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Home / Equine Research Bank / Nucleic Acids Res / DrugCentral 2023 extends human clinical data and integrates ...
Nucleic acids research2022; 51(D1); D1276-D1287; doi: 10.1093/nar/gkac1085

DrugCentral 2023 extends human clinical data and integrates veterinary drugs.

Abstract: DrugCentral monitors new drug approvals and standardizes drug information. The current update contains 285 drugs (131 for human use). New additions include: (i) the integration of veterinary drugs (154 for animal use only), (ii) the addition of 66 documented off-label uses and iii) the identification of adverse drug events from pharmacovigilance data for pediatric and geriatric patients. Additional enhancements include chemical substructure searching using SMILES and 'Target Cards' based on UniProt accession codes. Statistics of interests include the following: (i) 60% of the covered drugs are on-market drugs with expired patent and exclusivity coverage, 17% are off-market, and 23% are on-market drugs with active patents and exclusivity coverage; (ii) 59% of the drugs are oral, 33% are parenteral and 18% topical, at the level of the active ingredients; (iii) only 3% of all drugs are for animal use only; however, 61% of the veterinary drugs are also approved for human use; (iv) dogs, cats and horses are by far the most represented target species for veterinary drugs; (v) the physicochemical property profile of animal drugs is very similar to that of human drugs. Use cases include azaperone, the only sedative approved for swine, and ruxolitinib, a Janus kinase inhibitor.
© The Author(s) 2022. Published by Oxford University Press on behalf of Nucleic Acids Research.
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Publication Date: 2022-12-10 PubMed ID: 36484092PubMed Central: PMC9825566DOI: 10.1093/nar/gkac1085Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The study involves an updated database called DrugCentral 2023 that encompasses new drug approvals and standardizes their information. The database now includes data on both human and veterinary drugs, documented off-label uses of drugs, and identification of adverse drug reactions from specific group of patients.

Integration of Veterinary Drugs

  • The latest update of DrugCentral includes 131 new drugs that are approved for human use and 154 which are used solely for animals.
  • The integration of veterinary drugs into the database significantly broadens its scope and usability, especially in terms of animal healthcare and wellness programs.

Off-Label Drug Uses and Adverse Events Data

  • This update also incorporates 66 documented off-label uses of drugs. Off-label uses refer to the use of approved drugs in a manner that is not specified in the approved product label.
  • The DrugCentral 2023 database also identifies and records adverse drug events drawn from pharmacovigilance data, with particular attention to pediatric and geriatric patients. Recognizing these events can help prevent such occurrences in these vulnerable groups in the future as well as aid in formulating precautionary measures.

New Features of DrugCentral 2023

  • Several other new features have been included in the database, such as the ability to carry out chemical substructure searches using Simplified Molecular Input Line Entry System (SMILES) codes, and ‘Target Cards’ based on UniProt accession codes.
  • This means users can search for information about a drug or a drug substructure by entering its unique SMILES string or UniProt code, respectively. This further improves the usability and versatility of the database.

Statistics and Drug Profile

  • The database includes detailed statistics of the listed drugs. For instance, it shows that 60% of them are market drugs whose patent and exclusivity have expired. However, active patents and exclusivity cover 23% of on-market drugs while 17% are off-market.
  • Moreover, the database reveals that 59% of the drugs are oral, 33% are parenteral (administered or occurring elsewhere in the body than the mouth and alimentary canal), and 18% are topical.
  • Interestingly, while only 3% of all drugs are exclusively for animal use, 61% of these veterinary drugs are also approved for use in humans. This highlights the crossover of many drugs between human and animal therapy.
  • Among the animal drugs, the most common target species are dogs, cats, and horses.
  • The physicochemical profiles of drugs meant for animals are found to be similar to those for human drugs, reinforcing the idea that many drugs used in veterinary medicine have potential applications in human medicine too.

Use Cases

  • Notable use cases include azaperone, the only sedative approved for use in pigs, and ruxolitinib, a Janus kinase inhibitor.

Cite This Article

APA
(2022). DrugCentral 2023 extends human clinical data and integrates veterinary drugs. Nucleic Acids Res, 51(D1), D1276-D1287. https://doi.org/10.1093/nar/gkac1085

Publication

Nucleic acids research
ISSN: 1362-4962
NlmUniqueID: 0411011
Country: England
Language: English
Volume: 51
Issue: D1
Pages: D1276-D1287

Researcher Affiliations

MeSH Terms

  • Animals
  • Humans
  • Drug Approval
  • Drug-Related Side Effects and Adverse Reactions / veterinary
  • Veterinary Drugs / administration & dosage
  • Veterinary Drugs / adverse effects
  • Off-Label Use / veterinary

Grant Funding

  • U24 CA224370 / NCI NIH HHS

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