FREE SHIPPING over $40
OVER 9000 FIVE-STAR REVIEWS
5% OFF ALL SUBSCRIPTIONS
100% HAPPINESS GUARANTEE
Analyze Diet
0
Home / Equine Research Bank / Vet Res Commun / Equine postanaesthetic myositis: thromboxanes, prostacyclin ...
Veterinary research communications1988; 12(2-3); 219-226; doi: 10.1007/BF00362803

Equine postanaesthetic myositis: thromboxanes, prostacyclin and prostaglandin E2 production.

Abstract: Arachidonic acid cyclooxygenase metabolites, thromboxane B2 (TXB2), prostaglandin E2 (PGE2) and 6-keto-prostaglandin F1 (6-keto-PGF1) were measured in horses where anaesthesia was maintained with halothane. Two horses suffering from postanaesthetic myositis were compared with four normal horses. TXB2 and PGE2 levels were higher in mixed venous blood drawn from the myopathic horses. An increase of TXB2 and PGE2 levels appeared when myopathic horses were rolled into dorsal recumbency after a prolonged period of lateral recumbency. One hour after the end of anaesthesia, TXB2 had continued to increase whereas PGE2 decreased. By measurements on blood samples drawn from the brachial vein, we have shown that the rising level of TXB2 in mixed venous blood is mainly due to the increase of TXB2 in blood draining the dependent leg. The origin of the rise in PGE2 is not demonstrated in this study. 6-keto-PGF1 did not change during anaesthesia. An explanation of this imbalance between TXB2 and 6-keto-PGF1 production is considered.
Get Full Text
Publication Date: 1988-01-01 PubMed ID: 3188388DOI: 10.1007/BF00362803Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
LinkedInCopy
  • Comparative Study
  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research investigates the correlation between the production levels of certain arachidonic acid cyclooxygenase metabolites and postanaesthetic myositis in horses. Notably, it shows an increase in thromboxane B2 (TXB2) and prostaglandin E2 (PGE2) in myopathic horses after anaesthesia, but no significant change in 6-keto-prostaglandin F1 (6-keto-PGF1).

Investigation of Arachidonic Acid Cyclooxygenase Metabolites

  • Reseachers measured the levels of cyclooxygenase metabolites: thromboxane B2 (TXB2), prostaglandin E2 (PGE2), and 6-keto-prostaglandin F1 (6-keto-PGF1) in horses that underwent anaesthesia with halothane.
  • Two groups of horses were compared in the study: one group of two horses suffering from postanaesthetic myositis and a control group of four healthy horses.
  • These metabolites were investigated due to their potential role in the inflammatory response following anaesthetic application.

Results Based on Animal Posture and Metabolite Levels

  • TXB2 and PGE2 levels were found to be higher in the blood of the horses suffering from postanaesthetic myositis compared to the healthy ones.
  • The researchers also noted a significant increase in TXB2 and PGE2 levels when these myopathic horses were moved from a lateral recumbent position (lying on their side) to a dorsal recumbent position (lying on their back).
  • In addition, TXB2 levels continued to increase after the anaesthesia ended, while PGE2 level decreased.
  • The researchers claimed that the increase of TXB2 level in mixed venous blood was mainly due to the rise of TXB2 in the blood from the dependent leg, observed from brachial vein blood samples.

6-keto-PGF1 Metabolite and Areas not Addressed

  • Despite changes in TXB2 and PGE2, the study found no significant alterations in 6-keto-PGF1 levels during anaesthesia, indicating a potential imbalance between the production of TXB2 and 6-keto-PGF1.
  • The study did not provide a clear explanation for the rising PGE2 levels, suggesting a need for further exploration in future research.

Cite This Article

APA
Serteyn D, Deby-Dupont G, Pincemail J, Mottart E, Philippart C, Lamy M. (1988). Equine postanaesthetic myositis: thromboxanes, prostacyclin and prostaglandin E2 production. Vet Res Commun, 12(2-3), 219-226. https://doi.org/10.1007/BF00362803

Publication

Veterinary research communications
ISSN: 0165-7380
NlmUniqueID: 8100520
Country: Switzerland
Language: English
Volume: 12
Issue: 2-3
Pages: 219-226

Researcher Affiliations

Serteyn, D
  • Service de Chirurgie, Faculté de Médecine Vétérinaire Ulg, Bruxelles.
Deby-Dupont, G
    Pincemail, J
      Mottart, E
        Philippart, C
          Lamy, M

