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Comparative immunology, microbiology and infectious diseases1994; 17(3-4); 297-303; doi: 10.1016/0147-9571(94)90049-3

Diagnosis of African horsesickness.

Abstract: African horsesickness (AHS) is a very serious, non-contagious disease of horses and other solipeds caused by an arthropod-borne orbivirus of the family Reoviridae. The epizootic nature of the disease makes rapid, accurate diagnosis of AHS absolutely essential. Currently, diagnosis of AHS is based on typical clinical signs and lesions, a history consistent with vector transmission and confirmation by laboratory detection of virus and/or anti-AHS virus antibodies. The clinicopathologic presentation of AHS, current and next generation laboratory diagnostic methods are discussed.
Publication Date: 1994-08-01 PubMed ID: 8001351DOI: 10.1016/0147-9571(94)90049-3Google Scholar: Lookup
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Summary

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The research article discusses African horsesickness (AHS), a serious disease in horses and similar species, its diagnosis methods, and discusses new potential approaches for diagnosing this ailment.

Understanding African Horsesickness (AHS)

African horsesickness is a severe disease that affects horses and other similar species, like donkeys and zebras. It’s described as non-contagious, meaning it doesn’t spread directly from one animal to another. Instead, it’s transmitted by arthropods, like midges. AHS is part of the Reoviridae family, which contains many different viruses known to affect a variety of hosts.

  • The disease is considered serious due to its epizootic nature, meaning it can cause sudden and severe outbreaks in animal populations.
  • The illness is frequently fatal, with death potentially occurring as quickly as two days following the onset of clinical signs.

Current Diagnostic Methods

At present, the diagnosis of AHS is primarily grounded on a combination of symptomatic evidence, historical information, and laboratory confirmation.

  • Clinical signs of AHS may include fever, difficulty breathing, swelling of the eyes or head, and sometimes sudden death.
  • An animal’s history, particularly whether it has been in an area where the transmitting vector is known to be present, is another important diagnostic consideration.
  • Finally, lab testing is used to detect the presence of the virus and/or antibodies against it, which conclusively confirms the diagnosis.

Future Diagnostic Methods

The article also delves into discussing upcoming diagnostic methods for AHS. Although the paper does not go into specific details about these next-generation methods, the importance of more rapid and accurate diagnostic tools is stressed.

  • Having a quicker diagnosis of AHS would allow for earlier treatment and potentially better prognosis for the affected animals.
  • More accurate diagnostics would prevent false positives and negatives – ensuring that only affected animals are treated, and all sick animals are diagnosed.

Cite This Article

APA
Laegreid WW. (1994). Diagnosis of African horsesickness. Comp Immunol Microbiol Infect Dis, 17(3-4), 297-303. https://doi.org/10.1016/0147-9571(94)90049-3

Publication

ISSN: 0147-9571
NlmUniqueID: 7808924
Country: England
Language: English
Volume: 17
Issue: 3-4
Pages: 297-303

Researcher Affiliations

Laegreid, W W
  • Molecular Pathology Unit, Plum Island Animal Disease Center, USDA/ARS, Greenport, NY 11944-0848.

MeSH Terms

  • African Horse Sickness / diagnosis
  • African Horse Sickness Virus / genetics
  • African Horse Sickness Virus / immunology
  • African Horse Sickness Virus / isolation & purification
  • Animals
  • Antibodies, Viral / analysis
  • Antigens, Viral / analysis
  • RNA, Viral / analysis
  • Virology / methods

Citations

This article has been cited 1 times.
  1. Tinarwo M, Dennis SJ, Hitzeroth II, Meyers AE, Rybicki EP, Mbewana S. Development of an African horse sickness VP6 DIVA diagnostic ELISA. Virol J 2025 Aug 12;22(1):276.
    doi: 10.1186/s12985-025-02898-1pubmed: 40796889google scholar: lookup