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Effect of constant rate infusion of detomidine with and without vatinoxan on blood glucose and insulin concentrations in horses.
Abstract: To assess the effects of an α-adrenoceptor agonist (detomidine) constant rate infusion (CRI) with and without an α-adrenoceptor antagonist (vatinoxan) CRI on blood insulin and glucose concentrations, heart rate, intestinal borborygmi, and sedation during and after infusion in horses. Methods: Randomized, blinded, crossover, experimental study. Methods: A total of nine healthy, adult Finnhorse mares. Methods: Horses were treated with an intravenous (IV) detomidine loading dose (0.01 mg kg), followed by CRI (0.015 mg kg hour), and the same doses of detomidine combined with an IV vatinoxan loading dose (0.15 mg kg), followed by CRI (detomidine and vatinoxan; 0.05 mg kg hour) with an 18 day washout period. Infusion time was 60 minutes and horses were monitored for 240 minutes after the infusion. Heart rate, borborygmi score and sedation were assessed, and blood glucose, insulin and triglyceride concentrations were measured. Data were analyzed using repeated measures ancova and Wilcoxon signed-rank tests. Values of p < 0.05 were considered statistically significant. Results: Insulin concentration decreased during (median nadir 1.7, range 0.0-2.9 μIU mL at 60 minutes, p < 0.0001) and increased after detomidine CRI (median 36.6, range 11.7-78.4 μIU mL at 180 minutes, p = 0.0001) significantly compared with detomidine and vatinoxan CRI. A significant elevation of blood glucose (peak 11.5 ± 1.6 mmol L at 60 minutes, p < 0.0001) was detected during detomidine CRI. Vatinoxan alleviated the insulin changes and abolished the significant increase in blood glucose. Vatinoxan alleviated the decrease in heart rate (p = 0.0001) during detomidine infusion. No significant differences were detected in sedation scores between treatments. Conclusions: Vatinoxan attenuated the negative adverse effects of detomidine CRI and thus is potentially beneficial when used in combination with an α-adrenoceptor agonist CRI in horses.
Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.
Publication Date: 2023-11-19 PubMed ID: 38103967DOI: 10.1016/j.vaa.2023.11.005Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
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The study focuses on the impact of the infusion of detomidine, with and without vatinoxan, on the concentration of glucose and insulin in horse’s blood. It looks into the effects on the heart rate, borborygmus (intestinal noise), and sedation experienced during and after the infusion.
Methodology
- The study was performed on nine healthy, adult Finnhorse mares through a randomized, blinded, crossover, and experimental design.
- The horses were given an initial intravenous dose of detomidine, followed by a constant rate infusion. This was also done with a combination of detomidine and vatinoxan, with a detox period of 18 days.
- The infusion took place for 60 minutes and the horses were monitored for 240 minutes after the infusion.
- During this period, assessments were made on the heart rate, borborygmi score, and level of sedation. The concentrations of glucose, insulin, and triglycerides were also measured.
- Statistical analysis was carried out using repeated measures ancova and Wilcoxon signed-rank tests.
Findings
- The concentration of insulin decreased during and increased after the detomidine infusion significantly in comparison with the infusion of both detomidine and vatinoxan.
- Blood glucose significantly increased during detomidine infusion. However, vatinoxan lessened the insulin changes and the substantial increase in blood glucose was abolished.
- Vatinoxan also alleviated the decrease in the heart rate during detomidine infusion.
- There were no significant differences found in sedation scores between treatments.
Conclusion
- The study concludes that vatinoxan attenuates the negative effects of the constant rate infusion of detomidine. This suggests benefits when used in combination with an α-adrenoceptor agonist for horses during constant rate infusion.
Cite This Article
APA
Hallman I, Tapio H, Raekallio M, Karikoski N.
(2023).
Effect of constant rate infusion of detomidine with and without vatinoxan on blood glucose and insulin concentrations in horses.
Vet Anaesth Analg, S1467-2987(23)00359-8.
https://doi.org/10.1016/j.vaa.2023.11.005 Publication
Researcher Affiliations
- Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland. Electronic address: isa.hallman@helsinki.fi.
- Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.
- Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.
- Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.
Citations
This article has been cited 2 times.- Van den Branden E, Salamone M, Broothaers K, Peere S, Polfliet E, Dewulf M, Van Steenkiste G, van Loon G, Smits K, Govaere J. Physiological and behavioral parameters of pain and stress in mares during and after transvaginal ultrasound-guided follicular aspiration. Front Vet Sci 2025;12:1574351.
- Vullo C, Gugliandolo E, Biondi V, Biffarella M, Catone G, Tambella AM. Comparison of Detomidine or Romifidine in Combination with Morphine for Standing Magnetic Resonance Imaging in Horses. Vet Sci 2024 Mar 8;11(3).
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