Comparison of oxidative stress under different propofol administration protocols in Thoroughbred racehorses by bOS and bAP assessment.
Abstract: It is desirable to reduce surgery-induced oxidative stress (OS) because it can cause immune suppression and delayed wound healing. Propofol is known to have antioxidant potential and to reduce OS in humans, but there have been no studies of this issue in horses. This study was conducted to evaluate OS under three different propofol administration protocols in Thoroughbred racehorses undergoing arthroscopic surgery with sevoflurane anesthesia. Blood oxidative stress (bOS) and blood antioxidant power (bAP) were used as OS biomarkers. Both bOS and bAP significantly decreased after surgery in all groups, but no differences in these reductions were found among them. Different propofol administration protocols with sevoflurane anesthesia did not cause a difference in OS in Thoroughbred racehorses that underwent arthroscopic surgery.
Publication Date: 2018-09-19 PubMed ID: 30250395PubMed Central: PMC6145865DOI: 10.1294/jes.29.75Google Scholar: Lookup
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Summary
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This research investigates the impact of different propofol administration methods on oxidative stress in Thoroughbred racehorses that underwent arthroscopic surgery. Oxidative stress levels and antioxidant power in the blood were used as measures, and the results showed no significant difference among the administration methods.
Understanding the Research
In order the fully grasp the research conducted, let’s break it down into key points:
- The research objective was to explore whether different propofol administration techniques can influence oxidative stress levels in Thoroughbred racehorses undergoing arthroscopic surgery. The anesthesia used during the process was sevoflurane.
- Propofol, a common anesthetic, is recognized for its antioxidant properties and its potential to reduce oxidative stress, a condition that can lead to immune suppression and delayed wound healing, most notably in humans. However, its effects on horses, particularly in the context of different administration protocols, remained unexplored prior to this study.
- To measure oxidative stress, two key markers were used: blood oxidative stress (bOS), which measures the degree of oxidation in the blood, and blood antioxidant power (bAP), which measures the presence and activity of antioxidants in the blood. Both of these markers are significant as they directly indicate the level of antioxidant activity and oxidative stress within the body.
- The result showed a decrease in bOS and bAP after surgery in all groups, indicating that the surgery led to a reduction in the oxidative stress levels of the horses. Yet, it was found that the method of propofol administration did not seem to significantly affect this reduction, suggesting that different administration techniques of propofol may not influence oxidative stress levels in horses undergoing arthroscopic surgery.
Implications of the Research
- This study provides new insights into the role of propofol in horse surgery, adding to the limited current knowledge of propofol’s effects on oxidative stress in these animals.
- The findings may be of practical significance for veterinary practitioners performing arthroscopic surgery on Thoroughbred racehorses. The fact that different propofol administration protocols did not cause a difference in oxidative stress may simplify decision-making around propofol administration protocols during surgery.
- Further research would be beneficial to confirm these findings and to investigate whether the same results apply to other surgical procedures, breeds of horses, or different types of animals.
Cite This Article
APA
Kambayashi Y, Tsuzuki N, Tokushige H, Kusano K.
(2018).
Comparison of oxidative stress under different propofol administration protocols in Thoroughbred racehorses by bOS and bAP assessment.
J Equine Sci, 29(3), 75-78.
https://doi.org/10.1294/jes.29.75 Publication
Researcher Affiliations
- Racehorse Hospital, Miho Training Center, Japan Racing Association, Ibaraki 300-0493, Japan.
- Obihiro University of Agriculture and Veterinary Medicine, Hokkaido 080-8555, Japan.
- Equine Research Institute, Japan Racing Association, Tochigi 329-0412, Japan.
- Racehorse Hospital, Miho Training Center, Japan Racing Association, Ibaraki 300-0493, Japan.
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