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Comparative biochemistry and physiology. Comparative physiology1993; 106(4); 687-694; doi: 10.1016/0300-9629(93)90382-e

Comparative study of the oxyhaemoglobin dissociation curve of four mammals: man, dog, horse and cattle.

Abstract: 1. The entire oxygen dissociation curve (ODC) and the effects of temperature, pH and 2,3-diphosphoglycerate (DPG) on this curve, have been compared in four mammalians: man, dog, horse and cattle. 2. If the oxyphoric capacities are similar between these species (around 1.39 ml O2/gHb), their P50, measured in standard conditions, i.e. at pH 7.4; pCO2 40 mmHg and T 37 degrees C, varies between 23.8 (+/- 0.8) mmHg for the horse, 25.0 (+/- 1.4) mmHg for cattle, 26.6 (+/- 1.2) for man and 28.8 (+/- 2.6) mmHg for the dog. 3. The higher dispersion of the dog's P 50 is due to difference between breeds; in seven breeds investigated, the P 50 ranges from 25.8 (spaniel) to 35.8 (hound). 4. We noted no sex difference in the four species. 5. The DPG level is confirmed to be low in cattle (< 1 mumol/gHb) as compared to man (13.5 +/- 2.1 mumol/gHb), horse (16.9 +/- 1.1 mumol/gHb) and dog (19.4 +/- 2.8 mumol/gHb). 6. The oxygen exchange fraction defined as the difference in vol% between a pO2 of 80 and 35 mmHg is, respectively, 3.6 (+/- 0.6) vol% for cattle, 4.0 (+/- 0.4) vol% for the horse, 5.5 (+/- 0.5) vol% for man and 6.6 (+/- 1.7) vol% for the dog. 7. The position and shape of the ODC, as well as T, DPG and pH effects, indicate that the haemoglobin of man and dog seem better adapted to O2 delivery as compared to the horse and cattle.
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Publication Date: 1993-12-01 PubMed ID: 7906628DOI: 10.1016/0300-9629(93)90382-eGoogle Scholar: Lookup
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  • Comparative Study
  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study compares the oxyhaemoglobin dissociation curve, which plots the relation between the oxygen saturation of haemoglobin and the partial pressure of oxygen, in humans, dogs, horses, and cattle. It examines how factors like temperature, pH, and 2,3-diphosphoglycerate (DPG) levels affect this curve, and suggests that human and canine haemoglobin is better adapted for oxygen delivery than that of horses and cattle.

Oxygen Dissociation Curve across Species

  • The researchers examined the oxygen dissociation curve (ODC) in four mammals: humans, dogs, horses, and cattle.
  • The study found similar oxyphoric capacities (the ability to carry oxygen) across the species. However, the P50 – oxygen pressure when haemoglobin is 50% saturated – varied.
  • Among the animals studied, horses had the lowest P50 at 23.8 mmHg, followed by cattle, humans, and dogs at 25.0, 26.6, and 28.8 mmHg respectively.

Impact of Breed on P50 in Dogs

  • Significant variation was found in the P50 values among different dog breeds.
  • In the seven breeds surveyed, the P50 ranged from 25.8 mmHg in spaniels to 35.8 mmHg in hounds.
  • No differences were found based on sex in any of the four species.

Effects of 2,3-Diphosphoglycerate (DPG) Levels

  • DPG can affect the ODC, making hemoglobin more or less likely to release oxygen to the tissues.
  • Cattle have the lowest DPG levels as compared to humans, dogs, and horses.

Implications for Oxygen Delivery

  • The study concluded that the haemoglobin of humans and dogs seemed better adapted to oxygen delivery compared to that of horses and cattle.
  • The oxygen exchange fraction – the difference in volume percent between a pO2 of 80 and 35 mmHg – was highest in dogs, followed by humans, horses, and cattle.
  • The position and shape of the ODC as well as the effects of temperature, DPG, and pH suggest that human and dog haemoglobin are more efficient in delivering oxygen to tissues.

Cite This Article

APA
Clerbaux T, Gustin P, Detry B, Cao ML, Frans A. (1993). Comparative study of the oxyhaemoglobin dissociation curve of four mammals: man, dog, horse and cattle. Comp Biochem Physiol Comp Physiol, 106(4), 687-694. https://doi.org/10.1016/0300-9629(93)90382-e

Publication

Comparative biochemistry and physiology. Comparative physiology
NlmUniqueID: 9441449
Country: England
Language: English
Volume: 106
Issue: 4
Pages: 687-694

Researcher Affiliations

Clerbaux, T
  • Department of Internal Medicine, Universitaires St Luc, Bruxelles, Belgium.
Gustin, P
    Detry, B
      Cao, M L
        Frans, A

          MeSH Terms

          • 2,3-Diphosphoglycerate
          • Adult
          • Animals
          • Carboxyhemoglobin / metabolism
          • Cattle
          • Diphosphoglyceric Acids / blood
          • Dogs
          • Female
          • Horses
          • Humans
          • Hydrogen-Ion Concentration
          • Male
          • Middle Aged
          • Oxygen / blood
          • Oxyhemoglobins / metabolism
          • Species Specificity
          • Temperature

          Citations

          This article has been cited 14 times.
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