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Home / Equine Research Bank / Vet Sci / Comparison of Hemodynamic Effects of Dobutamine and Ephedrin...
Veterinary sciences2023; 10(4); doi: 10.3390/vetsci10040278

Comparison of Hemodynamic Effects of Dobutamine and Ephedrine Infusions in Isoflurane-Anesthetized Horses.

Abstract: The objective of this study was to compare the hemodynamic effects of dobutamine and ephedrine during the management of anesthesia-related hypotension in healthy horses. Thirteen horses underwent general anesthesia with isoflurane and were randomly divided into two different groups, one of which received a dobutamine constant rate infusion (CRI) (1 µg/kg bwt/min) and the other received an ephedrine CRI (20 µg/kg bwt/min) when hypotension (<60 mmHg) was identified, following up to 15 min after the blood pressure reached 70 mmHg. All horses were equipped with a pulmonary artery catheter and a peripheral artery catheter, and multiparameter monitoring commenced as soon as they were under mechanical ventilation. Hemodynamic parameters were recorded, while tissue perfusion markers (peripheral oxygen saturation, arterial oxygen partial pressure, arterial carbon dioxide partial pressure, arterial pH, arterial plasma bicarbonate concentration, arterial oxygen saturation, mixed venous oxygen saturation, mixed venous oxygen content, arterial oxygen content, arteriovenous oxygen difference, oxygen delivery index, oxygen consumption index, and oxygen extraction ratio), serum lactate concentration, and troponin I concentrations were analyzed before the start of infusions (T0), when the blood pressure reached 70 mmHg (T1), and 15 min after T1 (T2). The time to restore the arterial pressure was similar in both groups (p > 0.05); however, the heart rate was higher in the ephedrine group (p = 0.0098), and sinus bradyarrhythmia occurred in the dobutamine group. Furthermore, both experimental protocols increased cardiac output (p = 0.0012), cardiac index (p = 0.0013), systemic vascular resistance (p = 0.008), systemic vascular resistance index (p < 0.001), and ameliorated perfusion markers. In the dobutamine group, the pulmonary artery wedge pressure (p < 0.001) and systolic index (p = 0.003) were elevated, while the arteriovenous oxygen difference was reduced in the ephedrine group (p = 0.02). Troponin I was used as a myocardial injury indicator, and did not differ between moments or between groups (p > 0.05). We concluded that both drugs were effective and safe to treat anesthetic hypotension under the conditions of this study.
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Publication Date: 2023-04-06 PubMed ID: 37104433PubMed Central: PMC10146723DOI: 10.3390/vetsci10040278Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research study examines and compares the impact of two drugs – dobutamine and ephedrine – on the heart and blood circulation of horses under general anesthesia. The authors found that both drugs were effective in treating anesthesia-related low blood pressure in horses, though they resulted in some different effects on the heart and circulation.

Methodology

  • The research involved 13 horses that were put under general anesthesia with isoflurane. The horses were then divided randomly into two groups to receive either dobutamine or ephedrine.
  • Hemodynamic parameters like heart rate and blood pressure were monitored, and various markers indicating the quality of tissue perfusion, such as oxygen saturation and content, arterial carbon dioxide pressure, and pH were evaluated.
  • These measurements were taken before the drug infusions began (T0), when the blood pressure reached 70 mmHg (T1), and 15 minutes after T1 (T2).
  • In addition, troponin I concentrations were observed as an indicator of possible heart muscle damage.

Results

  • Both the dobutamine and ephedrine groups showed a similar duration for arterial pressure restoration, implying that both drugs were effective in treating hypotension.
  • The heart rate was higher in the ephedrine group, and some horses in the dobutamine group experienced sinus bradyarrhythmia, an irregularly slow heartbeat.
  • Both drugs significantly improved cardiac output and systolic index, demonstrating effectiveness in increasing blood flow.
  • Systemic vascular resistance, which measures the resistance to blood flow, increased in both groups, indicating a rise in blood pressure.
  • In the dobutamine group, there was an increase in pulmonary artery wedge pressure, a measurement of left heart function.
  • The arteriovenous oxygen difference, indicating oxygen utilization in tissues, reduced in the ephedrine group.
  • Troponin I levels did not change significantly, suggesting that neither drug induced heart muscle injury.

Conclusions

  • The study concluded that both dobutamine and ephedrine could be used effectively to manage anesthesia-induced low blood pressure in horses.
  • However, each drug produced different effects on the heart and circulation, which should be taken into account when selecting a drug for this purpose.

Cite This Article

APA
Garcia Filho SG, de Andrade FSRM, Dos Santos RST, Gonçalves LA, Pereira MAA, de Souza AF, Ambrósio AM, Fantoni DT. (2023). Comparison of Hemodynamic Effects of Dobutamine and Ephedrine Infusions in Isoflurane-Anesthetized Horses. Vet Sci, 10(4). https://doi.org/10.3390/vetsci10040278

Publication

Veterinary sciences
ISSN: 2306-7381
NlmUniqueID: 101680127
Country: Switzerland
Language: English
Volume: 10
Issue: 4

Researcher Affiliations

Garcia Filho, Sergio Grandisoli
  • Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, 87 Professor Orlando Marques Paiva Ave., São Paulo 05508-270, SP, Brazil.
de Andrade, Felipe Silveira Rego Monteiro
  • Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, 87 Professor Orlando Marques Paiva Ave., São Paulo 05508-270, SP, Brazil.
Dos Santos, Rosana Souza Thurler
  • Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, 87 Professor Orlando Marques Paiva Ave., São Paulo 05508-270, SP, Brazil.
Gonçalves, Lucas Alaião
  • Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, 87 Professor Orlando Marques Paiva Ave., São Paulo 05508-270, SP, Brazil.
Pereira, Marco Aurélio Amador
  • Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, 87 Professor Orlando Marques Paiva Ave., São Paulo 05508-270, SP, Brazil.
de Souza, Anderson Fernando
  • Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, 87 Professor Orlando Marques Paiva Ave., São Paulo 05508-270, SP, Brazil.
Ambrósio, Aline Magalhães
  • Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, 87 Professor Orlando Marques Paiva Ave., São Paulo 05508-270, SP, Brazil.
Fantoni, Denise Tabacchi
  • Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, 87 Professor Orlando Marques Paiva Ave., São Paulo 05508-270, SP, Brazil.

Grant Funding

  • 001 / Coordenação de Aperfeicoamento de Pessoal de Nível Superior

Conflict of Interest Statement

The authors declare no conflict of interest.

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