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[Cytogenetic indices for somatic mutagenesis in mammals exposed to chronic low-dose irradiation].

Abstract: We used cytogenetic analysis in the studies of the biological effects of a radiation factor of natural and artificial origin (under conditions ofthe 30-km exclusion zone ofthe Chernobyl experimental landfills in Ukraine, Belarus and Russia). The studies have been performed on various types of mammals: domestic animals--cows, pigs, horses and rodents--root voles, the Af mouse line, and yellow necked field mouse, bank voles. We found significant changes in the level of MN and chromosomal aberrations in the animals that were exposed to the conditions of chronic low-dose radiation for a long time (bothin the habitat and upon exposure in the Chernobyl zone) regardless of the type of animal and nature of contamination.
Publication Date: 2015-05-13 PubMed ID: 25962274
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Summary

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The research article explores the biological impacts of low-dose, long-term radiation on various kinds of mammals such as domestic animals and rodents, by examining changes in their cytogenetic indices. The study was conducted in the 30-km exclusion zone of Chernobyl experimental landfills in Ukraine, Belarus and Russia.

Research Overview

  • The study aimed to investigate the effects of radiation from both natural and artificial sources on different mammals.
  • The research was conducted in the extensive exclusion zone of Chernobyl experimental landfills, areas highly affected by nuclear fallout in Ukraine, Belarus, and Russia.
  • The researchers used cytogenetic analysis, a standard technique for studying genetic effects on cellular level, to examine biological impacts.

Subjects of Study

  • The study was done on a variety of mammals, including kinds of domestic animals such as cows, pigs, and horses, in addition to diverse types of rodents like root voles, bank voles, mice of the Af mouse line, and yellow necked field mice.
  • This wide range of subjects allowed the researchers to get a comprehensive understanding of the effects of radiation across diverse species.

Study Findings

  • The researchers found significant changes in the level of micronuclei (MN) and chromosomal aberrations in the animals exposed to long-term, low-dose radiation.
  • These changes were observed in the animal’s natural environment and after exposure in the Chernobyl zone.
  • The changes occurred regardless of the type of animal tested or the nature of the contamination.

Implication of the Research

  • This research emphasizes on the negative biological impacts of chronic, low-dose radiation exposure on various mammals.
  • The significant changes in cytogenetic indices could indicate potential health risks and genetic damage for animals living in or near radiation-affected zones.
  • Such a comprehensive research could be instrumental in planning strategies for animal conservation in radiation-polluted environments, and also serve as a model to predict potential effects on human populations exposed to similar conditions.

Cite This Article

APA
Kostenko SA, Ermakova OV, Sushko SN, Fyedorova EV, Dzhus PP, Baschlykova LA, Kurylenko YF, Raskosha OV, Savin AO, Shaforost AS. (2015). [Cytogenetic indices for somatic mutagenesis in mammals exposed to chronic low-dose irradiation]. Radiats Biol Radioecol, 55(1), 35-42.

Publication

ISSN: 0869-8031
NlmUniqueID: 9317212
Country: Russia (Federation)
Language: rus
Volume: 55
Issue: 1
Pages: 35-42

Researcher Affiliations

Kostenko, S A
    Ermakova, O V
      Sushko, S N
        Fyedorova, E V
          Dzhus, P P
            Baschlykova, L A
              Kurylenko, Yu F
                Raskosha, O V
                  Savin, A O
                    Shaforost, A S

                      MeSH Terms

                      • Animals
                      • Arvicolinae / genetics
                      • Chernobyl Nuclear Accident
                      • Chromosome Aberrations / radiation effects
                      • Dose-Response Relationship, Radiation
                      • Horses / genetics
                      • Mice
                      • Mutagenesis / genetics
                      • Mutagenesis / radiation effects
                      • Radiation Dosage
                      • Republic of Belarus
                      • Russia
                      • Swine / genetics
                      • Ukraine

                      Citations

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