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Veterinary sciences2024; 11(3); doi: 10.3390/vetsci11030124

Comparison of Detomidine or Romifidine in Combination with Morphine for Standing Magnetic Resonance Imaging in Horses.

Abstract: The aim of this study was to determine the most appropriate sedation protocol for a standing magnetic resonance imaging (MRI) examination in horses, comparing continuous rate infusions (CRIs) of detomidine and romifidine combined with a single bolus of morphine. Sixteen horses referred for standing low-field open-magnet MRI were randomly assigned to one of two sedation protocols. The horses were premedicated with 0.03 mg/kg of intramuscular acepromazine, and those animals belonging to Group D received an intravenous (IV) loading dose of detomidine (0.01 mg/kg) 30 min later, while those of Group R received romifidine (0.04 mg/kg). If the horses were inadequately sedated, an additional dose of IV detomidine (0.005 mg/kg) or romifidine (0.02 mg/kg) was administered, according to the animal's group. During the MRI, a single IV bolus of morphine (0.05 mg/kg) was administered, and according to which group it belonged to, the animal started the administration of detomidine (0.01 mg/kg/h) or romifidine (0.02 mg/kg/h). Heart rate (HR), respiratory rate (RR), rectal temperature (RT), depth of sedation, and degree of ataxia were evaluated every 10 min during MRI. Two horses belonging to Group D and four horses from Group R needed additional sedation before entering the MRI unit because they were unsatisfactorily sedated. No side effects were observed following morphine bolus administration. During the MRI procedure, five horses in Group R received an additional IV romifidine bolus (0.01 mg/kg) because the depth of sedation score was 1 and the ataxia score was 0. Any substantial differences were recorded between the two treatments in terms of HR, RR, and RT. In conclusion, at the doses used, a detomidine-morphine combination following a CRI of detomidine appears more suitable than a romifidine-morphine combination following a CRI of romifidine for maintaining an adequate depth of sedation and adequate immobility in horses undergoing standing MRI.
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Publication Date: 2024-03-08 PubMed ID: 38535858PubMed Central: PMC10975525DOI: 10.3390/vetsci11030124Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The study compares the effectiveness of two sedation protocols, detomidine and romifidine, combined with morphine, for horses during standing magnetic resonance imaging (MRI). It found that the detomidine-morphine combination following a continuous rate infusion of detomidine was more effective for maintaining sedation and immobility in horses than the romifidine-morphine protocol.

Research Objective

  • The main aim of the research was to identify the most appropriate sedation protocol for horses undergoing a standing MRI. The protocols compared were continuous rate infusions of detomidine and romifidine, both accompanied by a single morphine bolus.

Research Methodology

  • Sixteen horses undergoing low-field open-magnet MRIs were divided into two groups and assigned different sedation protocols.
  • All the horses were premedicated with acepromazine. The Group D horses then received a dose of detomidine, while Group R horses were given romifidine.
  • If inadequate sedation occurred, the horses were given additional doses of their assigned sedatives.
  • During the MRI, all horses received an IV bolus of morphine and a continuous infusion of their group’s sedative.
  • Horses’ heart rate, respiratory rate, rectal temperature, depth of sedation, and degree of ataxia were evaluated every 10 minutes during the MRI.

Research Findings

  • Some horses from both groups required additional sedatives before entering the MRI because of insufficient sedation.
  • No side effects were observed from the morphine administration.
  • During the procedure, five horses in Group R needed an additional bolus of romifidine because their depth of sedation score was unsatisfactory.
  • No significant differences were found between the two protocols in terms of heart rate, respiratory rate, and rectal temperature.

Conclusion

  • The study concluded that the sedation protocol involving a detomidine-morphine combo and a continuous infusion of detomidine is more effective than the romifidine-morphine combo for maintaining adequate sedation and immobility in horses during standing MRI procedures.

Cite This Article

APA
Vullo C, Gugliandolo E, Biondi V, Biffarella M, Catone G, Tambella AM. (2024). Comparison of Detomidine or Romifidine in Combination with Morphine for Standing Magnetic Resonance Imaging in Horses. Vet Sci, 11(3). https://doi.org/10.3390/vetsci11030124

Publication

Veterinary sciences
ISSN: 2306-7381
NlmUniqueID: 101680127
Country: Switzerland
Language: English
Volume: 11
Issue: 3

Researcher Affiliations

Vullo, Cecilia
  • Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D'Alcontres, 31, 98166 Messina, Italy.
Gugliandolo, Enrico
  • Department of Veterinary Sciences, University of Messina, Polo SS. Annunziata, 98169 Messina, Italy.
Biondi, Vito
  • Department of Veterinary Sciences, University of Messina, Polo SS. Annunziata, 98169 Messina, Italy.
Biffarella, Marco
  • Independent Researcher, Via Anna Salamone, 7, 98073 Mistretta, Italy.
Catone, Giuseppe
  • Department of Veterinary Sciences, University of Messina, Polo SS. Annunziata, 98169 Messina, Italy.
Tambella, Adolfo Maria
  • School of Biosciences and Veterinary Medicine, University of Camerino, 62024 Matelica, Italy.

Conflict of Interest Statement

The authors declare no conflicts of interest.

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