Evaluation of intradermal mould antigen testing in the diagnosis of equine chronic obstructive pulmonary disease.
Abstract: Intradermal end-point titres for commercial aqueous extracts of Micropolyspora faeni, Thermoactinomyces vulgaris and Aspergillus fumigatus were determined in control and chronic obstructive pulmonary disease (COPD) affected horses. The intradermal end-point titres of control and COPD-affected horses were not significantly different and values for individual horses for M. faeni, A. fumigatus and T. vulgaris were not correlated with the pulmonary dysfunction or with the bronchoalveolar lavage fluid neutrophilia which had been induced by previous inhalation challenges with these antigens and by 'natural (hay and straw) challenges'. These findings suggest divergence of the dermal and pulmonary reactivities to M. faeni, A. fumigatus and T. vulgaris in the horse and indicate that intradermal mould antigen testing is of limited value in the investigation of equine COPD.
Publication Date: 1993-07-01 PubMed ID: 8354210DOI: 10.1111/j.2042-3306.1993.tb02962.xGoogle Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The research investigates the effectiveness of using intradermal mould antigen tests for the diagnosis of equine chronic obstructive pulmonary disease (COPD), concluding that it offers limited value due to the divergence of skin and lung reactions.
Overview of the Research
- The study focuses on the comparison of intradermal end-point titres, which are the highest dilutions of a solution that still effect a positive reaction, in horses affected and not affected with equine chronic obstructive pulmonary disease (COPD). The antigens examined were Micropolyspora faeni, Thermoactinomyces vulgaris, and Aspergillus fumigatus, all of which may be implicated in the disease.
- It provides no significant difference between intradermal titres in control and COPD-affected horses. Moreover, these titres for individual horses and specific antigens showed no correlation with the degree of lung dysfunction or with the increase in neutrophils found in lung fluid samples, which were caused by previous exposure to these antigens and natural triggers like hay and straw.
Divergence of Dermal and Pulmonary Reactivities
- The study indicates a discrepancy between the skin (dermal) and lung (pulmonary) reactions to the tested antigens in horses. The researchers suggest that skin test results do not accurately reflect the lung’s response to these antigens, as no corresponding relationship was found between skin tests and lung function markers.
- The divergence between these two responses suggests that each site might interact differently with the antigens, underlying the biological complexity of equine COPD.
Implication of the Research
- These findings suggest that intradermal mould antigen testing is of limited value in diagnosing or investigating equine COPD. As skin tests do not correlate with lung pathology in this study, it implies they might not be a reliable diagnostic tool.
- This has implications for veterinary practice and directs future research towards identifying more effective diagnostic tests for equine COPD.
Cite This Article
APA
McGorum BC, Dixon PM, Halliwell RE.
(1993).
Evaluation of intradermal mould antigen testing in the diagnosis of equine chronic obstructive pulmonary disease.
Equine Vet J, 25(4), 273-275.
https://doi.org/10.1111/j.2042-3306.1993.tb02962.x Publication
Researcher Affiliations
- Department of Veterinary Clinical Studies, Royal (Dick) School of Veterinary Studies, Roslin, Midlothian, UK.
MeSH Terms
- Animals
- Antigens, Fungal / administration & dosage
- Antigens, Fungal / immunology
- Aspergillus fumigatus / immunology
- Evaluation Studies as Topic
- Female
- Horse Diseases / diagnosis
- Horse Diseases / immunology
- Horses
- Injections, Intradermal / veterinary
- Intradermal Tests / veterinary
- Lung Diseases, Obstructive / diagnosis
- Lung Diseases, Obstructive / immunology
- Lung Diseases, Obstructive / veterinary
- Male
- Micromonosporaceae / immunology
Citations
This article has been cited 4 times.- Lo Feudo CM, Stucchi L, Alberti E, Conturba B, Zucca E, Ferrucci F. Intradermal Testing Results in Horses Affected by Mild-Moderate and Severe Equine Asthma.. Animals (Basel) 2021 Jul 13;11(7).
- Moran G, Buechner-Maxwell VA, Folch H, Henriquez C, Galecio JS, Perez B, Carrasco C, Barria M. Increased apoptosis of CD4 and CD8 T lymphocytes in the airways of horses with recurrent airway obstruction.. Vet Res Commun 2011 Oct;35(7):447-56.
- Morán G, Folch H, Araya O, Burgos R, Barria M. Detection of reaginic antibodies against Faenia rectivirgula from the serum of horses affected with Recurrent Airway Obstruction by an in vitro bioassay.. Vet Res Commun 2010 Dec;34(8):719-26.
- Morán G, Burgos R, Araya O, Folch H. In vitro bioassay to detect reaginic antibodies from the serum of horses affected with recurrent airway obstruction.. Vet Res Commun 2010 Jan;34(1):91-9.
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