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Home / Equine Research Bank / J Vet Sci / Effects of mosapride on motility of the small intestine and ...
Journal of veterinary science2009; 10(2); 157-160; doi: 10.4142/jvs.2009.10.2.157

Effects of mosapride on motility of the small intestine and caecum in normal horses after jejunocaecostomy.

Abstract: The purpose of the present study was to evaluate the prokinetic effects of mosapride with non-invasive assessment of myoelectrical activity in the small intestine and caecum of healthy horses after jejunocaecostomy. Six horses underwent celiotomy and jejunocaecostomy, and were treated with mosapride (treated group) at 1.5 mg/kg per osos once daily for 5 days after surgery. The other six horses did not receive treatment and were used as controls (non-treated group). The electrointestinography (EIG) maximum amplitude was used to measure intestinal motility. Motility significantly decreased following surgery. In the treated group, the EIG maximum amplitude of the small intestine was significantly higher than in the controls from day 6 approximately 31 after treatment. These findings clearly indicate that mosapride could overcome the decline of intestinal motility after jejunocaecostomy in normal horses.
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Publication Date: 2009-05-23 PubMed ID: 19461212PubMed Central: PMC2801111DOI: 10.4142/jvs.2009.10.2.157Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research evaluated the effects of a drug called mosapride on the intestinal movement of healthy horses following a surgical procedure known as jejunocaecostomy. The results indicated that mosapride could help enhance the motility of the intestine post-surgery.

Study Design and Procedure

  • The study involved twelve healthy horses which were divided into two groups: a control group which did not receive any treatment, and a treated group which was administered mosapride.
  • The horses all underwent a surgical procedure called jejunocaecostomy. This is a specific type of surgery performed on the intestines.
  • The horses in the treatment group were given mosapride, a prokinetic drug that stimulates gastrointestinal motility, at a dose of 1.5 mg/kg per osos daily for five days following the surgery.

Data Collection and Analysis

  • The researchers used electrointestinography (EIG), a non-invasive method of assessing intestinal motility, to measure the effectiveness of mosapride.
  • The maximum amplitude of the EIG was used to determine the level of motility in the intestines.
  • It was found that intestinal motility decreased significantly after surgery in all the horses.

Findings

  • In comparison to the control group, the treated group that received mosapride showed markedly improved intestinal motility from the 6th day till about the 31st day post the jejunocaecostomy procedure.
  • This suggests that mosapride has potential as a therapeutic agent to boost intestinal motility after intestinal surgeries like jejunocaecostomy in horses.

Cite This Article

APA
Okamura K, Sasaki N, Kikuchi T, Murata A, Lee I, Yamada H, Inokuma H. (2009). Effects of mosapride on motility of the small intestine and caecum in normal horses after jejunocaecostomy. J Vet Sci, 10(2), 157-160. https://doi.org/10.4142/jvs.2009.10.2.157

Publication

Journal of veterinary science
ISSN: 1976-555X
NlmUniqueID: 100964185
Country: Korea (South)
Language: English
Volume: 10
Issue: 2
Pages: 157-160

Researcher Affiliations

Okamura, Kouichi
  • The United Graduate School of Veterinary Sciences, Gifu University, Gifu-shi, Japan.
Sasaki, Naoki
    Kikuchi, Takuya
      Murata, Aya
        Lee, Inhyung
          Yamada, Haruo
            Inokuma, Hisashi

              MeSH Terms

              • Anastomosis, Surgical / veterinary
              • Animals
              • Benzamides / pharmacology
              • Cecum / drug effects
              • Cecum / physiology
              • Electrophysiology
              • Female
              • Gastrointestinal Agents / pharmacology
              • Gastrointestinal Motility / drug effects
              • Horses / physiology
              • Horses / surgery
              • Intestine, Small / drug effects
              • Intestine, Small / physiology
              • Intestine, Small / surgery
              • Jejunostomy / veterinary
              • Male
              • Morpholines / pharmacology

