Equine acquired multiple acyl-CoA dehydrogenase deficiency (MADD) in 14 horses associated with ingestion of Maple leaves (Acer pseudoplatanus) covered with European tar spot (Rhytisma acerinum).

This research investigates a case where fourteen horses were suspected to have equine acquired multiple acyl-CoA dehydrogenase deficiency (MADD) after they had access to maple tree leaves (Acer pseudoplatanus) that were covered with a fungus known as European tar spot (Rhytisma acerinum). Through biochemical tests involving organic acids, glycine conjugates, and acylcarnitines in the urine, seven of these cases were confirmed.

Significance of the Study

• This research provides valuable insights about a potential health hazard for horses – the ingestion of Maple tree leaves covered with the European tar spot fungus.
• This research could be instrumental in preventing and treating this potentially fatal illness (MADD) in horses.

About Equine Acquired Multiple Acyl-CoA Dehydrogenase Deficiency (MADD)

• MADD, also known as atypical myopathy, is a severe metabolic disorder that can occur in horses.
• Equine MADD is characterized by muscle damage and weakness, and can be potentially fatal if not diagnosed early.

The Role of Maple Leaves and European Tar Spot Fungus

• The research highlights that the ingestion of certain Maple tree leaves covered with the European tar spot fungus may contribute to the development of MADD in horses.
• The fungal infection could possibly influence the toxicity of the leaves and therefore make them potentially harmful to horses.

Methodology and Diagnosis

• The scientific team applied biochemical data analyses relating to the level of specific organic acids, glycine conjugates, and acylcarnitines in the horse urine samples.
• Analysing these compounds in the urine proved to be an effective method for diagnosing horses with MADD.
• This methodology was considered the ‘gold standard’ for detecting this disease.

Key Findings

• Of the fourteen horses that were suspected to have MADD due to exposure to the infected Maple leaves, seven were confirmed through the biochemical testing methodology.
• The correlation between the ingestion of the fungus-infected leaves and the development of MADD represents a significant finding that could serve to increase awareness and preventative measures for horse owners.