Diagnostic value of intestinal alkaline phosphatase in horse serum.
Abstract: Antiserum directed against equine intestinal Alkaline Phosphatase (ALP) was produced in rabbits and used to develop a sensitive and quantitative assay for the detection of intestinal ALP in equine serum. This assay was then used to measure the half-life of intravenously injected intestinal ALP and to determine if the intestinal ALP was present in normal horse sera, sera from horses presented for lesions not involving the gastrointestinal tract and sera from horses presented with lesions involving the gastrointestinal tract. The results suggest that intestinal ALP is not likely to appear in equine serum even when gastrointestinal disease is present and, therefore, appears to be of no diagnostic value.
Publication Date: 1983-01-01 PubMed ID: 15311398DOI: 10.1111/j.1939-165x.1983.tb00613.xGoogle Scholar: Lookup
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- Journal Article
Summary
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This research is about the development of a test for equine intestinal Alkaline Phosphatase (ALP) and its potential use for diagnosing gastrointestinal disease in horses. The study concluded, however, that presence of ALP in serum is not a reliable diagnostic marker for such diseases.
Introduction
- The researchers created antiserum against equine intestinal Alkaline Phosphatase (ALP) in rabbits.
- This was done to develop a sensitive and quantitative test for the detection of intestinal ALP in equine serum.
Method
- The developed test was used to measure the half-life of intravenously injected intestinal ALP in horses.
- It was also applied to determine the presence of intestinal ALP in different types of horse serum: from healthy horses, from horses with non-gastrointestinal lesions and from horses with gastrointestinal lesions.
Results
- The results showed that the intestinal ALP is not likely to appear in equine serum even when the horse is suffering from a gastrointestinal disease.
Conclusion
- Thus, the study concluded that intestinal ALP detection in equine serum is not a reliable diagnostic marker for gastrointestinal diseases in horses.
Cite This Article
APA
Hoffmann WE, Dorner JL, Morris H.
(1983).
Diagnostic value of intestinal alkaline phosphatase in horse serum.
Vet Clin Pathol, 12(2), 33-38.
https://doi.org/10.1111/j.1939-165x.1983.tb00613.x Publication
Researcher Affiliations
- Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana, Illinois 61801.
Citations
This article has been cited 3 times.- Ellison RS, Jacobs RM. The isoelectric focusing properties of serum alkaline phosphatase in disease and following prednisolone and phenylbutazone administration in the horse. Can J Vet Res 1990 Jan;54(1):126-31.
- Ellison RS, Jacobs RM. An attempt to determine the tissue origin of equine serum alkaline phosphatase by isoelectric focusing. Can J Vet Res 1990 Jan;54(1):119-25.
- Harari S, Deretz S, Dumont Saint Priest B, Richard E, Ricard A. Comparison of blood parameters in two genetically different groups of horses for functional longevity in show jumping. Front Genet 2024;15:1455790.
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