Changes of blood biochemical values in ponies recovering from hyperlipemia in Japan.
Abstract: Hyperlipemia in horses is a disorder of lipid metabolism peculiar to ponies. This study reports changes of blood biochemical values from the acute to the postconvalescent phases in 3 Shetland ponies with hyperlipemia in Japan. Diseased ponies (all 7 to 9 years old, in late pregnancy, and obese) were fed in the same farm. The periods of their hospitalizations ranged from 30 to 45 days. Twelve well-conditioned ponies (3 to 13 years old) around parturition were used to establish baseline values for blood test results. Main clinical findings in the affected ponies were depression, dysphagia, anorexia, ventral edema and milky-appearing plasma. Hypertriglyceridemia (40- to 70-fold rise of controls) was found in the acute phase of the disease in the affected ponies, and was derived from increased very-low density lipoproteins. Aspartate transaminase and gamma-glutamyl transpeptidase activities, blood urea nitrogen, and creatinin concentrations were increased in acute ponies compared to controls, suggesting impairment of liver and kidney functions. However, these values gradually recovered until the end of postconvalescent phase. Hyperinsulinemia was observed in the acute phase of the hyperlipemia of all affected ponies. And an exaggerated insulin response to intravenous glucose was observed in the 2 ponies given intravenous glucose tolerance tests. These findings suggest decreased insulin sensitivity in hyperlipemic ponies.
Publication Date: 2006-05-09 PubMed ID: 16679726DOI: 10.1292/jvms.68.353Google Scholar: Lookup
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- Journal Article
Summary
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The research article looks into the changes in blood biochemical values in Shetland ponies suffering from hyperlipemia in Japan, with a particular focus on differences during the acute phase and postconvalescent recovery period.
Study Overview
- Three Shetland ponies, all between 7 to 9 years old, in late pregnancy, and obese were studied. They were all fed in the same farm, and their hospitalization periods varied between 30 to 45 days.
- The research studies changes in their blood biochemical values from the acute phase of the disease to the postconvalescent phase.
- Twelve well-conditioned ponies were used as controls to establish the baseline values for blood test results.
Key Findings
- During the acute phase, ponies demonstrated depression, anorexia, dysphagia, ventral edema, and milky-appearing plasma.
- These ponies also exhibited hypertriglyceridemia in the acute phase, which was due to increased very-low density lipoproteins.
- It was observed that the levels of aspartate transaminase, blood urea nitrogen, and creatinine, alongside the activities of gamma-glutamyl transpeptidase, were higher in the diseased ponies in comparison to the controls. These heightened values indicate possible impairment of liver and kidney functions.
- However, these values gradually returned to normal during the postconvalescent phase.
Hyperinsulinemia and Insulin Resistance
- During the acute phase of hyperlipemia, ponies demonstrated hyperinsulinemia – a condition characterized by excessive levels of insulin in the blood.
- Intravenous glucose tolerance tests were performed on two of the ponies, which showed an exaggerated insulin response. This suggests decreased insulin sensitivity in hyperlipemic ponies, meaning these ponies may be insulin-resistant.
Implication
- These findings on changes in blood biochemical values during hyperlipemia and subsequent recovery can contribute significantly to our understanding of the disease and help in formulating better management and treatment protocols for affected ponies.
Cite This Article
APA
Oikawa S, McGuirk S, Nishibe K, Higuchi T, Kurosawa T, Watanuki M, Satoh H.
(2006).
Changes of blood biochemical values in ponies recovering from hyperlipemia in Japan.
J Vet Med Sci, 68(4), 353-359.
https://doi.org/10.1292/jvms.68.353 Publication
Researcher Affiliations
- Department of Veterinary Internal Medicine, School of Veterinary Medicine, Rakuno Gakuen University, Japan.
MeSH Terms
- Animals
- Blood Glucose
- Female
- Horse Diseases / blood
- Horses
- Hyperlipidemias / blood
- Hyperlipidemias / veterinary
- Insulin / blood
- Japan
- Kidney / metabolism
- Liver / metabolism
- Pregnancy
- Time Factors
Citations
This article has been cited 2 times.- Satué K, Miguel-Pastor L, Chicharro D, Gardón JC. Hepatic Enzyme Profile in Horses. Animals (Basel) 2022 Mar 29;12(7).
- Witkowska-Piłaszewicz O, Cywińska A, Michlik-Połczyńska K, Czopowicz M, Strzelec K, Biazik A, Parzeniecka-Jaworska M, Crisman M, Witkowski L. Variations in haematological and biochemical parameters in healthy ponies. BMC Vet Res 2021 Jan 19;17(1):38.
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