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Experimental & applied acarology2023; 90(1-2); 155-168; doi: 10.1007/s10493-023-00798-z

Circulating oxidative stress and acute phase protein levels in horses infested with ticks.

Abstract: Ticks have saliva rich in immunoregulatory molecules that interfere with the host's physiology in order to feed. This study aimed to evaluate the concentration of acute phase proteins and circulating oxidative stress in response to infestation by Amblyomma sculptum and Dermacentor nitens in two breed horses, Mangalarga Marchador and Breton Postier, to define resistance or susceptibility to ticks. Among the oxidative stress markers, we observed lower malondialdehyde and nitric oxide in horses with tick infestation, consequently not altering the antioxidant enzymes. Breton Postier with tick infestation showed a reduction in the ferric reducing ability of plasma (FRAP), which may be due to lower feeding of the host due to the stress caused by the infestation or even to sequestration of components induced by the tick during blood feeding. The alpha-1-antitrypsin, an acute phase protein, showed an increase in Mangalarga Marchador with tick infestation; curiously it is related to a protective action against tissue damage, pathogens and parasites. We could assume that Mangalarga Marchador showed a better response to ticks when compared to Breton Postier. However, it is still early to define the resistance or susceptibility to ticks, as we did not observe significant changes in most of the analyzed variables. Further studies are needed to understand the compounds and mechanisms of action of the tick saliva in the acute phase proteins and the possible relationships of oxidative stress in the host and the tick during blood feeding.
© 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
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Publication Date: 2023-06-07 PubMed ID: 37285109PubMed Central: 4107163DOI: 10.1007/s10493-023-00798-zGoogle Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research paper explores the effects of tick infestations on horses, specifically focusing on changes in the concentration of acute phase proteins and circulating oxidative stress markers. The results found differences in these biological markers between Mangalarga Marchador and Breton Postier horses when infested with Amblyomma sculptum and Dermacentor nitens ticks.

Objective of the Study

  • The main objective of the study was to measure the changes in acute phase proteins and circulating oxidative stress markers in two breeds of horses (Mangalarga Marchador and Breton Postier) infested by Amblyomma sculptum and Dermacentor nitens ticks. The goal was to determine whether these biological markers could help identify resistance or susceptibility of these breeds to ticks.

Methodology

  • The researchers observed the horses for changes in acute phase proteins and oxidative stress markers, including malondialdehyde and nitric oxide.
  • They also investigated the ferric reducing ability of plasma (FRAP), which can be impacted by the stress of infestation or by components induced by the tick during blood feeding.

Key Findings

  • The study found a decrease in malondialdehyde and nitric oxide levels in horses with tick infestations. However, this did not appear to significantly affect the antioxidant enzymes in the horses.
  • For Breton Postier horses, the researchers observed a reduction in FRAP when ticks were present. This could potentially indicate lower feeding of the horse due to the infestation’s stress, or sequestration of components by the tick during blood feeding.
  • Alpha-1-antitrypsin, an acute phase protein, was found to increase in Mangalarga Marchador horses with tick infestations. This protein is typically associated with protective action against tissue damage, pathogens, and parasites, suggesting that this breed may have a more effective response to ticks.

Conclusions and Further Study

  • While these observations provide some insights into the biological responses to tick infestations in different horse breeds, the researchers admit that it’s still too early to definitively determine resistance or susceptibility based on their data. Most of the observed variables did not show significant changes.
  • They recommend further research to understand tick saliva compounds, their impact on acute phase proteins, and the interplay between oxidative stress in both the host and the tick during blood feeding.

Cite This Article

APA
Nogueira BCF, Orozco AMO, Argumedo AK, de Oliveira Faustino A, de Oliveira LL, da Fonseca LA, Campos AK. (2023). Circulating oxidative stress and acute phase protein levels in horses infested with ticks. Exp Appl Acarol, 90(1-2), 155-168. https://doi.org/10.1007/s10493-023-00798-z

Publication

Experimental & applied acarology
ISSN: 1572-9702
NlmUniqueID: 8507436
Country: Netherlands
Language: English
Volume: 90
Issue: 1-2
Pages: 155-168

Researcher Affiliations

Nogueira, Bárbara Cristina Félix
  • Department of Veterinary Medicine, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil.
Orozco, Andrés Mauricio Ortega
  • Department of Veterinary Medicine, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil.
Argumedo, Ana Karina
  • Department of General Biology, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil.
de Oliveira Faustino, Alessandra
  • Department of General Biology, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil.
de Oliveira, Leandro Licursi
  • Department of General Biology, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil.
da Fonseca, Leandro Abreu
  • Department of Veterinary Medicine, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil.
Campos, Artur Kanadani
  • Department of Veterinary Medicine, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil. artur.kanadani@ufv.br.

MeSH Terms

  • Animals
  • Horses
  • Ticks
  • Tick Infestations / veterinary
  • Acute-Phase Proteins / metabolism
  • Saliva
  • Oxidative Stress
  • Horse Diseases

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