Bovine reaginic antibody III. Cross-reaction of antihuman IgE and antibovine reaginic immunoglobulin antisera with sera from several species of mammals.
Abstract: Using antisera specific for the heavy chain of human IgE and bovine reaginic immunoglobulin, the degree of cross-reaction amongst sera from pig, rat, rabbit, guinea pig, goat, cow, horse, dog, cat and human was tested. Antihuman IgE antiserum gave strong reactions with pig, rabbit, cow, goat and human sera (100% to 15.1%) and weak reactions with rat, guinea pig, horse, dog and cat sera (10.1% to 3.22%). Antibovine reagin antiserum produced a considerable amount of cross-reaction with sera from pig, rat, rabbit, goat, horse and human (43.6% to 20.1%) with limited reactions with guinea pig, dog and cat sera (13.9% to 9.3%).
Publication Date: 1977-07-01 PubMed ID: 907910PubMed Central: PMC1277601
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- Comparative Study
- Journal Article
Summary
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The research article explores the cross-reaction amongst various mammal sera when tested with antihuman IgE and antibovine reaginic immunoglobulin antisera, demonstrating varying degrees of reactions.
Mammal Sera and Antihuman IgE Antiserum Cross-Reaction
The study employs a range of antisera specific for the human IgE and bovine reaginic immunoglobulin to examine their cross reaction with sera procured from ten diverse mammal species including pig, rat, rabbit, guinea pig, goat, cow, horse, dog, cat, and human.
- The research revealed strong reactions with antihuman IgE antiserum when combined with the sera of pig, rabbit, cow, goat, and humans. The reactions ranged from 100% to 15.1%.
- The study showed comparatively weaker reactions with the exact antiserum when combined with the sera of rat, guinea pig, horse, dog, and cat. These reactions ranged from 10.1% to 3.22%.
Mammal Sera and Antibovine Reaginic Immunoglobulin Antiserum Cross-Reaction
The same degree of cross-reaction was also tested with antibovine reaginic immunoglobulin antisera.
- There was considerable cross-reaction from the antibovine reagin antiserum with the sera from pig, rat, rabbit, goat, horse and human, which ranged from 43.6% to 20.1%.
- On the other hand, the reactions were limited when the antibodies were combined with the sera derived from guinea pig, dog, and cat. These reactions ranged from 13.9% to 9.3%.
Conclusion
This study plays a fundamental role in unveiling the cross-reactive nature of various mammalian sera when tested with antihuman IgE and antibovine reaginic immunoglobulin antisera. It highlights how the strength of interaction varies among different mammalian species, serving as a stepping stone towards advancing our understanding of interspecies immunological responses, especially as they apply to allergy research and treatment.
Cite This Article
APA
Nielsen KH.
(1977).
Bovine reaginic antibody III. Cross-reaction of antihuman IgE and antibovine reaginic immunoglobulin antisera with sera from several species of mammals.
Can J Comp Med, 41(3), 345-348.
Publication
Researcher Affiliations
MeSH Terms
- Animals
- Antibodies
- Cats / immunology
- Cattle / immunology
- Cross Reactions
- Dogs / immunology
- Goats / immunology
- Guinea Pigs / immunology
- Horses / immunology
- Humans
- Immune Sera
- Immunoglobulin E
- Rats / immunology
- Reagins
- Swine / immunology
References
This article includes 19 references
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Citations
This article has been cited 4 times.- Matthews AG, Imlah P, McPherson EA. A reagin-like antibody in horse serum: 1. Occurrence and some biological properties.. Vet Res Commun 1983 Jan;6(1):13-23.
- Matthews AG, Imlah P, McPherson EA. A reagin-like antibody in horse serum. II. Anti-human IgE induced reversed cutaneous anaphylaxis-like responses in horse skin.. Vet Res Commun 1983 Mar;6(2):111-22.
- Lin DS. Feline immune system.. Comp Immunol Microbiol Infect Dis 1992 Jan;15(1):1-11.
- Nielsen K, Sheppard J, Holmes W, Tizard I. Experimental bovine trypanosomiasis. Changes in serum immunoglobulins, complement and complement components in infected animals.. Immunology 1978 Nov;35(5):817-26.
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