Equine rhinovirus serotypes 1 and 2: relationship to each other and to aphthoviruses and cardioviruses.
Abstract: Equine rhinoviruses (ERVs) are picornaviruses which cause a mild respiratory infection in horses. The illness resembles the common cold brought about by rhinoviruses in humans; however, the presence of a viraemia during ERV-1 infection, the occurrence of persistent infections and the physical properties are all more reminiscent of foot-and-mouth disease virus (FMDV). cDNA cloning and sequencing of the genomes of ERV-1 and ERV-2 between the poly(C) and poly(A) tracts showed that the serotypes are heterogeneous. Nevertheless, the genomic architecture of both serotypes is most similar to that of FMDV. Indeed, a comparison of the derived protein sequences of ERV-1 shows that their identity is greatest to FMDV. In contrast, most ERV-2 proteins are more related to encephalomyocarditis virus (EMCV) proteins than they are to FMDV or ERV-1. These results place ERV-1 alongside FMDV in the aphthovirus genus of the picornavirus family and indicate that this virus may serve as a model system for examining the biology of FMDV.
Publication Date: 1996-08-01 PubMed ID: 8760418DOI: 10.1099/0022-1317-77-8-1719Google Scholar: Lookup
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- Journal Article
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- Non-U.S. Gov't
Summary
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This research article explores the relationship between two types of equine rhinoviruses (ERV) which cause a common cold-like infection in horses, and other viruses in the picornavirus family including foot-and-mouth disease virus (FMDV) and encephalomyocarditis virus (EMCV). The study found that while both types of ERV have differences, ERV-1 is more genetically similar to FMDV, while most ERV-2 proteins are more related to EMCV.
Equine Rhinoviruses and Their Relation to Other Viruses
- The research focuses on equine rhinoviruses (ERV), which are part of the picornavirus family and cause a type of respiratory infection in horses similar to common cold in humans.
li>Despite their similarity to human rhinoviruses, the symptoms of ERV-1 infection, including inflammation, persistent infections, and certain physical properties, are more akin to foot-and-mouth disease virus (FMDV). - cDNA cloning and genome sequencing techniques were used in this study to understand the genetic structure of ERV-1 and ERV-2.
- The researchers found that the two types of ERV are not identical, showing heterogeneity between the serotypes.
Genomic Similarities and Differences
- Despite the differences, the overall genomic structure of both ERV-1 and ERV-2 is most similar to FMDV, sharing the most similarities with this aphthovirus genus member of the picornavirus family.
- However, a comparative analysis of derived protein sequences revealed that ERV-1 is more closely tied to FMDV while most ERV-2 proteins are more related to another virus, encephalomyocarditis virus (EMCV). This indicates a split in relation to these distinct viruses within the picornavirus family.
Implications and Future Research Directions
- The study concludes that the results place ERV-1 alongside with FMDV in the aphthovirus genus within the picornavirus family, highlighting a strong genetic relationship between the two.
- Additionally, because of its genetic similarity to FMDV, ERV-1 could potentially serve as a model system for studying the biology of foot-and-mouth disease virus, opening up new avenues of research in this field.
Cite This Article
APA
Wutz G, Auer H, Nowotny N, Grosse B, Skern T, Kuechler E.
(1996).
Equine rhinovirus serotypes 1 and 2: relationship to each other and to aphthoviruses and cardioviruses.
J Gen Virol, 77 ( Pt 8), 1719-1730.
https://doi.org/10.1099/0022-1317-77-8-1719 Publication
Researcher Affiliations
- Institute of Biochemistry, Medical Faculty, University of Vienna, Austria.
MeSH Terms
- Amino Acid Sequence
- Animals
- Aphthovirus / classification
- Aphthovirus / genetics
- Base Sequence
- Capsid / chemistry
- Cardiovirus / classification
- Cardiovirus / genetics
- Cell Line
- DNA, Viral
- Genome, Viral
- Humans
- Introns
- Molecular Sequence Data
- Picornaviridae / classification
- Picornaviridae / genetics
- Rabbits
- Sequence Homology, Amino Acid
- Serotyping
- Viral Proteins / genetics
Citations
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