Effect of intraperitoneal PERIDAN™ concentrate adhesion reduction device on clinical findings, infection, and tissue healing in an adult horse jejunojejunostomy model.

The research paper evaluated the effects of a product called PERIDAN™ Concentrate when used during a specific type of horse surgery. The study found that the product did not have a significant impact on the horse’s overall health or the success of the surgical procedure.

Research Method

• The researchers conducted a block randomized blinded experimental in vivo study on 12 adult horses. In other words, the experiment was designed to mimic as much as possible the conditions under which the treatment would be used in the real world, and neither the subjects nor the researchers knew which treatment the subjects were receiving (PERIDAN™ or a control solution).
• The horses had two sites of jejunojejunostomy, which is a surgical procedure to connect two parts of the jejunum, an area of the small intestine. This is typically done in situations where parts of the intestine have been damaged and need to be bypassed.
• Half of the horses were given the PERIDAN™ Concentrate diluted in 5 liters of fluid, while the other half were given a Lactated Ringer’s Injection as a control.
• After the surgery, the horses were monitored through physical exams, blood work, and ultrasounds. After 10 days, the horses were euthanized and the surgical sites were tested for strength, inflammation, and infection.

Research Findings

• Based on the physical examinations, there were no noticeable differences between the groups. While there were statistical differences in some blood work results and in the strength of some of the surgical incisions, these differences were minimal and didn’t seem to have a clinical significance. This suggests that the product didn’t negatively impact surgery or recovery.
• Other measurements, including other blood variables and signs of inflammation and infection, did not differ significantly between the groups. This further supports the conclusion that the product was safe to use.

Overall Interpretation

• In conclusion, the administration of PERIDAN™ Concentrate intraperitoneally in horses undergoing celiotomy and anastomosis was evaluated to be safe. These findings suggest that the product could be used in a clinical setting without undue risk to the horse.