Patients With Peripheral Eosinopenia on Admission for Clostridium Difficile Infection. JAMA Surg. 2018;153:1127–1133.
    doi: 10.1001/jamasurg.2018.3174pmc: PMC6414272pubmed: 30208386google scholar: lookup
  29. Holland M, Alkhalil M, Chandromouli S, Janjua A, Babores M. Eosinopenia as a Marker of Mortality and Length of Stay in Patients Admitted with Exacerbations of Chronic Obstructive Pulmonary Disease. Respirology 2010;15:165–167.
    doi: 10.1111/j.1440-1843.2009.01651.xpubmed: 19947999google scholar: lookup
  30. Alkhalil M, Kearney A, Hegarty M, Stewart C, Devlin P, Owens C.G, Spence M.S. Eosinopenia as an Adverse Marker of Clinical Outcomes in Patients Presenting with Acute Myocardial Infarction. Am. J. Med. 2019;132:e827–e834.
    doi: 10.1016/j.amjmed.2019.05.021pubmed: 31152721google scholar: lookup
  31. Behera J.R, Rup A.R, Dash A.K, Sahu S.K, Gaurav A, Gupta A. Clinical and Laboratory Profile of Enteric Fever in Children From a Tertiary Care Centre in Odisha, Eastern India. Cureus 2021;13:e12826.
    doi: 10.7759/cureus.12826pmc: PMC7899128pubmed: 33633872google scholar: lookup
  32. Kim Y.H, Park H.B, Kim M.J, Kim H.S, Lee H.S, Han Y.K, Kim K.W, Sohn M.H, Kim K.E. Prognostic Usefulness of Eosinopenia in the Pediatric Intensive Care Unit. J. Korean Med. Sci. 2013;28:114–119.
    doi: 10.3346/jkms.2013.28.1.114pmc: PMC3546089pubmed: 23341721google scholar: lookup
  33. Garnacho-Montero J, Huici-Moreno M.J, Gutiérrez-Pizarraya A, López I, Márquez-Vácaro J.A, Macher H, Guerrero J.M, Puppo-Moreno A. Prognostic and Diagnostic Value of Eosinopenia, C-Reactive Protein, Procalcitonin, and Circulating Cell-Free DNA in Critically Ill Patients Admitted with Suspicion of Sepsis. Crit. Care 2014;18:R116.
    doi: 10.1186/cc13908pmc: PMC4229882pubmed: 24903083google scholar: lookup
  34. Bouldoires B, Gil H, Soumagne T, Humbert S, Meaux Ruault N, Magy Bertrand N. Proposition d’un Score Prédictif d’infection Bactérienne Selon Le Taux d’éosinophiles: Étude Observationnelle. Rev. Med. Interne. 2018;39:10–16.
    doi: 10.1016/j.revmed.2017.10.425pubmed: 29223347google scholar: lookup
  35. Hogan S.P, Waddell A, Fulkerson P.C. Eosinophils in Infection and Intestinal Immunity. Curr. Opin. Gastroenterol. 2013;29:7–14.
    doi: 10.1097/MOG.0b013e32835ab29apmc: PMC3924957pubmed: 23132211google scholar: lookup
  36. Lipkin W.I. Eosinophil Counts in Bacteremia. Arch. Intern. Med. 1979;139:490–491.
    doi: 10.1001/archinte.1979.03630410094035pubmed: 435009google scholar: lookup
  37. Brosnahan M. Eosinophils of the horse: Part II: Eosinophils in clinical diseases. Equine Vet. Ed. 2020;32:590–602.
    doi: 10.1111/eve.13262google scholar: lookup
  38. Aladio J.M, Costa D, Matsudo M, Pérez de la Hoz A, González D, Brignoli A, Swieszkowski S.P, Pérez de la Hoz R. Cortisol-Mediated Stress Response and Mortality in Acute Coronary Syndrome. Curr. Probl. Cardiol. 2021;46:100623.
    doi: 10.1016/j.cpcardiol.2020.100623pubmed: 32505389google scholar: lookup
  39. Jutla S.K, Yuyun M.F, Quinn P.A, Ng L.L. Plasma Cortisol and Prognosis of Patients with Acute Myocardial Infarction. J. Cardiovasc. Med. 2014;15:33–41.
    doi: 10.2459/JCM.0b013e328364100bpubmed: 24500236google scholar: lookup
  40. Boonen E, Van Den Berghe G. Cortisol Metabolism in Critical Illness: Implications for Clinical Care. Curr. Opin. Endocrinol. Diabetes Obes. 2014;21:185–192.
    doi: 10.1097/MED.0000000000000066pubmed: 24722172google scholar: lookup
  41. Schrepf A, Thaker P.H, Goodheart M.J, Bender D, Slavich G.M, Dahmoush L, Penedo F, DeGeest K, Mendez L, Lubaroff D.M. Diurnal Cortisol and Survival in Epithelial Ovarian Cancer. Psychoneuroendocrinology 2015;53:256–267.
    doi: 10.1016/j.psyneuen.2015.01.010pmc: PMC4440672pubmed: 25647344google scholar: lookup
  42. Yang X, Ren W, Zu H, Dong Q. Evaluate the Serum Cortisol in Patients with Intracerebral Hemorrhage. Clin. Neurol. Neurosurg. 2014;123:127–130.
    doi: 10.1016/j.clineuro.2014.05.019pubmed: 25012024google scholar: lookup
  43. Mair T.S, Sherlock C.E, Boden L.A. Serum Cortisol Concentrations in Horses with Colic. Vet. J. 2014;201:370–377.
    doi: 10.1016/j.tvjl.2014.06.005pubmed: 24986316google scholar: lookup
  44. Harbuz M.S, Lightman S.L. Stress and the Hypothalamo-Pituitary-Adrenal Axis: Acute, Chronic and Immunological Activation. J. Endocrinol. 1992;134:327–339.
    doi: 10.1677/joe.0.1340327pubmed: 1402543google scholar: lookup
  45. Ayala I, Martos N.F, Silvan G, Gutierrez-Panizo C, Clavel J.G, Illera J.C. Cortisol, Adrenocorticotropic Hormone, Serotonin, Adrenaline and Noradrenaline Serum Concentrations in Relation to Disease and Stress in the Horse. Res. Vet. Sci. 2012;93:103–107.
    doi: 10.1016/j.rvsc.2011.05.013pubmed: 21641009google scholar: lookup
  46. Hammer F, Deutschbein T, Marx A, Güder G, Michalski R, Ertl G, Allolio B, Angermann C.E, Störk S, Fassnacht M. High Evening Salivary Cortisol Is an Independent Predictor of Increased Mortality Risk in Patients with Systolic Heart Failure. Int. J. Cardiol. 2016;203:69–73.
    doi: 10.1016/j.ijcard.2015.10.084pubmed: 26492313google scholar: lookup
  47. Elbuken G, Karaca Z, Tanriverdi F, Unluhizarci K, Sungur M, Dogany M, Kelestimur F. Comparison of Total, Salivary and Calculated Free Cortisol Levels in Patients with Severe Sepsis. J. Intensive Care. 2016;4:3.
    doi: 10.1186/s40560-015-0125-0pmc: PMC4706674pubmed: 26753096google scholar: lookup
  48. Tzira D, Prezerakou A, Papadatos I, Vintila A, Bartzeliotou A, Apostolakou F, Papassotiriou I, Papaevangelou V. Salivary Biomarkers May Measure Stress Responses in Critically Ill Children. SAGE Open Med. 2018;6:2050312118802452.
    doi: 10.1177/2050312118802452pmc: PMC6156207pubmed: 30263122google scholar: lookup
  49. Ciancia S, van den Berg S.A.A, van den Akker E.L.T. The Reliability of Salivary Cortisol Compared to Serum Cortisol for Diagnosing Adrenal Insufficiency with the Gold Standard ACTH Stimulation Test in Children. Children 2023;10:1569.
    doi: 10.3390/children10091569pmc: PMC10527706pubmed: 37761530google scholar: lookup
  50. Jung C, Greco S, Nguyen H.H.T, Ho J.T, Lewis J.G, Torpy D.J, Inder W.J. Plasma, Salivary and Urinary Cortisol Levels Following Physiological and Stress Doses of Hydrocortisone in Normal Volunteers. BMC Endocr. Disord. 2014;14:91.
    doi: 10.1186/1472-6823-14-91pmc: PMC4280712pubmed: 25425285google scholar: lookup
  51. Lilliehöök I, Tvedten H.W, Bröjer J, Edner A, Nostell K. Time-Related Changes in Equine Neutrophils after Experimental Endotoxemia: Myeloperoxidase Staining, Size, and Numbers. Vet. Clin. Pathol. 2016;45:66–72.
    doi: 10.1111/vcp.12334pubmed: 26918552google scholar: lookup
  52. Zierath D, Tanzi P, Shibata D, Becker K.J. Cortisol Is More Important than Metanephrines in Driving Changes in Leukocyte Counts after Stroke. J. Stroke Cerebrovasc. Dis. 2018;27:555–562.
    doi: 10.1016/j.jstrokecerebrovasdis.2017.09.048pmc: PMC5811368pubmed: 29097060google scholar: lookup

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