Comparison of the sedative and cardiovascular effects of the combination of acepromazine-clonidine versus acepromazine-xylazine in horses.
Abstract: The aim of this study was to compare the sedative and cardiovascular effects of the combination of acepromazine-clonidine versus acepromazine-xylazine in horses. Four healthy cross-bred horses were included in the study. They were assigned to two treatments. In treatment I (T1), the animals received xylazine hydrochloride (1.00 mg kg) in combination with acepromazine maleate (0.05 mg kg) intravenously (IV). In treatment II (T2), the animals received intra-gastric administration of clonidine (0.002 mg kg) followed by acepromazine (0.05 mg kg; IV) after 60 min. Head height above the ground (HHAG) and echocardiographic indices were evaluated. In T1, recordings were made 5 min before and 5, 15, 30, 60, and 90 min after drug administration. In T2, recordings were made 5 min before clonidine, 55 min after clonidine administration, and then 5, 15, 30, 60, and 90 min after acepromazine injection. Analyses of the data showed there were not significant differences regarding HHAG and echocardiographic indices between two treatments. For sedation of healthy horses, it was concluded that intra-gastric administration of clonidine and IV administration of acepromazine showed similar sedative and cardiovascular effects compared to IV acepromazine-xylazine administration.
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Publication Date: 2024-01-15 PubMed ID: 38464604PubMed Central: PMC10921139DOI: 10.30466/vrf.2023.2004451.3910Google Scholar: Lookup
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Summary
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The research article sought to determine the differences in sedative and cardiovascular effects between two drug combinations (acepromazine-clonidine and acepromazine-xylazine) in horses, concluding that both combinations provided similar results.
Objective and Methodology
- The primary goal of the study was to compare the sedative impact and cardiovascular outcomes of utilizing two distinct combinations of drugs, namely acepromazine-clonidine and acepromazine-xylazine, in horses.
- The study involved four healthy cross-bred horses that were subjected to two treatments.
- The administration of the combinations were done via intravenous injection for one (xylazine hydrochloride with acepromazine maleate) and a combination of intra-gastric administration and intravenous injection for the other (clonidine followed by acepromazine).
Parameter for Evaluation
- To evaluate the effects of the drug combinations, the Head Height Above the Ground (HHAG) and echocardiographic indices were monitored.
- There were specific intervals set for recording these parameters such as 5 minutes before drug administration or after drug administration and also at 15, 30, 60, and 90 minutes post administration.
Findings
- Analysis of the collected data revealed no significant differences between the two treatment groups in terms of HHAG and echocardiographic indices.
- This finding suggests that both combinations of drugs demonstrated comparable sedative and cardiovascular effects.
Conclusion
- The research concluded that for sedating healthy horses, the intra-gastric administration of clonidine followed by an intravenous injection of acepromazine could effectively induce similar sedative and cardiovascular effects as the intravenous administration of acepromazine combined with xylazine’s.
- These findings can potentially influence the choices veterinarians make when looking for a method to sedate horses while maintaining cardiovascular stability.
Cite This Article
APA
Parhizkar P, Mohammadi R, Hashemi-Asl SM, Jalilzadeh-Amin G, Sarrafzadeh-Rezaei F.
(2024).
Comparison of the sedative and cardiovascular effects of the combination of acepromazine-clonidine versus acepromazine-xylazine in horses.
Vet Res Forum, 15(1), 21-26.
https://doi.org/10.30466/vrf.2023.2004451.3910 Publication
Researcher Affiliations
- Department of Surgery and Diagnostic Imaging, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
- Department of Surgery and Diagnostic Imaging, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
- Department of Surgery and Diagnostic Imaging, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
- Department of Internal Medicine and Clinical Pathology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
- Department of Surgery and Diagnostic Imaging, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
Conflict of Interest Statement
There is no conflict of interest to declare.
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