Environmental risk factors for UV-induced cutaneous neoplasia in horses: A GIS approach.
Abstract: Ultraviolet light (UV) is a risk factor for the development of cutaneous neoplasia in many mammalian species. This study evaluated UV exposure as a risk factor of concern for the development of cutaneous neoplasia in equine species due to the significant UV exposure that may accrue over their lifetimes. Neoplastic biopsy specimens from 3272 horses that were submitted over a 10-year period to the Colorado State University Diagnostic Medicine Center and to the University of Saskatchewan Western College of Veterinary Medicine and Prairie Diagnostic Services were evaluated. This retrospective study assessed the spatial relationships between altitude, latitude, longitude, and UV maximum value and the probability of UV-induced cutaneous neoplasia. Cases from areas at high altitude proved to have a higher prevalence of UV-induced cutaneous neoplasia than those from areas at lower elevations. A multivariable regression analysis demonstrated that altitude was the only factor significantly and positively associated with the diagnosis of UV-induced neoplasia. Evidence of cutaneous neoplasia in horses and environmental factors that influence the degree of UV exposure in a geographic location may aid in diagnosis and suggest preventive measures from UV overexposure. Facteurs de risque environnementaux des néoplasies cutanées induites par les UV chez le cheval : une approche SIG. La lumière ultraviolette (UV) est un facteur de risque pour le développement de néoplasies cutanées chez de nombreuses espèces de mammifères. Cette étude a évalué l’exposition aux UV en tant que facteur de risque préoccupant pour le développement de néoplasies cutanées chez les équidés en raison de l’exposition importante aux UV qui peut s’accumuler au cours de leur vie. Des échantillons de biopsie néoplasique de 3272 chevaux qui ont été soumis sur une période de 10 ans au et au ont été évalués. Cette étude rétrospective a évalué les relations spatiales entre l’altitude, la latitude, la longitude et la valeur maximale des UV et la probabilité de néoplasie cutanée induite par les UV. Les cas des régions de haute altitude se sont avérés avoir une prévalence plus élevée de néoplasie cutanée induite par les UV que ceux des régions de basse altitude. Une analyse de régression multivariée a démontré que l’altitude était le seul facteur significativement et positivement associé au diagnostic de néoplasie induite par les UV. Les preuves de néoplasie cutanée chez les chevaux et les facteurs environnementaux qui influencent le degré d’exposition aux UV dans un lieu géographique peuvent aider au diagnostic et suggérer des mesures préventives contre la surexposition aux UV.(Traduit par D Serge Messier).
Copyright and/or publishing rights held by the Canadian Veterinary Medical Association.
Publication Date: 2023-10-02 PubMed ID: 37780476PubMed Central: PMC10506358
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- Journal Article
Summary
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This study investigates the role of ultraviolet (UV) exposure as a potential factor causing skin cancer (cutaneous neoplasia) in horses, finding a clear relationship between higher altitudes and a higher incidence of UV-induced skin cancer.
Research Objective
- The main objective of this study was to evaluate the effect of UV exposure on horses and whether such exposure contributes to the development of skin cancer. In particular, the study aimed to assess the relationship between altitude, latitude, longitude, and maximum UV value, and the probability of UV-induced skin cancer in horses.
Methodology
- Data was gathered from neoplastic biopsy specimens from 3,272 horses over a ten-year period. These samples were submitted to both the Colorado State University Diagnostic Medicine Center and the University of Saskatchewan Western College of Veterinary Medicine and Prairie Diagnostic Services.
- This was a retrospective study, meaning it used past data to analyze the correlation between various geographic and environmental factors and the incidence of cutaneous neoplasia in horses.
Findings
- Results from the study revealed that horses living in areas at high altitudes had a higher prevalence of skin cancer caused by UV exposure compared to those residing in areas at lower elevations.
- A multivariable regression analysis disclosed that altitude was the only variable significantly and positively associated with a diagnosis of UV-induced skin cancer. This suggests that higher elevation levels, which result in more intense UV exposure, result in a higher risk for developing skin cancer in horses.
Implications
- The study’s findings highlight the significance of environmental factors, such as altitude, in influencing the risk of UV-induced skin cancer in horses.
- Understanding these factors can aid veterinarians and horse owners in the early detection of skin cancer. Furthermore, it suggests potential preventative measures for horses living in areas with high UV exposure, such as sun protection treatments or limiting exposure during peak UV times.
Cite This Article
APA
Ramirez M, Duncan C, Schaffer PA, Wobeser B, Magzamen S.
(2023).
Environmental risk factors for UV-induced cutaneous neoplasia in horses: A GIS approach.
Can Vet J, 64(10), 971-975.
Publication
Researcher Affiliations
- Department of Environmental and Radiological Health Sciences (Ramirez, Magzamen) and Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences (Duncan, Schaffer), Colorado State University, 1681 Campus Delivery, Fort Collins, Colorado 80523, USA; Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4 (Wobeser).
- Department of Environmental and Radiological Health Sciences (Ramirez, Magzamen) and Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences (Duncan, Schaffer), Colorado State University, 1681 Campus Delivery, Fort Collins, Colorado 80523, USA; Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4 (Wobeser).
- Department of Environmental and Radiological Health Sciences (Ramirez, Magzamen) and Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences (Duncan, Schaffer), Colorado State University, 1681 Campus Delivery, Fort Collins, Colorado 80523, USA; Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4 (Wobeser).
- Department of Environmental and Radiological Health Sciences (Ramirez, Magzamen) and Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences (Duncan, Schaffer), Colorado State University, 1681 Campus Delivery, Fort Collins, Colorado 80523, USA; Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4 (Wobeser).
- Department of Environmental and Radiological Health Sciences (Ramirez, Magzamen) and Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences (Duncan, Schaffer), Colorado State University, 1681 Campus Delivery, Fort Collins, Colorado 80523, USA; Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4 (Wobeser).
MeSH Terms
- Humans
- Horses
- Animals
- Ultraviolet Rays / adverse effects
- Geographic Information Systems
- Retrospective Studies
- Skin Neoplasms / epidemiology
- Skin Neoplasms / etiology
- Skin Neoplasms / veterinary
- Risk Factors
- Mammals
- Horse Diseases / epidemiology
- Horse Diseases / etiology
- Horse Diseases / diagnosis
References
This article includes 18 references
- Narayanan DL, Saladi RN, Fox JL. Ultraviolet radiation and skin cancer.. Int J Dermatol 2010;49:978–986.
- Seidl-Philipp M, Frischhut N, Höllweger N, Schmuth M, Nguyen VA. Known and new facts on basal cell carcinoma.. J Dtsch Dermatol Ges 2021;19:1021–1041.
- Kaundinya T, Kundu RV, Feinglass J. The epidemiology of skin cancer by UV index: Cross-sectional analysis from the 2019 behavioral risk factor surveillance survey.. Arch Derm Res 2022;315:613–615.
- Moehrle M. Outdoor sports and skin cancer.. Clin Dermatol 2008;26:12–15.
- Henriksen K, Stamnes K, Volden G, Falk ES. Ultraviolet radiation at high latitudes and the risk of skin cancer.. Photodermatol 1989;6:110–117.
- Aceituno-Madera P, Buendía-Eisman A, Olmo FJ, Jiménez-Moleón JJ, Serrano-Ortega S. Melanoma, altitude, and UV-B radiation [article in Spanish]. Actas Dermosifiliogr 2011;102:199–205.
- Miura K, Olsen CM, Rea S, Marsden J, Green AC. Do airline pilots and cabin crew have raised risks of melanoma and other skin cancers? Systematic review and meta-analysis.. Br J Dermatol 2019;181:55–64.
- Parker ER. The influence of climate change on skin cancer incidence: A review of the evidence.. Int J Womens Dermatol 2021;7:17–27.
- Hiatt RA, Beyeler N. Cancer and climate change.. Lancet Oncol 2020;21:519–527.
- Gross TL, Ihrke PJ, Walder EJ, Affolter VK. Skin Diseases of the Dog and Cat: Clinical and Histopathologic Diagnosis.. 2nd ed. Oxford, United Kingdom: Blackwell Science; 2005.
- Hargis AM, Ihrke PJ, Spangler WL, Stannard AA. A retrospective clinicopathologic study of 212 dogs with cutaneous hemangiomas and hemangiosarcomas.. Vet Pathol 1992;29:316–328.
- Heeney JL, Valli VE. Bovine ocular squamous cell carcinoma: An epidemiological perspective.. Can J Comp Med 1985;49:21–26.
- Kopecky KE, Pugh GW, Hughes DE, Booth GD, Cheville NF. Biological effect of ultraviolet radiation on cattle: Bovine ocular squamous cell carcinoma.. Am J Vet Res 1979;40:1783–1788.
- Hewes CA, Sullins KE. Review of the treatment of equine cutaneous neoplasia.. American Association of Equine Practitioners Proceedings 2009 55:386–393.
- Jones SE. Papillomavirus in equids: A decade of discovery and more to come?. Equine Vet Educ 2022;34:236–240.
- Taylor S, Haldorson G. A review of equine sarcoid.. Equine Vet Educ 2013;25:210–216.
- Schaffer PA, Wobeser B, Martin LER, Dennis MM, Duncan CG. Cutaneous neoplastic lesions of equids in the central United States and Canada: 3,351 biopsy specimens from 3,272 equids (2000–2010). J Am Vet Med Assoc 2013;242:99–104.
- Schaffer PA, Wobeser B, Dennis MM, Duncan CG. Non-neoplastic lesions of equine skin in the central United States and Canada: A retrospective study.. Can Vet J 2013;54:262–266.
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