Effects of lidocaine infusion during experimental endotoxemia in horses.
Abstract: The clinical efficacy of IV infusion of lidocaine for treatment of equine endotoxemia has not been studied. Objective: Lidocaine infusion after exposure to lipopolysaccharide (LPS) will inhibit the inflammatory response and have inhibitory effects on the hemodynamic and cytokine responses to endotoxemia. Methods: Twelve horses. Methods: Two equal groups (n=6): saline (GI) and lidocaine (GII). In all animals, endotoxin (500 ng/kg body weight [BW]) was injected intraperitoneally over 5 minutes. Twenty minutes later, animals received a bolus of GI or GII (1.3 mg/kg BW) over 5 minutes, followed by a 6-hour continuous rate infusion of GI or GII (0.05 mg/kg BW/min). Treatment efficacy was judged from change in arterial blood pressure, peripheral blood and peritoneal fluid (PF) variables (total and differential cell counts, enzyme activities, and cytokine concentrations), and clinical scores (CS) for behavioral evidence of abdominal pain or discomfort during the study. Results: Compared with the control group, horses treated with lidocaine had significantly lower CS and serum and PF tumor necrosis factor-alpha (TNF-alpha) activity. At several time points in both groups, total and differential cell counts, glucose, total protein and fibrinogen concentrations, and alkaline phosphatase, creatine kinase, and TNF-alpha activities were significantly different from baseline values both in peripheral blood and in PF. Conclusions: Lidocaine significantly decreased severity of CS and inhibited TNF-alpha activity in PF.
Publication Date: 2010-07-24 PubMed ID: 20649751DOI: 10.1111/j.1939-1676.2010.0555.xGoogle Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Controlled Clinical Trial
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research article basically investigates the effectiveness of intravenous lidocaine infusion in treating endotoxemia in horses. It concludes that lidocaine significantly reduces the severity of clinical scores and inhibits TNF-alpha activity in peritoneal fluid.
Methodology
- The researchers used a total of twelve horses for this experimental study. These horses were divided into two equal groups: Group I was treated with saline while Group II was treated with lidocaine.
- Endotoxin, a toxin that is present inside a bacterial cell and is released when the cell disintegrates, was injected into all the horses over a five minute span.
- After twenty minutes, the horses from both groups received either a bolus of saline or lidocaine over another five minute span. This was followed by a six hour continuous infusion of the same.
Procedure
- The researchers judged the effectiveness of the treatment methods by monitoring the change in arterial blood pressure, peripheral blood and peritoneal fluid variables, and clinical scores that were taken into account for behavioral evidence of abdominal pain or discomfort during the duration of the study.
Results
- The results of this study showed that horses treated with lidocaine had significantly lower clinical scores and serum and peritoneal fluid tumor necrosis factor-alpha (TNF-alpha) activity as compared to the control group.
- At various time frames in both groups, total and differential cell counts, glucose, total protein and fibrinogen concentrations, and alkaline phosphatase, creatine kinase, and TNF-alpha activities were significantly different from the baseline values both in peripheral blood and peritoneal fluid.
Conclusions
- The researchers concluded that the administration of lidocaine significantly decreased the severity of the clinical scores and inhibited the TNF-alpha activity in the peritoneal fluid, indicating that it can be an effective treatment for equine endotoxemia.
Cite This Article
APA
Peiró JR, Barnabé PA, Cadioli FA, Cunha FQ, Lima VM, Mendonça VH, Santana AE, Malheiros EB, Perri SH, Valadão CA.
(2010).
Effects of lidocaine infusion during experimental endotoxemia in horses.
