Digitoxin metabolism by rat liver microsomes.
Abstract: The chest roentgenographic findings in Takayasu's arteritis include widening of the ascending aorta, contour irregularities of the descending aorta, arotic calcifications, pulmonary arterial changes, rib notching, and hilar lymphadenopathy. The single most important diagnostic sign is a segmental calcification outlining a localized or diffuse narrowing of the aorta. The other signs may be suspicious or suggestive, but the diagnostic accuracy increases when several findings are present simultaneously. A routine screening of monoclonal gammopathies (M.G.) was performed in the serum from 36, 015 blood donors by cellulose acetate electrophoresis. The incidence of M.G. was estimated to 0.14 per cent. About 86 per cent of cases can be classified as asymptomatic M.G. and 14 per cent as malignant M.G. (myeloma or Waldenström macroglobulinemia). In asymptomatic forms, heavy chain classes are only IgG or IgM with a large predominance of IgG (86,4%). It is suggested that donors in whom M.G. have been detected should not be allowed to give blood. A yearly clinical, hematological and an immunoglobulin check-up is recommended to these patients in order to defect the first sign of a malignant process.
Publication Date: 1975-09-01 PubMed ID: http://doi.org/10.1016/j.jevs.2023.104374DOI: 10.1016/0006-291x(75)90337-xGoogle Scholar: Lookup
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Summary
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The research examines Digitoxin metabolism in rat liver microsomes, explores chest roentgenographic findings in Takayasu’s arteritis, and then investigates the incidence of monoclonal gammopathies (M.G.) in blood donors. It concludes with recommendations on how to handle blood donors identified with M.G.
Digitoxin Metabolism in Rat Liver Microsomes
- This study begins by exploring the metabolism of Digitoxin in rat liver microsomes but does not provide further insights or outcomes from this part of the research.
Roentgenographic Findings in Takayasu’s Arteritis
- The study describes the different radiographic signs seen in Takayasu’s arteritis, an inflammatory disease of the aorta, including a widened ascending aorta, irregular descending aorta contours, aortic calcifications, changes in pulmonary arteries, rib notching, and hilar lymphadenopathy.
- Segmental calcifications that outline localized or diffuse aortic narrowing are described as the most indicative of the disease.
- While other signs may point towards a diagnosis of Takayasu’s arteritis, the research emphasizes that the presence of several simultaneously can increase confidence in the diagnosis.
Monoclonal Gammopathies in Blood Donors
- The researchers also looked at the occurrence of monoclonal gammopathies (M.G.), abnormal proteins produced by a clone of plasma cells, in the blood of 36,015 donors.
- The incidence of M.G. was found to be 0.14%, with the majority of these (86%) being asymptomatic and 14% being malignant (myeloma or Waldenström macroglobulinemia).
- In asymptomatic cases, the heavy chain classes were mainly IgG or IgM, with a large predominance of IgG (86.4%).
Recommendations for Blood Donors with Monoclonal Gammopathies
- The paper suggests that blood donors in whom M.G. have been detected should be disallowed from donating blood.
- Furthermore, those identified with M.G. are recommended to have an annual clinical, hematological, and immunoglobulin check-up to detect the first signs of any malignant process.
Cite This Article
APA
Schmoldt A, Benthe HF, Haberland G, Tarentino AL, Maley F, Berkmen YM, Lande A, Fine JM, Lambin P, Derycke C, North ML, Chataing B, Goudemand M.
(1975).
Digitoxin metabolism by rat liver microsomes.
Biochem Pharmacol, 24(17), 1639-1641.
https://doi.org/10.1016/0006-291x(75)90337-x Publication
Researcher Affiliations
MeSH Terms
- Animals
- Chromatography, Thin Layer
- Digitoxigenin / metabolism
- Digitoxin / metabolism
- Hydroxylation
- In Vitro Techniques
- Male
- Microsomes, Liver / metabolism
- NADP / metabolism
- Rats
- Time Factors
- Acetylglucosaminidase / metabolism
- Fucose
- Hexosaminidases / metabolism
- Kinetics
- Oligosaccharides
- Species Specificity
- Streptococcus pneumoniae / enzymology
- Streptomyces griseus / enzymology
- Structure-Activity Relationship
- Adolescent
- Adult
- Aorta / abnormalities
- Aortic Arch Syndromes / diagnostic imaging
- Arteritis
- Calcinosis / diagnostic imaging
- Female
- Humans
- Hypertension, Pulmonary / diagnostic imaging
- Lymphatic Diseases / diagnostic imaging
- Middle Aged
- Radiography
- Ribs / abnormalities
- Takayasu Arteritis / diagnosis
- Takayasu Arteritis / diagnostic imaging
- United States
- Adult
- Blood Donors
- Electrophoresis, Cellulose Acetate
- Humans
- Hypergammaglobulinemia / blood
- Hypergammaglobulinemia / epidemiology
- Immunoglobulin G / analysis
- Immunoglobulin kappa-Chains / analysis
- Immunoglobulin lambda-Chains / analysis
- Mass Screening
- Middle Aged
Grant Funding
- K01 AG044439 / NIA NIH HHS
- HERU1 / Chief Scientist Office
Citations
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