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Complete genome sequence of a polyomavirus isolated from horses.
Abstract: A polyomavirus was isolated from the eyes of horses, and the sequence was determined. A nearly identical VP1 sequence was amplified from the kidney of another animal. We report the complete genome sequence of the first polyomavirus to be isolated from a horse. Analysis shows it to be most closely related overall to human and nonhuman primate polyomaviruses.
Publication Date: 2012-07-31 PubMed ID: 22843861PubMed Central: PMC3421721DOI: 10.1128/JVI.01261-12Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research presents the first-ever complete genome sequence of a polyomavirus derived from horses. Found in the eyes of one horse and nearly identical in the kidney of another, this sequence proved to bear a close relation to human and nonhuman primate polyomaviruses.
Overview of the Research
This groundbreaking study dwells on the discovery and analysis of a polyomavirus found in horses. Revealing the complete genome sequence, it offers valuable insight into the nature of polyomaviruses and their relationship across different species.
- The researchers isolated a polyomavirus – a type of virus associated with some severe diseases – from the eyes of a horse.
- The complete genome sequence of this virus was determined, marking it as the first polyomavirus ever sequenced from a horse.
- A nearly identical sequence of VP1, a gene commonly found in polyomaviruses, was found from the kidney of a different animal, solidifying the findings.
Genetic Analysis and Findings
The study doesn’t limit itself to a mere discovery; it substantiates the findings with an analysis showing similarities to primate polyomaviruses.
- The genetic analysis of this horse polyomavirus showed a remarkable resemblance to polyomaviruses found in human and nonhuman primates. This comparability denotes its evolutionary connection across different species.
- Uncovering the identical VP1 sequence in another animal illustrates that the polyomavirus might not be a horse-specific phenomenon but a potential cross-species infection.
Significance of the Study
The research offers a significant leap forward in the understanding of polyomaviruses, their genome, and cross-species similarities.
- The study opens a new perspective on cross-species viral transmissions, affecting future research on zoonotic diseases (transmitted from animals to humans).
- The complete genome sequence discovery is anticipated to deepen our understanding of polyomaviruses functioning.
- It enables scientists to possibly develop more targeted treatments for polyomavirus-related diseases, benefitting both equine and human health.
Cite This Article
APA
Renshaw RW, Wise AG, Maes RK, Dubovi EJ.
(2012).
Complete genome sequence of a polyomavirus isolated from horses.
J Virol, 86(16), 8903.
https://doi.org/10.1128/JVI.01261-12 Publication
Researcher Affiliations
- Animal Health Diagnostic Center, Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA. rwr3@cornell.edu
MeSH Terms
- Animals
- DNA, Viral / chemistry
- DNA, Viral / genetics
- Eye / virology
- Genome, Viral
- Horse Diseases / virology
- Horses
- Kidney / virology
- Molecular Sequence Data
- Polyomavirus / genetics
- Polyomavirus / isolation & purification
- Polyomavirus Infections / virology
- Sequence Analysis, DNA
References
This article includes 4 references
- Brew BJ, Davies NW, Cinque P, Clifford DB, Nath A. Progressive multifocal leukoencephalopathy and other forms of JC virus disease.. Nat Rev Neurol 2010 Dec;6(12):667-79.
- Cimbaluk D, Pitelka L, Kluskens L, Gattuso P. Update on human polyomavirus BK nephropathy.. Diagn Cytopathol 2009 Oct;37(10):773-9.
- Corrand L, Gelfi J, Albaric O, Etievant M, Pingret JL, Guerin JL. Pathological and epidemiological significance of goose haemorrhagic polyomavirus infection in ducks.. Avian Pathol 2011 Aug;40(4):355-60.
- Halami MY, Dorrestein GM, Couteel P, Heckel G, Müller H, Johne R. Whole-genome characterization of a novel polyomavirus detected in fatally diseased canary birds.. J Gen Virol 2010 Dec;91(Pt 12):3016-22.
Citations
This article has been cited 7 times.- Hu X, Cai D, Liu S, Li Y, Chen L, Luo G, Pu H, He Y, Liu X, Zhao L, Cao H, Yang T, Tian Z. Molecular Characterization of a Novel Budgerigar Fledgling Disease Virus Strain From Budgerigars in China. Front Vet Sci 2021;8:813397.
- Cho M, Kim H, Son HS. Codon usage patterns of LT-Ag genes in polyomaviruses from different host species. Virol J 2019 Nov 14;16(1):137.
- Ehlers B, Anoh AE, Ben Salem N, Broll S, Couacy-Hymann E, Fischer D, Gedvilaite A, Ingenhütt N, Liebmann S, Martin M, Mossoun A, Mugisha L, Muyembe-Tamfum JJ, Pauly M, Pérez de Val B, Preugschas H, Richter D, Schubert G, Szentiks CA, Teichmann T, Walter C, Ulrich RG, Wiersma L, Leendertz FH, Calvignac-Spencer S. Novel Polyomaviruses in Mammals from Multiple Orders and Reassessment of Polyomavirus Evolution and Taxonomy. Viruses 2019 Oct 10;11(10).
- Li Q, Niu K, Sun H, Xia Y, Sun S, Li J, Wang F, Feng Y, Peng X, Zhu L, Fan X, Qin Y, Ding J, Jiang H, Xu G. Complete Genome Sequence of an Avian Polyomavirus Strain First Isolated from a Pigeon in China. Microbiol Resour Announc 2019 Mar;8(10).
- Schürch AC, Schipper D, Bijl MA, Dau J, Beckmen KB, Schapendonk CM, Raj VS, Osterhaus AD, Haagmans BL, Tryland M, Smits SL. Metagenomic survey for viruses in Western Arctic caribou, Alaska, through iterative assembly of taxonomic units. PLoS One 2014;9(8):e105227.
- Stevens H, Bertelsen MF, Sijmons S, Van Ranst M, Maes P. Characterization of a novel polyomavirus isolated from a fibroma on the trunk of an African elephant (Loxodonta africana). PLoS One 2013;8(10):e77884.
- Tao Y, Shi M, Conrardy C, Kuzmin IV, Recuenco S, Agwanda B, Alvarez DA, Ellison JA, Gilbert AT, Moran D, Niezgoda M, Lindblade KA, Holmes EC, Breiman RF, Rupprecht CE, Tong S. Discovery of diverse polyomaviruses in bats and the evolutionary history of the Polyomaviridae. J Gen Virol 2013 Apr;94(Pt 4):738-748.
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