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Home / Equine Research Bank / Ann Surg / Clinical evaluation of equine antithymocyte globulin in reci...
Annals of surgery1974; 180(1); 20-28; doi: 10.1097/00000658-197407000-00004

Clinical evaluation of equine antithymocyte globulin in recipients of renal allografts: Analysis of survival, renal function, rejection, histocompatibility, and complications.

Abstract: Equine antithymocyte globulin combined with azathioprine and prednisone as immunosuppressive therapy in 50 transplant recipients prolonged allograft survival and seemed to modify the severity of rejection episodes. Although nine patients died from a variety of causes, only three kidneys were lost to rejection, one of which was hyperacute. There were no serious untoward hematologic or systemic effects caused by the ATG, and all patients completed the course of therapy. Infection, a serious and frequent complication of transplant patients, was encountered no more often than in other transplant series not using ALG. The data pertaining to the clinical value of ATG, although suggestive in terms of its immunosuppressive effects, is still not conclusive; and a definitive answer to this question awaits further evaluation in a series of cadaveric recipients in a randomized-double-blind study.
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Publication Date: 1974-07-01 PubMed ID: 4599406PubMed Central: PMC1343604DOI: 10.1097/00000658-197407000-00004Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research investigates the use of equine antithymocyte globulin in attendees of kidney transplants and evaluates its effectiveness in terms of survival, kidney function, rejection, compatibility, and complications. The results show a significant advancement in the survival of the transplant and a probable reduction in rejection severity.

Objective of the Research

  • The main purpose of the research was to examine the clinical impact of equine antithymocyte globulin (ATG) when applied together with other immunosuppressive drugs like Azathioprine and Prednisone, to recipients of kidney transplants.

Method and Participants

  • The research was carried out on 50 recipients of kidney transplants who underwent immunosuppressive therapy involving the use of equine ATG along with Azathioprine and Prednisone.

Findings of the Research

  • The use of equine ATG increased the survival period of the kidney transplants, and also seemed to lower the severity of rejection episodes.
  • Despite the fact that nine patients died due to different reasons, only three kidneys were lost to rejection, one of them being hyperacute.
  • No major adverse hematologic or systemic effects were observed from using ATG therapy, and all patients completed their course of therapy.
  • The frequency of infection, which is a common and serious complication for transplant patients, did not increase in comparison to other transplant series not utilizing Antilymphocyte globulin (ALG).

Interpretation and Conclusions

  • The research suggested positive effects of equine ATG in transplant scenarios, especially in relation to its immunosuppressive attributes.
  • However, the study viewed the results as inconclusive, indicating a need for further evaluation to firmly establish the clinical importance of ATG, especially in a series of cadaveric recipients as part of a randomized double-blind study.

Cite This Article

APA
Diethelm AG, Aldrete JS, Shaw JF, Cobbs CG, Hartley MW, Sterling WA, Morgan JM. (1974). Clinical evaluation of equine antithymocyte globulin in recipients of renal allografts: Analysis of survival, renal function, rejection, histocompatibility, and complications. Ann Surg, 180(1), 20-28. https://doi.org/10.1097/00000658-197407000-00004

Publication

Annals of surgery
ISSN: 0003-4932
NlmUniqueID: 0372354
Country: United States
Language: English
Volume: 180
Issue: 1
Pages: 20-28

Researcher Affiliations

Diethelm, A G
    Aldrete, J S
      Shaw, J F
        Cobbs, C G
          Hartley, M W
            Sterling, W A
              Morgan, J M

                MeSH Terms

                • Adolescent
                • Adult
                • Animals
                • Antilymphocyte Serum / adverse effects
                • Antilymphocyte Serum / therapeutic use
                • Azathioprine / therapeutic use
                • Bone Diseases / etiology
                • Child
                • Evaluation Studies as Topic
                • Female
                • Gastrointestinal Diseases / etiology
                • Graft Rejection
                • Histocompatibility
                • Histocompatibility Testing
                • Horses / immunology
                • Humans
                • Infections / etiology
                • Kidney / pathology
                • Kidney / physiology
                • Kidney Transplantation
                • Male
                • Middle Aged
                • Neoplasms / etiology
                • Postoperative Complications
                • Prednisone / therapeutic use
                • T-Lymphocytes / immunology
                • Transplantation, Homologous / mortality

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                Citations

                This article has been cited 6 times.
                1. Fitch Z, Schmitz R, Kwun J, Hering B, Madsen J, Knechtle SJ. Transplant research in nonhuman primates to evaluate clinically relevant immune strategies in organ transplantation.. Transplant Rev (Orlando) 2019 Jul;33(3):115-129.
                  doi: 10.1016/j.trre.2019.03.002pubmed: 31027947google scholar: lookup
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