              References

              This article includes 18 references
              1. Bauer AJ, Boeckxstaens GE. Mechanisms of postoperative ileus.. Neurogastroenterol Motil 2004 Oct;16 Suppl 2:54-60.
                pubmed: 15357852doi: 10.1111/j.1743-3150.2004.00558.xgoogle scholar: lookup
              2. Cohen ND, Lester GD, Sanchez LC, Merritt AM, Roussel AJ Jr. Evaluation of risk factors associated with development of postoperative ileus in horses.. J Am Vet Med Assoc 2004 Oct 1;225(7):1070-8.
                pubmed: 15515986doi: 10.2460/javma.2004.225.1070google scholar: lookup
              3. Dart AJ, Hodgson DR. Role of prokinetic drugs for treatment of postoperative ileus in the horse.. Aust Vet J 1998 Jan;76(1):25-31.
                pubmed: 9578763
              4. Donawick WJ, Christie BA, Stewart JV. Resection of diseased ileum in the horse.. J Am Vet Med Assoc 1971 Nov 1;159(9):1146-9.
                pubmed: 5165457
              5. Embertson RM, Colahan PT, Brown MP, Peyton LC, Schneider RK, Granstedt ME. Ileal impaction in the horse.. J Am Vet Med Assoc 1985 Mar 15;186(6):570-2.
                pubmed: 3988588
              6. Ford TS, Freeman DE, Ross MW, Richardson DW, Martin BB, Madison JB. Ileocecal intussusception in horses: 26 cases (1981-1988).. J Am Vet Med Assoc 1990 Jan 1;196(1):121-6.
                pubmed: 2295546
              7. Frankeny RL, Wilson DA, Messer NT 4th, Campbell-Beggs C. Jejunal intussusception: a complication of functional end-to-end stapled anastomoses in two ponies.. Vet Surg 1995 Nov-Dec;24(6):515-7.
                pubmed: 8560747doi: 10.1111/j.1532-950x.1995.tb01363.xgoogle scholar: lookup
              8. Freeman DE. Surgery of the small intestine.. Vet Clin North Am Equine Pract 1997 Aug;13(2):261-301.
                pubmed: 9290184doi: 10.1016/s0749-0739(17)30240-7google scholar: lookup
              9. Kajimoto T. [Relation between electrogastrography and gastric electromyogram, mechanical activity].. J Smooth Muscle Res 1995 Jun;31(3):93-107.
                pubmed: 8563060doi: 10.1540/jsmr.31.93google scholar: lookup
              10. Sasaki N, Lee I, Ayukawa Y, Yamada H. Clinical applications of electrointestinography in the horse. J Equine Sci 2004;15:85–92.
              11. Sasaki N, Mizuno Y, Yoshihara T. The application of electrocecography for evaluation of cecum motility in horses.. J Vet Med Sci 1998 Nov;60(11):1221-6.
                pubmed: 9853303doi: 10.1292/jvms.60.1221google scholar: lookup
              12. Sasaki N, Murata A, Lee I, Yamada H. Evaluation of equine cecal motility by ausculation, ultrasonography and electrointestinography after jejunocecostomy.. Res Vet Sci 2008 Apr;84(2):305-10.
                pubmed: 17570455doi: 10.1016/j.rvsc.2007.04.009google scholar: lookup
              13. Sasaki N, Okamura K, Yamada H. Effects of mosapride, a 5-hydroxytryptamine 4 receptor agonist, on electrical activity of the small intestine and cecum in horses.. Am J Vet Res 2005 Aug;66(8):1321-3.
                pubmed: 16173472doi: 10.2460/ajvr.2005.66.1321google scholar: lookup
              14. Smith CL, Dowling BA, Dart AJ. Recent advances in equine abdominal surgery.. Vet J 2005 Jul;170(1):41-51.
                pubmed: 15993788doi: 10.1016/j.tvjl.2004.03.019google scholar: lookup
              15. Van Hoogmoed LM, Nieto JE, Snyder JR, Harmon FA. Survey of prokinetic use in horses with gastrointestinal injury.. Vet Surg 2004 May-Jun;33(3):279-85.
                pubmed: 15104636doi: 10.1111/j.1532-950x.2004.04041.xgoogle scholar: lookup
              16. Weiss R, Abel D, Scholtysik G, Straub R, Mevissen M. 5-Hydroxytryptamine mediated contractions in isolated preparations of equine ileum and pelvic flexure: pharmacological characterization of a new 5-HT(4) agonist.. J Vet Pharmacol Ther 2002 Feb;25(1):49-58.
                pubmed: 11874527doi: 10.1046/j.1365-2885.2002.00380.xgoogle scholar: lookup
              17. Yoshida N, Ito T, Karasawa T, Itoh Z. AS-4370, a new gastrokinetic agent, enhances upper gastrointestinal motor activity in conscious dogs.. J Pharmacol Exp Ther 1991 May;257(2):781-7.
                pubmed: 2033519
              18. Yoshida N, Omoya H, Oka M, Furukawa K, Ito T, Karasawa T. AS-4370, a novel gastrokinetic agent free of dopamine D2 receptor antagonist properties.. Arch Int Pharmacodyn Ther 1989 Jul-Aug;300:51-67.
                pubmed: 2533479

              Citations

              This article has been cited 2 times.
              1. Laus F, Fratini M, Paggi E, Faillace V, Spaterna A, Tesei B, Fettucciari K, Bassotti G. Effects of Single-Dose Prucalopride on Intestinal Hypomotility in Horses: Preliminary Observations. Sci Rep 2017 Jan 27;7:41526.
                doi: 10.1038/srep41526pubmed: 28128322google scholar: lookup
              2. Munsterman AS, Dias Moreira AS, Kottwitz J. Evaluation of the Effects of Detomidine on Equine Myoelectrical Activity Using Electrointestinography. J Vet Emerg Crit Care (San Antonio) 2025 Mar-Apr;35(2):120-130.
                doi: 10.1111/vec.13464pubmed: 40254911google scholar: lookup
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