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Borna disease: current knowledge and virus detection in France.
Abstract: For over two centuries, Borna disease (BD) has been described as a sporadically occurring infectious meningoencephalomyelitis affecting horses and sheep in Central Europe. Over the last decade, the BD epidemiology has been discussed. Firstly, its geographical distribution seems larger than what was previously thought. Secondly, the disease can affect a large number of warm-blooded animal species, including humans. The aetiological agent is the Boma disease virus (BDV), an enveloped, nonsegmented negative-stranded RNA virus classified in the new virus family Bornaviridae (Mononegavirales order). It can induce severe clinical signs of encephalitis with striking behavioural disturbances and may cause death. BDV genome has recently been detected in France in the blood and brain of several animal species (horses, bovines, foxes).
Publication Date: 2002-04-12 PubMed ID: 11944803DOI: 10.1051/vetres:2002002Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
- Review
Summary
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This research paper explores the current knowledge of Borna disease (BD), including its wider geographical distribution and broader range of warm-blooded animal hosts than previously thought. It also discusses the detection of the BD virus genome in several animal species in France.
Understanding Borna Disease
The research paper focuses on understanding Borna disease, a form of infectious meningoencephalomyelitis that is known to affect animals such as horses and sheep. Borna disease has been studied for over two centuries, predominantly in Central Europe. The disease is characterized by severe clinical signs of encephalitis and disturbing behavioral changes and often leads to the death of the affected species.
- The disease is caused by the Borna disease virus (BDV), a negative-stranded RNA virus that belongs to the Bornaviridae family and the Mononegavirales order.
- This virus is enveloped and nonsegmented, contributing to its unique structural and functional characteristics.
Shifting Epidemiology of Borna Disease
The article also discusses the changing understanding of Borna disease’s epidemiology or the occurrence, distribution, and control of this disease.
- Previously, it was thought that Borna disease predominantly affected Central Europe, but recent studies suggest that its geographical reach is broader than previously estimated.
- The number of warm-blooded animal species affected by this disease is also larger than initially thought, including humans in its range.
Detection of Borna Disease Virus in France
One of the new findings presented in this article is the detection of the Borna disease virus genome in the blood and brain of various animal species in France.
- These species include horses, bovines, and foxes, indicating a broad host range for the disease.
- This recent detection in France expands our previous understanding of the geographical distribution of the Borna Disease Virus.
Cite This Article
APA
Dauphin G, Legay V, Pitel PH, Zientara S.
(2002).
Borna disease: current knowledge and virus detection in France.
Vet Res, 33(2), 127-138.
https://doi.org/10.1051/vetres:2002002 Publication
Researcher Affiliations
- AFSSA Alfort, Maisons-Alfort, France.
MeSH Terms
- Animals
- Borna Disease / diagnosis
- Borna Disease / epidemiology
- Borna Disease / transmission
- Borna Disease / virology
- Borna disease virus / classification
- Borna disease virus / genetics
- Borna disease virus / isolation & purification
- Cattle
- Diagnosis, Differential
- Foxes
- France / epidemiology
- Horses
- Humans
- RNA, Viral / analysis
- Reverse Transcriptase Polymerase Chain Reaction / veterinary
- Sheep
References
This article includes 68 references
Citations
This article has been cited 5 times.- Zhang J, Yang Y, Wang B, Qiu W, Zhang H, Qiu Y, Yuan J, Dong R, Zha Y. Developing a universal multi-epitope protein vaccine candidate for enhanced borna virus pandemic preparedness. Front Immunol 2024;15:1427677.
- Hierweger MM, Werder S, Seuberlich T. Parainfluenza Virus 5 Infection in Neurological Disease and Encephalitis of Cattle. Int J Mol Sci 2020 Jan 13;21(2).
- Barba M, Fairbanks EL, Daly JM. Equine viral encephalitis: prevalence, impact, and management strategies. Vet Med (Auckl) 2019;10:99-110.
- Gunn-Moore D. Infectious diseases of the central nervous system. Vet Clin North Am Small Anim Pract 2005 Jan;35(1):103-28, vi.
- Burnouf T, Griffiths E, Padilla A, Seddik S, Stephano MA, Gutiérrez JM. Assessment of the viral safety of antivenoms fractionated from equine plasma. Biologicals 2004 Sep;32(3):115-28.
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