Equine conjunctival pseudotumors.
Abstract: Five horses presented with unilateral pink, smooth, nonulcerated conjunctival masses with histologic features characteristic of inflammatory pseudotumors, i.e. proliferative inflammatory lesions clinically resembling true neoplasia. Although causes for the inflammatory lesions were not determined, based on the presence histologically of mononuclear (predominantly lymphocytic) inflammatory cell infiltrates and the absence of infectious agents, parasites or foreign bodies, an immune-mediated pathogenesis was suspected. Affected horses ranged from 5 to 8 years of age with no apparent breed or sex predilection. Conjunctival lesions were nodular in two cases and relatively flat and more diffuse in three cases. Third eyelid lesions were present in three cases and two affected eyes had corneal involvement. Based on findings from these five cases, the prognosis for equine conjunctival pseudotumors appears to be good when lesions are treated by partial or complete surgical excision, local administration of anti-inflammatory agents, or a combination of surgery and anti-inflammatory therapy.
Publication Date: 2001-06-09 PubMed ID: 11397284DOI: 10.1046/j.1463-5224.2000.00135.xGoogle Scholar: Lookup
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- Journal Article
Summary
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This study explores the cases of five horses that developed smooth pink non-ulcerated conjunctival masses, resembling tumors but actually identified as inflammatory lesions. Possible causes, treatment options, and prognosis for this condition, termed as ‘equine conjunctival pseudotumors’, were investigated.
Research Participants and Findings
- The subjects of this study were five horses aged between 5 and 8 years which presented with unilateral pink, smooth, and nonulcerated conjunctival masses.
- These purported tumors, upon histologic examination, were found to be inflammatory lesions resembling true neoplasms, leading to their categorization as “pseudotumors”.
- There was no discernible preference for these pseudotumors regarding the breed or sex of horses.
- The study found that the conjunctival lesions were nodular in two cases and relatively flat and more diffuse in three cases.
- It was also noted that in three cases, there were lesions in the third eyelid, and in two cases, the affected eyes also had corneal involvement.
Possible Causes and Treatment
- While causes for the inflammatory lesions were not definitively determined, researchers suspect an immune-mediated pathogenesis behind these pseudotumors.
- This suspicion is based on the histological presence of predominantly lymphocytic mononuclear inflammatory cell infiltrates. Furthermore, there was no evidence of infectious agents, parasites or foreign bodies, reinforcing the assumption of an immune-controlled cause.
- The study believes the prognosis for equine conjunctival pseudotumors is positive when the lesions are properly treated.
- Treatment options include partial or complete surgical excision, local administration of anti-inflammatory agents, or a combination of both therapy types.
In conclusion, this research raises awareness about the occurrence of equine conjunctival pseudotumors. By highlighting suitable treatment options and indicating a favorable prognosis, the study assists in better clinical course determination.
Cite This Article
APA
Moore CP, Grevan VL, Champagne ES, Collins BK, Collier LL.
(2001).
Equine conjunctival pseudotumors.
Vet Ophthalmol, 3(2-3), 57-63.
https://doi.org/10.1046/j.1463-5224.2000.00135.x Publication
Researcher Affiliations
- Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211; Northwest Animal Eye Specialists, 15615 Bel-Red Rd., Ste. D, Bellevue, WA 98008; Animal Eye Specialists, Waukesha, WI 53186; Animal Eye Care, 5603 W. Canal Drive, Kennewick, WA 99336.
Citations
This article has been cited 2 times.- Miglio A, Morelli C, Gialletti R, Lauteri E, Sforna M, Marenzoni ML, Antognoni MT. Clinical and immunophenotypic findings in 4 forms of equine lymphoma. Can Vet J 2019 Jan;60(1):33-40.
- Sypniewska A, Ziółkowska N. Nodular conjunctivitis as a novel ocular manifestation of canine sterile granuloma/pyogranuloma syndrome. BMC Vet Res 2026 Jan 19;22(1):96.
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