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Home / Equine Research Bank / Can Vet J / Equine herpesvirus 1 infection in mares vaccinated with a li...
The Canadian veterinary journal = La revue veterinaire canadienne1979; 20(5); 145-147;

Equine herpesvirus 1 infection in mares vaccinated with a live-virus rhinopneumonitis vaccine attenuated in cell culture.

Abstract: Vaccination, in July and again in either November or December 1976, of 55 pregnant Standardbred mares with a live-virus rhinopneumonitis vaccine attenuated in cell culture failed to protect some mares from infection with equine herpesvirus 1. From 1976-12-08 to 1977-03-08, 33 mares foaled healthy foals, 16 mares foaled dead foals or live foals which died usually within 48 hours and six mares aborted. Gross and histological examinations and virus isolation studies confirmed that equine herpesvirus 1 caused 18 of the 22 neonatal deaths, stillbirths or abortions.
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Publication Date: 1979-05-01 PubMed ID: 226261PubMed Central: PMC1789542
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

In a study conducted in 1976, 55 pregnant Standardbred mares were vaccinated against rhinopneumonitis. Despite vaccination, some mares still got infected with equine herpesvirus 1, leading to several neonatal deaths, stillbirths, and abortions.

Study Overview

  • 55 pregnant Standardbred mares were vaccinated in July and again in either November or December of 1976.
  • The vaccine used was a live-virus rhinopneumonitis vaccine that had been weakened in cell culture.

Outcomes

  • Between December 8, 1976, and March 8, 1977:
    • 33 mares gave birth to healthy foals.
    • 16 mares gave birth to dead foals or foals that died usually within 48 hours of birth.
    • 6 mares had abortions.
  • Through detailed examinations and virus isolation studies:
    • Equine herpesvirus 1 was identified as the cause of 18 out of the 22 cases of neonatal deaths, stillbirths, or abortions.

Conclusion

  • Despite vaccination against rhinopneumonitis, some mares were not protected from infection with equine herpesvirus 1.
  • This lack of protection resulted in a significant number of neonatal deaths, stillbirths, and abortions among the vaccinated mares.

Cite This Article

APA
Eaglesome MD, Henry JN, McKnight JD. (1979). Equine herpesvirus 1 infection in mares vaccinated with a live-virus rhinopneumonitis vaccine attenuated in cell culture. Can Vet J, 20(5), 145-147.

Publication

The Canadian veterinary journal = La revue veterinaire canadienne
ISSN: 0008-5286
NlmUniqueID: 0004653
Country: Canada
Language: English
Volume: 20
Issue: 5
Pages: 145-147

Researcher Affiliations

Eaglesome, M D
    Henry, J N
      McKnight, J D

        MeSH Terms

        • Animals
        • Female
        • Herpesviridae / immunology
        • Herpesviridae Infections / immunology
        • Herpesviridae Infections / prevention & control
        • Herpesviridae Infections / veterinary
        • Herpesvirus 1, Equid / immunology
        • Horse Diseases / immunology
        • Horse Diseases / prevention & control
        • Horses
        • Pregnancy
        • Vaccines, Attenuated
        • Viral Vaccines

        References

        This article includes 5 references
        1. CORNER AH, MITCHELL D, MEADS EB. Equine virus abortion in Canada. I. Pathological studies on aborted fetuses.. Cornell Vet 1963 Jan;53:78-88.
          pubmed: 14023067
        2. Bryans JT. On immunity to disease caused by equine herpesvirus 1.. J Am Vet Med Assoc 1969 Jul 15;155(2):294-300.
          pubmed: 4307796
        3. DOLL ER. Immunization against viral rhinopneumonitis of horses with live virus propagated in hamsters.. J Am Vet Med Assoc 1961 Dec 15;139:1324-30.
          pubmed: 13887043
        4. DOLL ER, BRYANS JT. Epizootiology of equine viral rhinopneumonitis.. J Am Vet Med Assoc 1963 Jan 1;142:31-7.
          pubmed: 14028462
        5. Jackson T, Kendrick JW. Paralysis of horses associated with equine herpesvirus 1 infection.. J Am Vet Med Assoc 1971 Apr 15;158(8):1351-7.
          pubmed: 4328999

        Citations

        This article has been cited 1 times.
        1. Corbeil LB. Criteria for development of animal models of diseases of the reproductive system. Am J Pathol 1980 Dec;101(3 Suppl):S241-53.
          pubmed: 6893900
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