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Home / Equine Research Bank / Front Microbiol / Beyond Gut Instinct: Metabolic Short-Chain Fatty Acids Moder...
Frontiers in microbiology2019; 10; 723; doi: 10.3389/fmicb.2019.00723

Beyond Gut Instinct: Metabolic Short-Chain Fatty Acids Moderate the Pathogenesis of Alphaherpesviruses.

Abstract: Short-chain fatty acids (SCFA), such as sodium butyrate (SB), sodium propionate (SPr), and sodium acetate (SAc), are metabolic end-products of the fermentation of dietary fibers. They are linked with multiple beneficial effects on the general mammalian health, based on the sophisticated interplay with the host immune response. Equine herpesvirus 1 (EHV1) is a major pathogen, which primarily replicates in the respiratory epithelium, and disseminates through the body via a cell-associated viremia in leukocytes, even in the presence of neutralizing antibodies. Infected monocytic CD172a cells and T-lymphocytes transmit EHV1 to the endothelium of the endometrium or central nervous system (CNS), causing reproductive or neurological disorders. Here, we questioned whether SCFA have a potential role in shaping the pathogenesis of EHV1 during the primary replication in the URT, during the cell-associated viremia, or at the level of the endothelium of the pregnant uterus and/or CNS. First, we demonstrated the expression of SCFA receptors, FFA2 and FFA3, within the epithelium of the equine respiratory tract, at the cell surface of immune cells, and equine endothelium. Subsequently, EHV1 replication was evaluated in the URT, in the presence or absence of SB, SPr, or SAc. In general, we demonstrated that SCFA do not affect the number of viral plaques or virus titer upon primary viral replication. Only SB and SPr were able to reduce the plaque latitudes. Similarly, pretreatment of monocytic CD172a cells and T-lymphocytes with different concentrations of SCFA did not alter the number of infected cells. When endothelial cells were treated with SB, SPr, or SAc, prior to the co-cultivation with EHV1-inoculated mononuclear cells, we observed a reduced number of adherent immune cells to the target endothelium. This was associated with a downregulation of endothelial adhesion molecules ICAM-1 and VCAM-1 in the presence of SCFA, which ultimately lead to a significant reduction of the EHV1 endothelial plaques. These results indicate that physiological concentrations of SCFA may affect the pathogenesis of EHV1, mainly at the target endothelium, in favor of the fitness of the horse. Our findings may have significant implications to develop innovative therapies, to prevent the devastating clinical outcome of EHV1 infections.
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Publication Date: 2019-04-05 PubMed ID: 31024501PubMed Central: PMC6460668DOI: 10.3389/fmicb.2019.00723Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research focuses on the role of short-chain fatty acids (SCFAs) in influencing the pathogenesis of Equine Herpesvirus 1 (EHV1), a major disease agent in horses. The study demonstrates that SCFAs do not affect primary viral replication, but they can reduce the adhesion of immune cells to the endothelium, thereby reducing the spread of the virus.

Experiment Setup and Findings

  • The study primarily dealt with three types of SCFAs – sodium butyrate (SB), sodium propionate (SPr), and sodium acetate (SAc). These acids are produced by the fermentation of dietary fibers and have a significant impact on general mammalian health primarily due to their interaction with the immune response.
  • The research concentrated on the role of these SCFAs on EHV1, a virus that initially replicates in the respiratory epithelium of horses and spreads through the body by associating with leukocytes. The virus can cause reproductive or neurological disorders in horses when transmitted to the endometrium or central nervous system (CNS) by infected monocytic CD172a cells and T-lymphocytes.
  • The study confirmed the presence of SCFA receptors, FFA2 and FFA3, within the epithelial cells of the equine respiratory tract, immune cells, and equine endothelium. The replication of EHV1 in these cells was then evaluated with or without the presence of the SCFAs. The results showed that the SCFAs did not affect the viral plaques or virus titer during primary viral replication, though SB and SPr were observed to reduce plaque sizes.
  • When monocytic CD172a cells and T-lymphocytes were pretreated with SCFAs, the number of infected cells remained unaltered. However, when endothelial cells were treated with the SCFAs prior to exposure to EHV1-inoculated mononuclear cells, a reduction in the number of immune cells adhering to the target endothelium was observed. This was linked to a reduction in endothelial adhesion molecules ICAM-1 and VCAM-1 in the presence of SCFAs, resulting in a significant reduction of EHV1 endothelial plaques.

Implications and Conclusions

  • These findings suggest that SCFAs, at physiological concentrations, could play a role in altering the pathogenesis of EHV1, mainly at the level of the target endothelium. This would benefit the horse’s health by impeding the spread of the virus within the body
  • The research has implications for potential therapeutic development. Utilizing SCFAs could pave the way for innovative therapies to prevent the severe outcomes of EHV1 infections in horses.

Cite This Article

APA
Poelaert KCK, Van Cleemput J, Laval K, Descamps S, Favoreel HW, Nauwynck HJ. (2019). Beyond Gut Instinct: Metabolic Short-Chain Fatty Acids Moderate the Pathogenesis of Alphaherpesviruses. Front Microbiol, 10, 723. https://doi.org/10.3389/fmicb.2019.00723

Publication

Frontiers in microbiology
ISSN: 1664-302X
NlmUniqueID: 101548977
Country: Switzerland
Language: English
Volume: 10
Pages: 723
PII: 723

Researcher Affiliations

Poelaert, Katrien C K
  • Laboratory of Virology, Department of Virology, Immunology and Parasitology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Van Cleemput, Jolien
  • Laboratory of Virology, Department of Virology, Immunology and Parasitology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
  • 301 Schultz Laboratory, Department of Molecular Biology, Princeton University, Princeton, NJ, United States.
Laval, Kathlyn
  • 301 Schultz Laboratory, Department of Molecular Biology, Princeton University, Princeton, NJ, United States.
Descamps, Sarah
  • Laboratory of Virology, Department of Virology, Immunology and Parasitology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Favoreel, Herman W
  • Laboratory of Virology, Department of Virology, Immunology and Parasitology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Nauwynck, Hans J
  • Laboratory of Virology, Department of Virology, Immunology and Parasitology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.

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Citations

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