Omneity® Pellets
All-In-One Vitamin & Mineral Pellet
Effects of physical activity and other types of stress on catecholamine metabolism in various animal species.
Abstract: The investigation of catecholamine (CA) metabolism in animals subjected to various types of stress (different pain syndromes; cranial trauma; immobilization; cooling) and physical exercise shows considerable similarity among species in the sequence of changes, leading from the activation to the depletion of the sympathoadrenal system. The changes caused by physical exercise tend to be more pronounced in individuals with a genetic predisposition to greater stress responses. Stress adaption, induced by special training or by long-duration exposure to hypoxia, can substantially prevent the changes caused by physical exercise. Trained rats at rest show accelerated CA turnover, and after exercise, adaptive hypometabolic changes. Physical exercise causes both unspecific changes in CA metabolism, similar to those seen after other types of stress, and more specific ones, i.e., suppression of tissue CA synthesis and nonresponsiveness to exogenous L-tyrosine or L-DOPA. Adrenal CA synthesis could be restored in such animals by treatment with glucocorticoids and cyclic-AMP (c-AMP). The depression of CA synthesis after hard physical activity may be a mechanism for protecting the body from the injurious effect of the excessive CA release that would occur under stress.
Publication Date: 1984-01-01 PubMed ID: 6541242DOI: 10.1007/BF01254761Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Comparative Study
- Journal Article
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The study explores the impact of physical activity and various stressors on the metabolism of catecholamines (CAs, a type of hormone) in different animal species. The research findings indicate that there are notable similarities across species in how these influences activate and then deplete the body’s sympathoadrenal system, which produces CAs. Moreover, the study reveals that physical activity tends to have more significant effects in those genetically inclined to greater stress responses.
Catecholamine Metabolism and Stress
- The research revolves around catecholamine (CA), a group of hormones produced by the body in response to stress. These include key hormones like adrenaline (epinephrine) and noradrenaline (norepinephrine).
- The study took into account various forms of stress, such as different pain syndromes, cranial trauma, immobilization, and cooling, along with physical exercise. All of these stimuli activate the sympathoadrenal system, which controls the production and release of CAs.
- The evidence indicates that there’s a considerable similarity among animal species in the sequence of biochemical changes that occur from the activation to the depletion of this system. In other words, different types of stress and physical exercise share a common pathway in terms of their impact on the body’s hormonal response.
Greater Impact in Individuals with Higher Stress Responses
- Investigation reveals that individuals with a genetic predisposition to larger stress responses tend to exhibit more pronounced changes in CA metabolism due to physical activity.
- Thus, the study suggests that genetics can influence how the body’s hormone system responds both to exercise and stress.
Effects of Stress Adaptation
- The paper discusses how stress adaptation, induced by specific training or long-duration exposure to low-oxygen conditions (hypoxia), can notably prevent the changes in CA metabolism caused by physical exercise.
- For example, restful trained rats demonstrate increased CA turnover and, following exercise, exhibit adaptive hypometabolic changes. Such adaptations might protect the body from the potential harm associated with significant shifts in CA metabolism.
Specific Changes Caused by Physical Exercise
- Physical exercise not only causes generic changes in CA metabolism but also leads to more specific ones, such as the suppression of tissue CA synthesis and nonresponsiveness to L-tyrosine or L-DOPA (precursors to catecholamines).
- However, the study showed that in physically taxed animals, adrenal CA synthesis could be restored by treatment with glucocorticoids and cyclic-AMP (c-AMP), indicating potential therapeutic strategies for rebalancing CA production.
- The depression of CA synthesis observed after intense physical activity might work as a defense mechanism, protecting the body from the harmful effect of excessive CA release under stress.
Cite This Article
APA
Matlina E.
(1984).
Effects of physical activity and other types of stress on catecholamine metabolism in various animal species.
J Neural Transm, 60(1), 11-18.
https://doi.org/10.1007/BF01254761 Publication
Researcher Affiliations
MeSH Terms
- Adaptation, Physiological
- Adrenal Medulla / metabolism
- Animals
- Brain / metabolism
- Catecholamines / blood
- Catecholamines / metabolism
- Catecholamines / urine
- Disease Susceptibility
- Fatigue / physiopathology
- Guinea Pigs
- Horses
- Humans
- Hypoxia / physiopathology
- Physical Exertion
- Rats
- Rats, Inbred Strains
- Stress, Physiological / metabolism
- Stress, Psychological / metabolism
References
This article includes 19 references
- Malysheva VA, Matlina ESh. [Catecholamine metabolism in rats after muscular exertion].. Probl Endokrinol (Mosk) 1971 Nov-Dec;17(6):84-9.