J Vet Intern Med, 24(4), 940-948.
https://doi.org/10.1111/j.1939-1676.2010.0555.x Publication
Researcher Affiliations
- Department of Clinics, Surgery, and Animal Reproduction, Univ Estadual Paulista (UNESP), Araçatuba, SP, Brazil. jpeiro@fmva.unesp.br
MeSH Terms
- Animals
- Endotoxemia / chemically induced
- Endotoxemia / veterinary
- Endotoxins / toxicity
- Horse Diseases / chemically induced
- Horses
- Injections, Intravenous
- Lidocaine / administration & dosage
- Lidocaine / therapeutic use
- Male
- Tumor Necrosis Factor-alpha / blood
- Tumor Necrosis Factor-alpha / metabolism
Citations
This article has been cited 11 times.- Marques AEGW, Marques MG, Silveira BCR, Oliveira SP, Ferraz IG, Ventricci ABG, Silva NC, Nagata WB, Floriano BP, Ferreira WL, Santos PSP. Lidocaine administered at a continuous rate infusion does not impair left ventricular systolic and diastolic function of healthy rabbits sedated with midazolam. Vet Anim Sci 2020 Dec;10:100151.
- Bauquier J, Tudor E, Bailey S. Effect of the p38 MAPK inhibitor doramapimod on the systemic inflammatory response to intravenous lipopolysaccharide in horses. J Vet Intern Med 2020 Sep;34(5):2109-2116.
- Mendoza Garcia FJ, Gonzalez-De Cara C, Aguilera-Aguilera R, Buzon-Cuevas A, Perez-Ecija A. Meloxicam ameliorates the systemic inflammatory response syndrome associated with experimentally induced endotoxemia in adult donkeys. J Vet Intern Med 2020 Jul;34(4):1631-1641.
- Fielding CL. Practical Fluid Therapy and Treatment Modalities for Field Conditions for Horses and Foals with Gastrointestinal Problems. Vet Clin North Am Equine Pract 2018 Apr;34(1):155-168.
- Zhang Y, Tao GJ, Hu L, Qu J, Han Y, Zhang G, Qian Y, Jiang CY, Liu WT. Lidocaine alleviates morphine tolerance via AMPK-SOCS3-dependent neuroinflammation suppression in the spinal cord. J Neuroinflammation 2017 Nov 2;14(1):211.
- Klein JA, Langman LJ. Prevention of Surgical Site Infections and Biofilms: Pharmacokinetics of Subcutaneous Cefazolin and Metronidazole in a Tumescent Lidocaine Solution. Plast Reconstr Surg Glob Open 2017 May;5(5):e1351.
- Schnabel CL, Steinig P, Koy M, Schuberth HJ, Juhls C, Oswald D, Wittig B, Willenbrock S, Murua Escobar H, Pfarrer C, Wagner B, Jaehnig P, Moritz A, Feige K, Cavalleri JM. Immune response of healthy horses to DNA constructs formulated with a cationic lipid transfection reagent. BMC Vet Res 2015 Jun 23;11:140.
- Pihl TH, Scheepers E, Sanz M, Goddard A, Page P, Toft N, Andersen PH, Jacobsen S. Influence of disease process and duration on acute phase proteins in serum and peritoneal fluid of horses with colic. J Vet Intern Med 2015 Mar-Apr;29(2):651-8.
- Krueger CR, Ruple-Czerniak A, Hackett ES. Evaluation of plasma muscle enzyme activity as an indicator of lesion characteristics and prognosis in horses undergoing celiotomy for acute gastrointestinal pain. BMC Vet Res 2014;10 Suppl 1(Suppl 1):S7.
- Sousa LN, Winter IC, Varela DD, Luvison EZ, Guzmán JFC, Machado AMV, Figueiredo RDV, Pena GT, Dos Santos ACS, Faleiros RR, Carvalho AM. Lidocaine's Ineffectiveness in Mitigating Lipopolysaccharide-Induced Pain and Peristaltic Effects in Horses. Animals (Basel) 2024 Nov 2;14(21).
- Brunner A, Lehmann A, Hettlich B, Peters LM, Doras CJ, Adamik KN. Inflammatory biomarker concentrations in dogs with gastric dilatation volvulus with and without 24-h intravenous lidocaine. Front Vet Sci 2023;10:1287844.
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists
