Double-blinded placebo-controlled clinical field trial to evaluate the safety and efficacy of topically applied 1% diclofenac liposomal cream for the relief of lameness in horses.

This study investigates the effect of a topical 1% diclofenac liposomal cream on alleviating lameness in horses, confirming it as safe, user-friendly, and successful in combating disability due to degenerative joint disease.

Overview of the Research

• The research conducted a double-blinded placebo-controlled clinical field trial to evaluate the safety and efficacy of topically applied 1% diclofenac liposomal cream on lame horses.
• The horses suffered from various degrees of lameness attributed to degenerative joint disease; a common chronic condition in horses that results in pain and reduced mobility.

Efficacy of Diclofenac Liposomal Cream

• The study found that the use of Diclofenac Liposomal Cream successfully reduced lameness in horses, as reported both by owners and veterinarians, regardless of the severity or chronicity of the clinical condition. This implies that the drug was effective across different stages and severities of the disease.
• The method of application was also beneficial as a topical application is often easier and more convenient than oral or injectable methods. This increases the likelihood of consistent and proper usage.

Safety of Diclofenac Liposomal Cream

• The cream did not cause any clinically significant changes in hematological or serum biochemical levels, affirming its safety for use in horses.
• Diclofenac Liposomal Cream provides a delivery system for Diclofenac, a non-steroidal anti-inflammatory drug (NSAID). This helps achieve therapeutic levels locally, minimizing systemic toxicity and side effects. This means it is more targeted and less likely to affect other body systems or cause undesired reactions.

Significance of the Findings

• This research is significant as it proposes a safe, effective, and convenient therapeutic option for managing lameness in horses due to degenerative joint disease. It can drastically improve the quality of life for these animals.
• Furthermore, the study also provides an instance where topical application can be just as or even more beneficial than traditional oral or injectable forms, broadening the scope and potential applications of drug delivery systems.