Determination of cardiac output in neonatal foals by ultrasound velocity dilution and its comparison to the lithium dilution method.
Abstract: To compare cardiac output (CO) measured by use of lithium dilution (LiDCO) and ultrasound velocity dilution (UDCO) in conditions of high, intermediate, and low CO in anesthetized foals. Methods: Original prospective study. Methods: University teaching hospital. Methods: Six foals 1-3 days of age (38-45 kg). Methods: Neonatal foals were anesthetized and instrumented to measure direct blood pressure, heart rate, arterial blood gases, and CO. The CO was measured by use of LiDCO and UDCO techniques. Measurements were obtained from each foal at baseline and during low, intermediate, and high CO states. Measurements were converted to cardiac index (cardiac index=CO/body weight) values for statistical analysis. Agreement between the 2 methods was determined using Bland and Altman analysis and concordance correlation coefficients. Results: LiDCO determinations of CO ranged between 4.0 and 14.0 L/min resulting in cardiac index ranging between 75.5 and 310 mL/kg/min. There was no significant effect of blood pressure variation on bias or relative bias (P=0.62 and 0.93, respectively). The mean bias and relative bias of UDCO (+/-SD) compared with LiDCO were -20.1+/-39.2 mL/kg/min and -7.7+/-23.4%, respectively. Concordance correlation coefficient between LiDCO and UDCO was 0.833. Conclusions: When compared with LiDCO, the UDCO technique has acceptable clinical utility for measuring CO in healthy anesthetized newborn foals.
Publication Date: 2009-10-14 PubMed ID: 19821884DOI: 10.1111/j.1476-4431.2009.00461.xGoogle Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The research article discusses a study comparing cardiac output (CO) measurement techniques, ultrasound velocity dilution (UDCO), and lithium dilution (LiDCO) in neonatal foals. The study found that both methods were effectively applicable, with a high degree of correlation between the two, suggesting UDCO can also be used reliably for measuring CO in neonatal foals under anesthesia.
Objective of the Study
- The primary goal of the study was to compare two techniques used for measuring cardiac output (CO), namely lithium dilution (LiDCO) and ultrasound velocity dilution (UDCO).
- The study aimed to validate the effectiveness of UDCO in different cardiovascular states (high, intermediate, and low CO) of anesthetized neonatal foals, comparing it with the standard LiDCO technique.
Methodology
- The researchers carried out a prospective study at a university teaching hospital, involving six neonatal foals aged between 1 to 3 days and weighing between 38 to 45 kg.
- The foals were anesthetized and scientifically equipped to measure heart rate, arterial blood gases, direct blood pressure, and CO.
- CO measurements were taken at baseline and during low, intermediate, and high CO states, using both LiDCO and UDCO methods.
- The CO measurements were then converted to cardiac index (CO/body weight) values for statistical analysis.
Results
- CO measurements taken by LiDCO ranged from 4.0 to 14.0 L/min, resulting in a cardiac index ranging from 75.5 and 310 mL/kg/min.
- The study found no significant effect of blood pressure variation on the bias or relative bias.
- The mean bias and relative bias of UDCO compared with LiDCO were -20.1±39.2 mL/kg/min and -7.7±23.4%, respectively.
- The concordance correlation coefficient between LiDCO and UDCO was 0.833, indicating a strong agreement between the two methods.
Conclusions
- The study concluded that the UDCO method has acceptable clinical utility for measuring CO in healthy anesthetized newborn foals when compared with the LiDCO.
- The findings suggest that there is a significant correlation between the two methods, validating the UDCO’s applicability in neonatal foals.
Cite This Article
APA
Shih A, Giguère S, Sanchez LC, Valverde A, Bandt C, Jankunas H, Robertson S.
(2009).
Determination of cardiac output in neonatal foals by ultrasound velocity dilution and its comparison to the lithium dilution method.
J Vet Emerg Crit Care (San Antonio), 19(5), 438-443.
https://doi.org/10.1111/j.1476-4431.2009.00461.x Publication
Researcher Affiliations
- Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA. shiha@vetmed.ufl.edu
MeSH Terms
- Animals
- Animals, Newborn
- Cardiac Output / physiology
- Heart Function Tests / methods
- Heart Function Tests / veterinary
- Horses / physiology
- Lithium Chloride / administration & dosage
- Lithium Chloride / blood
- Prospective Studies
- Ultrasonography / methods
- Ultrasonography / veterinary
Citations
This article has been cited 2 times.- Paranjape VV, Garcia-Pereira FL, Menciotti G, Saksena S, Henao-Guerrero N, Ricco-Pereira CH. Evaluation of Electrical Cardiometry for Measuring Cardiac Output and Derived Hemodynamic Variables in Comparison with Lithium Dilution in Anesthetized Dogs. Animals (Basel) 2023 Jul 20;13(14).
- Diaz-Falcon N, Clark-Price S, Holland M, Johnson J, Lascola K. Ultrasound dilution cardiac output and echocardiography findings in anesthetized mature alpacas (Vicugna pacos) during normotension, hypotension and hypertension. PLoS One 2023;18(4):e0284299.
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