- Matlina ESh, Bobylev IF, Skorupski K, Pukhova GS. [Correlations between the indices of the state of the sympathetic-adrenal and of the hypophyseal-adrenal systems and the level of insulin in horses under various exposures].. Biull Eksp Biol Med 1980 Feb;89(2):131-4.
- Matlina EA, Vaĭsman SM, Bykhovskaia KM, Vasil'ev VN. [Mechanisms of catecholamine synthesis disorders in the adrenals of rats subjected to physical fatigue].. Biull Eksp Biol Med 1975 May;79(5):34-6.
- Matlina ESh, Vaĭsman SM, Zaĭdner IG, Kogan BM, Nozdracheva LV. [Effect of successive cooling and immobilization on catecholamine metabolism in rat tissues].. Fiziol Zh SSSR Im I M Sechenova 1974 Apr;60(4):540-7.
- Matlina ESh, Pukhova GS, Grafova VN, Kassil' GN, Kryshanovskii GN. [The effect of DOPA on catecholamine metabolism in spinal pain syndrome].. Vopr Med Khim 1973 Mar-Apr;19(2):173-6.
- Matlina ESh, Pukhova GS, Zutler AS. [The effect of tyrosine on catecholamine biosynthesis in intact rats].. Biull Eksp Biol Med 1973 Jun;75(6):33-5.
- Volina EV, Matlina ESh, Kurbanova GD. [Effect of prednisolone on 3H-catecholamine synthesis in the adrenals of physically fatigued rats].. Biull Eksp Biol Med 1980 Dec;90(12):688-90.
- Matlina ESh. [Catecholamine metabolism in the hormonal and mediator links of the sympathoadrenal system under stress].. Usp Fiziol Nauk 1972 Oct-Dec;3(4):92-130.
- Pukhova GS, Matlina ESh. [Effect of DOPA and tyrosine on catecholamine metabolism upon electric stimulation of the sciatic nerve in rats].. Fiziol Zh SSSR Im I M Sechenova 1972 Nov;58(11):1731-6.
- Kassil' GN, Kryzhanovskiĭ GN, Matlina ESh, Pukhova GS, Grafova VN. [Catecholamine metabolism in painful tetanus].. Dokl Akad Nauk SSSR 1972 May-Jun;204(1):246-9.
- Matlina ESh, Kassil' GN. [Catecholamine metabolism during physical exertion in man and animals].. Usp Fiziol Nauk 1976 Apr-May;7(2):13-42.
- Matlina ES, Pshennikova MG, Meerson EZ. [Effect of the duration and intensity of hypoxia on the adaptation of the sympathetic-adrenal system].. Patol Fiziol Eksp Ter 1977 Jul-Aug;(4):16-20.
- Matlina ESh, Kassil' GN, Shirinian EA. [Effect of DOPA on catecholamine metabolism in experimental crainocerebral injury].. Dokl Akad Nauk SSSR 1970;194(6):1458-60.
- Matlina ESh, Pukhova GS, Galimov SD, Almaeva SN, Galenchik AI. [Catecholamine metabolism during adaptation to muscular activity].. Fiziol Zh SSSR Im I M Sechenova 1976 Mar;62(3):431-7.
- Kvetnansky R, Mikulaj L. Adrenal and urinary catecholamines in rats during adaptation to repeated immobilization stress.. Endocrinology 1970 Oct;87(4):738-43.
- Matlina ESh, Zutler AS. [Effect of DOPA administration on catecholamine metabolism in rats during physical exertion (swimming)].. Probl Endokrinol (Mosk) 1973 Jan-Feb;19(1):80-4.
- Malysheva VA, Matlina ESh. [State of catecholamine synthesis during development of muscular fatigue].. Biull Eksp Biol Med 1973 Aug;76(8):53-6.
- Matlina ESh, Kassil' GN. [Effect of glucocorticolids on catecholamine synthesis in the heart and adrenals of rats in the presence of physical fatigue].. Biull Eksp Biol Med 1977 Jul;84(7):11-3.
- Wurtman RJ, Larin F, Mostafapour S, Fernstrom JD. Brain catechol synthesis: control by train tyrosine concentration.. Science 1974 Jul 12;185(4146):183-4.
Citations
This article has been cited 3 times.- Pagliari R, Peyrin L. Physical conditioning in rats influences the central and peripheral catecholamine responses to sustained exercise. Eur J Appl Physiol Occup Physiol 1995;71(1):41-52.
- Sulakhe SJ, Pulga VB, Tran S. Hepatic alpha 1 and beta adrenergic receptors in various animal species. Mol Cell Biochem 1988 Sep;83(1):81-8.
- Sagnol M, Claustre J, Cottet-Emard JM, Pequignot JM, Fellmann N, Coudert J, Peyrin L. Plasma free and sulphated catecholamines after ultra-long exercise and recovery. Eur J Appl Physiol Occup Physiol 1990;60(2):91-7.
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists
