Comparison of SN and HI antibody dose response curves in chickens, rabbits, foals and horses following vaccination with equine influenza vaccine.

This research article explores how different animals (chickens, rabbits, foals, and horses) respond to vaccination against equine influenza, analyzing and comparing the antibody response of each species to two different strains of the virus.

Objective of the Research

• The primary goal of the study was to compare Hemagglutination Inhibition (HI) and Serum Neutralization (SN) antibody response curves in chickens, rabbits, foals, and horses after they were vaccinated with equine influenza vaccine.

Comparison of Responses to Different Virus Strains

• The research compared responses to two distinct strains of the equine influenza virus: A/Equi 1/Prague and A/Equi 2/Paris.
• It was found that the HI and SN dose-response curves are parallel for a specific strain, indicating that the antibody response is constant and does not depend on the type of animal species.

Variation in HI and SN Titres

• The study also found that the distribution of HI and SN titres, indicators of the level of an organism’s immune response, varied between the two virus strains.
• This variation is independent of the animal species and may be related to the number of sites necessary for the antigen-antibody response to occur in vitro, or outside of a living organism.

Suggestions for Vaccine Testing

• Basing on these results, the research suggests that the performance testing of equine influenza vaccine could be implemented in chickens.
• This suggestion could potentially simplify the process of vaccine testing, as chickens may offer a more consistent and easily managed model organism than larger animals like horses or foals.