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Dobutamine use in horses during romifidine and isoflurane anaesthesia.
Abstract: This retrospective study aimed to assess the incidence of hypotension and the subsequent administration of dobutamine in horses anesthetized with isoflurane and romifidine during elective surgery. Time from induction of anaesthesia to administration of dobutamine was registered, as well as the time and dose needed to restore mean arterial pressure (MAP) ≥ 70 mmHg. Additionally, the influence of patient and anaesthesia related parameters on the need for dobutamine supplementation was evaluated. In total, 118 horses were included in this retrospective study. Dobutamine was administered to effect when MAP<70 mmHg. Data registered: patient weight, acepromazine premedication, body position, administration of intraoperative ketamine bolus, locoregional anaesthesia, mechanical ventilation, duration of anaesthesia, dose and duration of dobutamine administration, heart rate, MAP before dobutamine administration, MAP and time required to increase MAP≥70 mmHg. Dobutamine infusion was needed in 54.2% of the horses 30 ± 17 min after isoflurane-romifidine anaesthesia started. Dobutamine 0.55 ± 0.18 μg kg min achieved a MAP≥70 mmHg in 12 ± 8 min. Duration of dobutamine infusion was 56 ± 37 min. An univariable logistic regression showed a significant association between dobutamine and acepromazine administration (p = 0.01; OR = 3.43), anaesthesia time (p = 0.02; OR = 2.41) and dorsal recumbency (p < 0.001; OR = 8.40). In a multivariable logistic regression, only dorsal recumbency significantly increased the need for dobutamine supplementation (p < 0.001; OR = 7.70). There was no significant association between patient weight (p = 0.11; OR = 1), locoregional anaesthesia (p = 0.07; OR = 0.47), administration of a ketamine bolus (p = 0.95; OR = 0.98) or volume controlled ventilation (p = 0.94; OR = 1.04) and dobutamine administration. Low doses of dobutamine were suitable to restore MAP above 70 mmHg within a limited time period. Only dorsal recumbency increased the need of dobutamine administration.
Copyright © 2023 Elsevier Ltd. All rights reserved.
Publication Date: 2023-12-22 PubMed ID: 38154415DOI: 10.1016/j.rvsc.2023.105119Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
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The research involves a retrospective study assessing the occurrence of low blood pressure during horse surgery under anesthesia with isoflurane and romifidine, and the subsequent use of a drug called dobutamine. The study also explores the impact of certain factors on the necessity of dobutamine administration.
Objective of the Study
- This study aims to evaluate the occurrence of hypotension (low blood pressure) and the need for dobutamine in horses anesthetized with isoflurane and romifidine during elective surgery.
Methodology
- A total of 118 horses were included in this retrospective study.
- Data related to patient weight, acepromazine premedication, body position, intraoperative ketamine bolus, locoregional anesthesia, mechanical ventilation, duration of anesthesia, dose and duration of dobutamine administration, heart rate, and mean arterial pressure (MAP) before and after dobutamine were recorded.
- Dobutamine was administered at the point where the mean arterial pressure (MAP) dropped below 70 mmHg.
findings
- Dobutamine infusion was required in 54.2% of the cases, approximately 30 minutes after the anesthesia had started.
- In terms of dosage, a rate of 0.55 μg kg min was successful in restoring MAP above 70 mmHg in about 12 minutes. The infusion duration was generally 56 minutes.
- Based on regression analysis, there was a significant link between the use of dobutamine and acepromazine (p = 0.01; odds ratio (OR) = 3.43), duration of anesthesia (p = 0.02; OR = 2.41) and the horse’s dorsal recumbency condition (p < 0.001; OR = 8.40).
- In multivariable logistic regression analysis, only the horse’s dorsal recumbency was found to significantly increase the need for dobutamine (p < 0.001; OR = 7.70).
Conclusion
- The administration of low doses of dobutamine proved effective in restoring MAP above 70 mmHg within a short time.
- The only factor that increased the need for dobutamine was dorsal recumbency.
Cite This Article
APA
Ruíz-López P, Schauvliege S, Gasthuys F, Haspeslagh M.
(2023).
Dobutamine use in horses during romifidine and isoflurane anaesthesia.
Res Vet Sci, 167, 105119.
https://doi.org/10.1016/j.rvsc.2023.105119 Publication
Researcher Affiliations
- Department of Large Animal Surgery, Anaesthesia and Orthopaedics, Faculty of Veterinary Medicine, University of Ghent, Salisburylaan 133, 9820 Merelbeke, Belgium. Electronic address: ruizlopezpatricia@gmail.com.
- Department of Large Animal Surgery, Anaesthesia and Orthopaedics, Faculty of Veterinary Medicine, University of Ghent, Salisburylaan 133, 9820 Merelbeke, Belgium.
- Department of Large Animal Surgery, Anaesthesia and Orthopaedics, Faculty of Veterinary Medicine, University of Ghent, Salisburylaan 133, 9820 Merelbeke, Belgium.
- Department of Large Animal Surgery, Anaesthesia and Orthopaedics, Faculty of Veterinary Medicine, University of Ghent, Salisburylaan 133, 9820 Merelbeke, Belgium.
Conflict of Interest Statement
Declaration of Competing Interest This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
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