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Comparative genomic analyses of the Taylorellae.
Abstract: Contagious equine metritis (CEM) is an important venereal disease of horses that is of concern to the thoroughbred industry. Taylorella equigenitalis is a causative agent of CEM but very little is known about it or its close relative Taylorella asinigenitalis. To reveal novel information about Taylorella biology, comparative genomic analyses were undertaken. Whole genome sequencing was performed for the T. equigenitalis type strain, NCTC11184. Draft genome sequences were produced for a second T. equigenitalis strain and for a strain of T. asinigenitalis. These genome sequences were analysed and compared to each other and the recently released genome sequence of T. equigenitalis MCE9. These analyses revealed that T. equigenitalis strains appear to be very similar to each other with relatively little strain-specific DNA content. A number of genes were identified that encode putative toxins and adhesins that are possibly involved in infection. Analysis of T. asinigenitalis revealed that it has a very similar gene repertoire to that of T. equigenitalis but shares surprisingly little DNA sequence identity with it. The generation of genome sequence information greatly increases knowledge of these poorly characterised bacteria and greatly facilitates study of them.
Copyright © 2012 Elsevier B.V. All rights reserved.
Publication Date: 2012-04-06 PubMed ID: 22541164DOI: 10.1016/j.vetmic.2012.03.041Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Comparative Study
- Journal Article
- Animal Health
- Animal Models
- Animal Science
- Comparative Study
- Contagious Equine Metritis
- Disease Diagnosis
- Disease Etiology
- Disease Management
- Disease Prevalence
- Disease Surveillance
- Disease Treatment
- Equine Diseases
- Genetics
- Genomics
- Genotyping
- Infectious Disease
- Molecular biology
- Veterinary Research
- Veterinary Science
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research investigates the genetic makeup of the bacteria Taylorella equigenitalis, a cause of a harmful venereal disease in horses, and its close relative Taylorella asinigenitalis. Whole genome sequencing was performed on multiple strains of these bacteria, with analyses revealing similar gene repertoires among the strains, as well as genes possibly involved in infection.
Comparative Genomic Analyses
- The primary focus of this research was to perform a comparative genomic study on Taylorella equigenitalis and Taylorella asinigenitalis, both of which have had very little prior investigation regarding their genetic structure.
- All strains of T. equigenitalis and T. asinigenitalis were studied. Whole genome sequencing was conducted on the NCTC11184 strain of T. equigenitalis, two other T. equigenitalis strains, and a T. asinigenitalis strain.
Findings on T. equigenitalis Strains
- Analysis of the genomic content of T. equigenitalis strains showed minimal discrepancy among the strains, indicating a significant level of genetic similarity. This suggests that different strains might not drastically differ in their impact or method of causing disease.
- The research also isolated several genes with a potential role in facilitating bacterial infection. This included putative toxins and adhesins, elements which can mediate the adherence of the bacteria to its host.
Comparison Between T. equigenitalis and T. asinigenitalis
- Despite genetic repertoire similarities between T. equigenitalis and T. asinigenitalis, there was surprisingly little DNA sequence identity between the two bacteria. This suggests that while they may perform similar roles or functions, the detailed genetic approaches to these functions might be significantly different between the two.
Implications of the Study
- The genomic sequence data generated from this study aids in the understanding of these bacteria, paving the way for more extensive research on these uncharacterised species.
- This detailed genetic information can be utilized to develop targeted and effective treatments or preventive strategies against the diseases caused by these specific bacteria in horses.
Cite This Article
APA
Hauser H, Richter DC, van Tonder A, Clark L, Preston A.
(2012).
Comparative genomic analyses of the Taylorellae.
Vet Microbiol, 159(1-2), 195-203.
https://doi.org/10.1016/j.vetmic.2012.03.041 Publication
Researcher Affiliations
- Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK.
MeSH Terms
- Adhesins, Bacterial / genetics
- Bacterial Proteins / genetics
- Fimbriae Proteins / genetics
- Genetic Variation
- Genome, Bacterial / genetics
- Sequence Homology, Nucleic Acid
- Taylorella / classification
- Taylorella / genetics
- Taylorella / metabolism
Citations
This article has been cited 7 times.- Hrala M, Andrla P, Bosák J, Fedrová P, Mugutdinov A, Karpíšková R, Nedbalcová K, Raichová J, Faldyna M, Hořín P, Šmajs D. Whole genome sequences of nine Taylorella equigenitalis strains isolated in the Czech Republic between 1982-2021: Molecular dating suggests a common ancestor at the time of Roman Empire. PLoS One 2025;20(1):e0315946.
- Hicks J, Stuber T, Lantz K, Erdman M, Robbe-Austerman S, Huang X. Genomic diversity of Taylorella equigenitalis introduced into the United States from 1978 to 2012. PLoS One 2018;13(3):e0194253.
- May CE, Schulman ML, Howell PG, Lourens CW, Gouws J, Joone C, Monyai MS, le Grange M, Bezuidt OK, Harper CK, Guthrie AJ. Draft Genome Sequence of Taylorella equigenitalis Strain ERC_G2224 Isolated from the Semen of a Lipizzaner Stallion in South Africa. Genome Announc 2015 Oct 15;3(5).
- Hébert L, Touzain F, de Boisséson C, Breuil MF, Duquesne F, Laugier C, Blanchard Y, Petry S. Draft Genome Sequence of Taylorella equigenitalis Strain MCE529, Isolated from a Belgian Warmblood Horse. Genome Announc 2014 Nov 26;2(6).
- Allombert J, Vianney A, Laugier C, Petry S, Hébert L. Survival of taylorellae in the environmental amoeba Acanthamoeba castellanii. BMC Microbiol 2014 Mar 19;14:69.
- Whiteson KL, Hernandez D, Lazarevic V, Gaia N, Farinelli L, François P, Pilo P, Frey J, Schrenzel J. A genomic perspective on a new bacterial genus and species from the Alcaligenaceae family, Basilea psittacipulmonis. BMC Genomics 2014 Mar 1;15:169.
- Hara Y, Hayashi K, Nakajima T, Kagawa S, Tazumi A, Moore JE, Matsuda M. Molecular identification and characterization of clustered regularly interspaced short palindromic repeat (CRISPR) gene cluster in Taylorella equigenitalis. Folia Microbiol (Praha) 2013 Sep;58(5):375-84.
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