Effects of topical administration of 1% brinzolamide on intraocular pressure in clinically normal horses.
Abstract: Only few drugs with limited efficacy are available for topical treatment of equine glaucoma. Objective: To evaluate the effect of topical administration of 1% brinzolamide on intraocular pressure (IOP) in clinically normal horses. Methods: Healthy mature horses (n = 20) with normal ocular findings, were studied. The IOP was measured 5 times daily (07.00, 11.00, 15.00, 19.00 and 23.00 h) over 10 days. On Days 1 and 2, baseline values were established. On Days 3-5 one eye of each horse was treated with one drop of 1% brinzolamide every 24 h immediately following the 07.00 h measurement. On Days 6-8 the same eye was treated with 1% brinzolamide every 12 h (07.00 and 19.00 h). Measurements on Days 9 and 10 documented the return of IOP to baseline values. Statistical analysis of the data was performed. Results: In the treated eye a significant decrease in IOP compared to baseline values was noted during both the 24 and 12 h dosing periods (P < 0.001). During the once-daily treatment protocol an IOP reduction of 3.1 +/- 13 mmHg (14%) from baseline was recorded. During the twice-daily protocol a total IOP reduction of 5.0 +/- 1.5 mmHg (21%) was achieved. Conclusions: Intraocular pressure was significantly decreased by 1% brinzolamide in a once-daily and a twice-daily treatment protocol in normotensive eyes. These findings suggest that brinzolamide might also be effective in horses with an elevated IOP. Conclusions: This drug may be useful for treatment of equine glaucoma.
Publication Date: 2008-05-20 PubMed ID: 18487097DOI: 10.2746/042516408X297426Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The study investigates the effect of 1% brinzolamide eye drops on intraocular pressure in horses, suggesting it may be an effective treatment option for equine glaucoma due to its significant success in reducing pressure levels.
Objective and Methodology
- The objective of this research was to assess the effect of topical administration of 1% brinzolamide on intraocular pressure (IOP) in clinically normal horses. This was geared towards discovering potential treatment options for equine glaucoma, a condition that has limited effective therapies available.
- To conduct this research, 20 healthy, mature horses with normal ocular findings were used in the study. Their intraocular pressure was measured five times a day over a ten-day period.
- Baseline measurements were taken on the first and second day. For the next three days, one eye of each horse was treated with a drop of 1% brinzolamide immediately after the 07.00 h measurement. For the following three days, the same eye was treated with 1% brinzolamide every 12 hours. Measurement on Day 9 and 10 documented the return of IOP to baseline values.
Results
- The results demonstrated that there was a significant decrease in IOP in the treated eye. This was valid for both the 24 hour and 12 hour dosing periods.
- During the once-daily treatment protocol, an IOP reduction of 3.1 +/- 13 mmHg, or 14% from baseline was recorded. During the twice-daily protocol, a total IOP reduction of 5.0 +/- 1.5 mmHg, or 21%, was achieved.
Conclusion
- The study concluded that intraocular pressure was notably decreased by 1% brinzolamide under both a once-daily and twice-daily treatment protocol in normotensive eyes. This suggests that brinzolamide might be effective in horses with elevated IOP.
- These findings imply that brinzolamide might be a potential therapeutic agent for equine glaucoma, potentially filling a gap in effective treatment options for this condition in horses.
Cite This Article
APA
Germann SE, Matheis FL, Rampazzo A, Burger D, Roos M, Spiess BM.
(2008).
Effects of topical administration of 1% brinzolamide on intraocular pressure in clinically normal horses.
Equine Vet J, 40(7), 662-665.
https://doi.org/10.2746/042516408X297426 Publication
Researcher Affiliations
- Ophthalmology Section, Equine Department Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland.
MeSH Terms
- Administration, Topical
- Animals
- Carbonic Anhydrase Inhibitors / administration & dosage
- Carbonic Anhydrase Inhibitors / adverse effects
- Carbonic Anhydrase Inhibitors / pharmacology
- Dose-Response Relationship, Drug
- Drug Administration Schedule / veterinary
- Female
- Glaucoma / drug therapy
- Glaucoma / veterinary
- Horse Diseases / drug therapy
- Horses
- Intraocular Pressure / drug effects
- Male
- Ophthalmic Solutions / administration & dosage
- Ophthalmic Solutions / adverse effects
- Reference Values
- Sulfonamides / administration & dosage
- Sulfonamides / adverse effects
- Sulfonamides / pharmacology
- Thiazines / administration & dosage
- Thiazines / adverse effects
- Thiazines / pharmacology
Citations
This article has been cited 2 times.- Tucker-Retter EK, Yamagata M, Gilger B, Oh A. Retrospective Assessment of Carbonic Anhydrase Inhibitors in Topical or Episcleral Implant Form for the Treatment of Equine Glaucoma. Vet Ophthalmol 2025 Nov;28(6):977-982.
- Von Zup M, Lassaline M, Kass PH, Miller PE, Thomasy SM. Effects of 0.2% brimonidine and 0.2% brimonidine-0.5% timolol on intraocular pressure and pupil size in normal equine eyes. Equine Vet J 2017 Nov;49(6):810-814.
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists
