Beyond blood sugar: the potential of NMR-based metabonomics for type 2 human diabetes, and the horse as a possible model.
Abstract: Metabonomic analysis is a powerful tool for identifying and characterizing metabolic disorders, for example type 2 diabetes and the metabolic syndrome. Nuclear magnetic resonance (NMR) spectroscopy is an essential tool for such analysis, with special benefits. The review assesses the current status and potential of NMR-based metabonomics of type 2 diabetes. The horse is proposed as a possible model for studying this condition and disease. Some examples are shown of horse blood analyses by NMR.
Publication Date: 2006-11-28 PubMed ID: 17131108DOI: 10.1007/s00216-006-0979-zGoogle Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The research article focuses on the utility of nuclear magnetic resonance (NMR) spectroscopy based metabonomics for the study and analysis of metabolic disorders like type 2 diabetes, and states that horses might serve as a plausible model for studying this condition.
Understanding metabonomics and NMR spectroscopy
- Metabonomics is a technique used to study metabolic processes at a molecular level. It focuses on the comprehensive measurement of metabolites in biological systems to understand the biochemical changes associated with a disease state, such as type 2 diabetes.
- Nuclear Magnetic Resonance (NMR) spectroscopy is a scientific method that uses the magnetic properties of certain atomic nuclei to study physical, chemical, and biological properties of matter. In the context of metabonomics, it provides key benefits such as being non-invasive, quantitative, and offering a high degree of reproducibility in metabolic profiling.
NMR-based Metabonomics and Type 2 Diabetes
- The paper discusses the current status of NMR-based metabonomics as a powerful tool in the context of type 2 diabetes. This metabolic disorder is characterized by high blood sugar, insulin resistance, and lack of insulin.
- With NMR-based metabonomics, researchers can explore and understand the complex metabolic alterations that occur in type 2 diabetes. This helps in identifying specific metabolic markers for type 2 diabetes, facilitating early diagnosis, more precise prognosis, and monitoring of the disease state.
The Horse as a Model for Studying Type 2 Diabetes
- The study also proposes the potential of using horses as a model to study type 2 diabetes. That’s because horses also develop insulin resistance, a condition that’s similar to type 2 diabetes in humans, making them a fitting model.
- By analyzing horse’s blood using NMR, the researchers give examples of how this technique can be used in real-world scenarios to understand the pathogenesis and progression of the disease. This could eventually lead to the development of novel therapeutic strategies for managing type 2 diabetes in humans.
Cite This Article
APA
Hodavance MS, Ralston SL, Pelczer I.
(2006).
Beyond blood sugar: the potential of NMR-based metabonomics for type 2 human diabetes, and the horse as a possible model.
Anal Bioanal Chem, 387(2), 533-537.
https://doi.org/10.1007/s00216-006-0979-z Publication
Researcher Affiliations
- Department of Chemistry, Princeton University, Princeton, NJ 08544, USA.
MeSH Terms
- Animals
- Blood Glucose
- Diabetes Mellitus, Type 2 / metabolism
- Glucose / metabolism
- Horses
- Humans
- Insulin / blood
- Lipoproteins / blood
- Magnetic Resonance Spectroscopy / methods
- Metabolic Networks and Pathways
- Metabolic Syndrome / metabolism
- Models, Animal
- Plasma / chemistry
Citations
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