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Demonstration of specific antibodies in the central nervous system of horses naturally infected with Borna disease virus.
Abstract: From 18 horses with clinical symptoms of an affection of the central nervous system and with histopathologic alterations in the brain, four were demonstrated to have Bornavirus-specific antibodies. The antibodies are monospecific, recognizing identical antigens from infected brains of different animal species as well as from persistently infected tissue culture cells. Discrete immunoglobulin species (oligoclonal IgG) can be demonstrated in concentrated horse cerebrospinal fluid; they carry Bornavirus antibody specificity. Their presence, together with the higher antibody titers in the cerebrospinal fluid as compared to those in the serum, indicate that in these natural Bornavirus infections local antibody production occurred in the central nervous system.
Publication Date: 1977-12-27 PubMed ID: 604728DOI: 10.1007/BF02125505Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Comparative Study
- Journal Article
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
This research considers horses showing signs of a nervous system affection and brain alterations, discovering that four of the 18 horses studied contained specific antibodies for Borna disease virus. The findings imply that these natural Borna virus infections lead to the local production of these antibodies within the central nervous system.
Objectives and Methodology
- The goal of the researchers was to identify the presence of specific antibodies geared toward the Borna disease virus in the central nervous system of horses displaying related symptoms.
- They conducted their study on 18 horses that exhibited signs of a central nervous system disorder and histopathologic changes in the brain.
- These horses were screened for Bornavirus-specific antibodies, which could provide clear indications of a Borna disease virus infection.
Findings
- Out of the 18 horses investigated, four were found to possess Bornavirus-specific antibodies, suggesting they once fought off the Borna disease virus.
- These antibodies displayed monospecificity, indicating they recognized the same antigens from infected brains across different animal species and persistently infected tissue culture cells.
- Discrete immunoglobulin species (oligoclonal IgG) were identified in concentrated horse cerebrospinal fluid, and these demonstrated Bornavirus antibody specificity.
- The higher detection rate of the antibodies in the horses’ cerebrospinal fluid compared to the serum (blood) suggests local antibody production in the central nervous system.
Implications
- The presence of specific antibodies against the Borna virus in the animal’s cerebrospinal fluid implies that the body is mounting a direct immune response within the central nervous system itself to fight the infection.
- This research might offer valuable insight into the pathophysiology of Borna disease and how the immune system naturally combats the virus.
Cite This Article
APA
Ludwig H, Thein P.
(1977).
Demonstration of specific antibodies in the central nervous system of horses naturally infected with Borna disease virus.
Med Microbiol Immunol, 163(4), 215-226.
https://doi.org/10.1007/BF02125505 Publication
Researcher Affiliations
MeSH Terms
- Animals
- Antibodies, Viral / analysis
- Antibodies, Viral / cerebrospinal fluid
- Antibody Specificity
- Borna Disease / immunology
- Borna disease virus / immunology
- Cell Line
- Encephalitis Viruses / immunology
- Horse Diseases / immunology
- Horses
- Immunoglobulin G / analysis
- Immunoglobulin G / cerebrospinal fluid
- Rabbits
References
This article includes 13 references
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- Ludwig H, Koester V, Pauli G, Rott R. The cerebrospinal fluid of rabbits infected with Borna disease virus.. Arch Virol 1977;55(3):209-23.
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Citations
This article has been cited 17 times.- Dürrwald R, Kolodziejek J, Oh DY, Herzog S, Liebermann H, Osterrieder N, Nowotny N. Vaccination against Borna Disease: Overview, Vaccine Virus Characterization and Investigation of Live and Inactivated Vaccines. Viruses 2022 Dec 2;14(12).
- Zhang L, Lei Y, Liu X, Wang X, Liu Z, Li D, Zheng P, Zhang L, Chen S, Xie P. Glutamate and lipid metabolic perturbation in the hippocampi of asymptomatic borna disease virus-infected horses. PLoS One 2014;9(6):e99752.
- Zhang L, Xu MM, Zeng L, Liu S, Liu X, Wang X, Li D, Huang RZ, Zhao LB, Zhan QL, Zhu D, Zhang YY, Xu P, Xie P. Evidence for Borna disease virus infection in neuropsychiatric patients in three western China provinces. Eur J Clin Microbiol Infect Dis 2014 Apr;33(4):621-7.
- Solbrig MV. Animal models of CNS viral disease: examples from borna disease virus models. Interdiscip Perspect Infect Dis 2010;2010:709791.
- Hashimoto Y, Chen HS, Cunningham C, Malik TH, Lai PK. Two major histocompatibility complex class I-restricted epitopes of the Borna disease virus p10 protein identified by cytotoxic T lymphocytes induced by DNA-based immunization. J Virol 2003 May;77(10):6076-81.
- Planz O, Rziha HJ, Stitz L. Genetic relationship of Borna disease virus isolates. Virus Genes 2003 Jan;26(1):25-30.
- Furrer E, Bilzer T, Stitz L, Planz O. High-dose Borna disease virus infection induces a nucleoprotein-specific cytotoxic T-lymphocyte response and prevention of immunopathology. J Virol 2001 Dec;75(23):11700-8.
- Planz O, Pleschka S, Ludwig S. MEK-specific inhibitor U0126 blocks spread of Borna disease virus in cultured cells. J Virol 2001 May;75(10):4871-7.
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- Kliche S, Stitz L, Mangalam H, Shi L, Binz T, Niemann H, Briese T, Lipkin WI. Characterization of the Borna disease virus phosphoprotein, p23. J Virol 1996 Nov;70(11):8133-7.
- Cubitt B, de la Torre JC. Borna disease virus (BDV), a nonsegmented RNA virus, replicates in the nuclei of infected cells where infectious BDV ribonucleoproteins are present. J Virol 1994 Mar;68(3):1371-81.
- Hatalski CG, Kliche S, Stitz L, Lipkin WI. Neutralizing antibodies in Borna disease virus-infected rats. J Virol 1995 Feb;69(2):741-7.
- Gierend M, Ludwig H. Influence of immunosuppressive treatment of Borna Disease in rabbits. Arch Virol 1981;67(3):217-28.
- Gosztonyi G, Ludwig H. Borna disease of horses. An immunohistological and virological study of naturally infected animals. Acta Neuropathol 1984;64(3):213-21.
- Carbone KM, Duchala CS, Griffin JW, Kincaid AL, Narayan O. Pathogenesis of Borna disease in rats: evidence that intra-axonal spread is the major route for virus dissemination and the determinant for disease incubation. J Virol 1987 Nov;61(11):3431-40.
- Ludwig H, Koester V, Pauli G, Rott R. The cerebrospinal fluid of rabbits infected with Borna disease virus. Arch Virol 1977;55(3):209-23.
- Krey H, Ludwig H, Rott R. Spread of infectious virus along the optic nerve into the retina in Borna disease virus-infected rabbits. Arch Virol 1979;61(4):283-8.
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