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International journal of molecular sciences2023; 25(1); 205; doi: 10.3390/ijms25010205

Concentrations of Selected Adipocytokines in the Blood Plasma in Proximal Suspensory Desmopathy of Horses, with a Focus on Their Physical Activity-A Pilot Study.

Abstract: Chronic tendon and ligament diseases are commonly encountered in both athletic humans and animals, especially horses. Distal limb diseases, including suspensory ligament (SL) pathology due to anatomical, histological, and biomechanical properties, can be considered a model for tendon and ligament pathologies in humans. The appropriate selection of therapy is often crucial in optimising the healing process. One decisive factor influencing the possibility of returning to pre-disease training levels appears to be the utilisation of physical activity, including controlled movement, during the rehabilitation process. In the pathogenesis of musculoskeletal diseases and rehabilitation, adipocytokines play diverse roles. However, it is unclear what significance they hold in horses and in specific disease entities as well as the consequences of their mutual interactions. Recent studies indicate that in the pathogenesis of diseases with varied aetiologies in humans, their value varies at different stages, resulting in a diverse response to treatment. The results of this study demonstrate lower resistin concentrations in the venous blood plasma of horses with proximal suspensory desmopathy (PSD), while higher levels were observed in regularly trained and paddocked animals. The horses investigated in this study showed higher concentrations of resistin and IL-8, particularly in paddocked horses as well as in the working group of horses. The results suggest that these concentrations, including resistin in blood plasma, may be clinically significant. This attempt to explore the aetiopathogenesis of the processes occurring in the area of the proximal attachment of the suspensory ligament may optimise the procedures for the treatment and rehabilitation of horses.
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Publication Date: 2023-12-22 PubMed ID: 38203376PubMed Central: PMC10778773DOI: 10.3390/ijms25010205Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

Overview

  • This study investigated the levels of certain adipocytokines—signaling proteins produced by fat cells—in the blood plasma of horses with proximal suspensory desmopathy (PSD), a common ligament injury.
  • The research focused on how these adipocytokine concentrations relate to horses’ physical activity and how this understanding may help improve treatment and rehabilitation strategies for tendon and ligament injuries in horses.

Background and Importance

  • Tendon and ligament injuries are frequent in athletic animals and humans, often causing long-term performance issues.
  • Horses’ distal limb conditions, especially suspensory ligament pathologies, serve as useful models for studying similar human injuries due to comparable anatomical and biomechanical factors.
  • Effective treatment and rehabilitation are vital for recovery, with physical activity (like controlled movement) playing a critical role in healing and returning to prior performance levels.
  • Adipocytokines, which are signaling molecules secreted by fat cells, have diverse roles in the development and recovery of musculoskeletal diseases.
  • Despite known roles in humans, the specific significance and dynamics of adipocytokines in horses with ligament diseases like PSD are not well understood.

Purpose of the Study

  • To measure concentrations of selected adipocytokines in the venous blood plasma of horses suffering from PSD.
  • To analyze how these concentrations vary with the horses’ levels of physical activity—specifically comparing regularly trained horses, paddocked horses, and those affected by PSD.
  • To explore potential roles these adipocytokines may play in disease development and rehabilitation outcomes in horses.

Key Findings

  • Horses affected by PSD showed lower concentrations of resistin, an adipocytokine, in their blood plasma compared to healthy or more active horses.
  • Horses that were regularly trained or kept in paddocks had higher levels of resistin and IL-8 (another inflammatory marker) in their plasma.
  • The elevated levels of resistin and IL-8 in active horses suggest these adipocytokines might be linked to physical activity and possibly play a role in both the injury process and healing.
  • Resistin concentration in blood plasma emerged as a potentially clinically valuable marker for understanding PSD status and rehabilitation progress.

Implications for Treatment and Rehabilitation

  • Understanding adipocytokine profiles could help veterinarians tailor treatment plans based on the horse’s adipocytokine levels and activity status.
  • Physical activity influences adipocytokine concentrations, indicating that controlled exercise may modulate inflammatory and healing responses during rehabilitation.
  • This knowledge can enhance optimization of therapies for PSD by balancing rest and activity to influence these molecular markers favorably.
  • The study suggests that monitoring adipocytokines like resistin may provide insights into the disease state and guide recovery strategies more effectively.

Conclusion

  • The study provides the first insights into how adipocytokine concentrations differ in horses with PSD and according to different levels of physical activity.
  • Resistin and IL-8 levels vary significantly, indicating their involvement in the disease’s pathophysiology and response to physical activity.
  • This research lays groundwork for further exploration into the aetiopathogenesis of PSD and for developing refined treatment and rehabilitation protocols based on molecular markers.

Cite This Article

APA
Nowicka B, Torres A, Polkowska I, Jackow-Nowicka J, Przewozny M, Jackow-Malinowska J. (2023). Concentrations of Selected Adipocytokines in the Blood Plasma in Proximal Suspensory Desmopathy of Horses, with a Focus on Their Physical Activity-A Pilot Study. Int J Mol Sci, 25(1), 205. https://doi.org/10.3390/ijms25010205

Publication

International journal of molecular sciences
ISSN: 1422-0067
NlmUniqueID: 101092791
Country: Switzerland
Language: English
Volume: 25
Issue: 1
PII: 205

Researcher Affiliations

Nowicka, Beata
  • Department and Clinic of Animal Surgery, University of Life Sciences in Lublin, Głeboka 30, 20-612 Lublin, Poland.
Torres, Anna
  • Department of Pediatric and Adolescent Gynecology, Medical University of Lublin, Chodzki 4, 20-094 Lublin, Poland.
Polkowska, Izabela
  • Department and Clinic of Animal Surgery, University of Life Sciences in Lublin, Głeboka 30, 20-612 Lublin, Poland.
Jackow-Nowicka, Jagoda
  • Department of General and Interventional Radiology and Neuroradiology, Wroclaw Medical University, ul. Borowska 213, 50-556 Wrocław, Poland.
Przewozny, Maciej
  • Equi Vet Serwis, Wygoda 6, 64-320 Buk, Poland.
Jackow-Malinowska, Joanna
  • St John's Institute of Dermatology, King's College London, London SE1 9RT, UK.

MeSH Terms

  • Humans
  • Animals
  • Horses
  • Adipokines
  • Resistin
  • Pilot Projects
  • Plasma
  • Medicine

Conflict of Interest Statement

The authors declare no conflict of interest.

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