            MeSH Terms

            • 6-Ketoprostaglandin F1 alpha / biosynthesis
            • 6-Ketoprostaglandin F1 alpha / blood
            • Anesthesia, General / adverse effects
            • Anesthesia, General / veterinary
            • Animals
            • Dinoprostone / biosynthesis
            • Dinoprostone / blood
            • Halothane
            • Horse Diseases / blood
            • Horse Diseases / etiology
            • Horses
            • Myositis / blood
            • Myositis / etiology
            • Myositis / veterinary
            • Prostaglandins / biosynthesis
            • Prostaglandins / blood
            • Thromboxane B2 / biosynthesis
            • Thromboxane B2 / blood

            References

            This article includes 22 references
            1. Faymonville ME, Deby-Dupont G, Larbuisson R, Deby C, Bodson L, Limet R, Lamy M. Prostaglandin E2, prostacyclin, and thromboxane changes during nonpulsatile cardiopulmonary bypass in humans.. J Thorac Cardiovasc Surg 1986 Jun;91(6):858-66.
              pubmed: 3520158
            2. Serteyn D, Mottart E, Michaux C, Micheels J, Philippart C, Lavergne L, Guillon C, Lamy M. Laser Doppler flowmetry: muscular microcirculation in anaesthetized horses.. Equine Vet J 1986 Sep;18(5):391-5.
              pubmed: 2945716doi: 10.1111/j.2042-3306.1986.tb03663.xgoogle scholar: lookup
            3. Flower RJ. Drugs which inhibit prostaglandin biosynthesis.. Pharmacol Rev 1974 Mar;26(1):33-67.
              pubmed: 4208101
            4. Cook HW, Lands WE. Mechanism for suppression of cellular biosynthesis of prostaglandins.. Nature 1976 Apr 15;260(5552):630-2.
              pubmed: 817209doi: 10.1038/260630a0google scholar: lookup
            5. Trim CM, Mason J. Post-anaesthetic forelimb lameness in horses.. Equine Vet J 1973 Apr;5(2):71-6.
              pubmed: 4791734doi: 10.1111/j.2042-3306.1973.tb03197.xgoogle scholar: lookup
            6. Serteyn D, Lavergne L, Coppens P, Mottart E, Philippart C, Micheels M, Lamy M. Equine post anaesthetic myositis: muscular post ischaemic hyperaemia measured by laser Doppler flowmetry.. Vet Rec 1988 Jul 30;123(5):126-8.
              pubmed: 2970713doi: 10.1136/vr.123.5.126google scholar: lookup
            7. Ferreira SH, Vane JR. Prostaglandins: their disappearance from and release into the circulation.. Nature 1967 Dec 2;216(5118):868-73.
              pubmed: 6074965doi: 10.1038/216868a0google scholar: lookup
            8. Granström E, Kindahl H. Radioimmunoassay of prostaglandins and thromboxanes.. Adv Prostaglandin Thromboxane Res 1978;5:119-210.
              pubmed: 727045
            9. White NA, Suarez M. Change in triceps muscle intracompartmental pressure with repositioning and padding of the lowermost thoracic limb of the horse.. Am J Vet Res 1986 Oct;47(10):2257-60.
              pubmed: 3777652
            10. Bourgain RH, Deby C, Deby-Dupont G, Andries R. Enhancement of arterial thromboformation by uric acid, a free radical scavenger.. Biochem Pharmacol 1982 Sep 15;31(18):3011-3.
              pubmed: 6814452doi: 10.1016/0006-2952(82)90281-7google scholar: lookup
            11. Hochachka PW. Defense strategies against hypoxia and hypothermia.. Science 1986 Jan 17;231(4735):234-41.
              pubmed: 2417316doi: 10.1126/science.2417316google scholar: lookup
            12. Deby C, Deby-Dupont G, Noël FX, Lavergne L. In vitro and in vivo arachidonic acid conversions into biologically active derivatives are enhanced by uric acid.. Biochem Pharmacol 1981 Aug 15;30(16):2243-9.
              pubmed: 6794572doi: 10.1016/0006-2952(81)90094-0google scholar: lookup
            13. Friend SC. Postanesthetic myonecrosis in horses.. Can Vet J 1981 Dec;22(12):367-71.
              pubmed: 7337914
            14. Nolan RD, Dusting GJ, Martin TJ. Phospholipase inhibition and the mechanism of angiotensin-induced prostacyclin release from rat mesenteric vasculature.. Biochem Pharmacol 1981 Aug 1;30(15):2121-5.
              pubmed: 7028038doi: 10.1016/0006-2952(81)90231-8google scholar: lookup
            15. Deby-Dupont G, Braun M, Lamy M, Deby C, Pincemail J, Faymonville ME, Damas P, Bodson L, Lecart MP, Goutier R. Thromboxane and prostacyclin release in adult respiratory distress syndrome.. Intensive Care Med 1987;13(3):167-74.
              pubmed: 3584647doi: 10.1007/BF00254700google scholar: lookup
            16. Moncada S, Gryglewski RJ, Bunting S, Vane JR. A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevents platelet aggregation.. Prostaglandins 1976 Nov;12(5):715-37.
              pubmed: 824686doi: 10.1016/0090-6980(76)90048-4google scholar: lookup
            17. Brown CM, Holmes JR. Haemodynamics in the horse: 2. Intracardiac, pulmonary arterial and aortic pressures.. Equine Vet J 1978 Oct;10(4):207-15.
              pubmed: 738261doi: 10.1111/j.2042-3306.1978.tb02263.xgoogle scholar: lookup
            18. Saugstad OD, Bo G, Ostrem T, Aasen AO. Hypoxanthine levels of plasma during hypoxemia in dogs.. Eur Surg Res 1977;9(1):23-33.
              pubmed: 14834doi: 10.1159/000127922google scholar: lookup
            19. Serteyn D, Lavergne L, Mottart E, Philippart C, Lamy M. [Equine postanesthetic myopathy: production of lactates by the compressed muscles in the horse anesthetized by halothane].. Schweiz Arch Tierheilkd 1987 Jan;129(1):19-22.
              pubmed: 3823829
            20. Lindsay WA, McDonell W, Bignell W. Equine postanesthetic forelimb lameness: intracompartmental muscle pressure changes and biochemical patterns.. Am J Vet Res 1980 Dec;41(12):1919-24.
              pubmed: 7212425
            21. Vargaftig BB, Chignard M, Benveniste J. Present concepts on the mechanisms of platelet aggregation.. Biochem Pharmacol 1981 Feb 15;30(4):263-71.
              pubmed: 7011325doi: 10.1016/0006-2952(81)90052-6google scholar: lookup
            22. Piper PJ, Vane JR, Wyllie JH. Inactivation of prostaglandins by the lungs.. Nature 1970 Feb 14;225(5233):600-4.
              pubmed: 4983971doi: 10.1038/225600a0google scholar: lookup

            Citations

            This article has been cited 5 times.
            1. Sanchez C, Horcajada MN, Membrez Scalfo F, Ameye L, Offord E, Henrotin Y. Carnosol Inhibits Pro-Inflammatory and Catabolic Mediators of Cartilage Breakdown in Human Osteoarthritic Chondrocytes and Mediates Cross-Talk between Subchondral Bone Osteoblasts and Chondrocytes. PLoS One 2015;10(8):e0136118.
              doi: 10.1371/journal.pone.0136118pubmed: 26292290google scholar: lookup
            2. Mathy-Hartert M, Jacquemond-Collet I, Priem F, Sanchez C, Lambert C, Henrotin Y. Curcumin inhibits pro-inflammatory mediators and metalloproteinase-3 production by chondrocytes. Inflamm Res 2009 Dec;58(12):899-908.
              doi: 10.1007/s00011-009-0063-1pubmed: 19579007google scholar: lookup
            3. Henrotin YE, Labasse AH, Jaspar JM, De Groote DD, Zheng SX, Guillou GB, Reginster JY. Effects of three avocado/soybean unsaponifiable mixtures on metalloproteinases, cytokines and prostaglandin E2 production by human articular chondrocytes. Clin Rheumatol 1998;17(1):31-9.
              doi: 10.1007/BF01450955pubmed: 9586676google scholar: lookup
            4. Bassleer C, Henrotin Y, Franchimont P. Effects of sodium naproxen on differentiated human chondrocytes cultivated in clusters. Clin Rheumatol 1992 Mar;11(1):60-5.
              doi: 10.1007/BF02207086pubmed: 1582121google scholar: lookup
            5. Herfs M, Herman L, Hubert P, Minner F, Arafa M, Roncarati P, Henrotin Y, Boniver J, Delvenne P. High expression of PGE2 enzymatic pathways in cervical (pre)neoplastic lesions and functional consequences for antigen-presenting cells. Cancer Immunol Immunother 2009 Apr;58(4):603-14.
              doi: 10.1007/s00262-008-0584-4pubmed: 18802697google scholar: lookup
            Subscribe to our newsletter
            Join 99,344 horse owners like you who receive our email updates on horse health and nutrition.