Evaluation of urine sucrose concentration for detection of gastric ulcers in horses.
Abstract: To evaluate the use of sucrose permeability testing to detect ulcers in the gastric squamous mucosa of horses. Methods: 13 adult horses ranging from 5 to 19 years of age. Methods: Following induction of gastric ulcers by intermittent feed deprivation, horses underwent sucrose permeability testing (administration of sucrose by nasogastric intubation followed by collection of urine at 2 and 4 hours after intubation) and gastric endoscopy. Squamous ulcers were assigned a severity score (range, 0 to 3) by use of an established scoring system. Horses were subsequently administered omeprazole for 21 days, and sucrose testing and endoscopy were repeated. Pair-wise comparisons of urine sucrose concentration were made between horses with induced ulcers before and after omeprazole treatment. Urine sucrose concentrations also were compared on the basis of ulcer severity score. Results: Urine sucrose concentrations and ulcer severity scores were significantly higher in horses with induced ulcers before omeprazole treatment than after treatment. Urine sucrose concentrations were significantly higher for horses with ulcer severity scores > 1. Use of a cut-point value of 0.7 mg/mL revealed that the apparent sensitivity and specificity of sucrose permeability testing to detect ulcers with severity scores > 1 was 83% and 90%, respectively. Results were similar after adjusting sucrose concentrations for urine osmolality. Conclusions: Urine sucrose concentration appears to be a reliable but imperfect indicator of gastric squamous ulcers in horses. Sucrose permeability testing may provide a simple, noninvasive test to detect and monitor gastric ulcers in horses.
Publication Date: 2004-01-15 PubMed ID: 14719699DOI: 10.2460/ajvr.2004.65.31Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Comparative Study
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The research paper focuses on the use of sucrose permeability testing to detect gastric squamous ulcers in horses. The results indicate that urine sucrose concentration provides a reliable but not infallible indicator of the presence of these ulcers, potentially offering a simpler and non-invasive alternative to traditional testing.
Research Methodology
- The study was carried out on 13 adult horses whose ages ranged from 5 to 19 years.
- Gastric ulcers were artificially induced in these horses by intermittent feed deprivation.
- Following this, the horses were subjected to sucrose permeability testing, which involved administrating sucrose through nasogastric intubation and then collecting urine samples at 2 and 4 hours after intubation.
- Gastric endoscopy was also performed and squamous ulcers were assigned a severity score of 0 to 3 using a previously established scoring system.
- The horses then received omeprazole treatment for 21 days. After this treatment period, the sucrose testing and endoscopy procedures were repeated.
Findings
- It was found that the urine sucrose concentrations and ulcer severity scores were significantly higher in horses with induced ulcers before the omeprazole treatment than after.
- Also, urine sucrose concentrations were significantly higher in horses with ulcer severity scores higher than 1.
- By using a cut-point value of 0.7 mg/mL, it was revealed that the sensitivity and specificity of sucrose permeability testing to detect ulcers of severity score higher than 1, were 83% and 90% respectively.
- Even after adjusting sucrose concentrations for urine osmolality, the results remained consistent.
Conclusion
- The study concludes that urine sucrose concentration can be used as a reliable but imperfect indicator for detecting gastric squamous ulcers in horses.
- This suggests that sucrose permeability testing might offer a non-invasive, simple alternative method for detecting and monitoring gastric ulcers in horses.
Cite This Article
APA
O'Conner MS, Steiner JM, Roussel AJ, Williams DA, Meddings JB, Pipers F, Cohen ND.
(2004).
Evaluation of urine sucrose concentration for detection of gastric ulcers in horses.
Am J Vet Res, 65(1), 31-39.
https://doi.org/10.2460/ajvr.2004.65.31 Publication
Researcher Affiliations
- Department of Large Animal Medicine and Surgery, College of Veterinary Medicine, Texas A&M University, College Station, TX 77843, USA.
MeSH Terms
- Animals
- Anti-Ulcer Agents / pharmacology
- Chromatography, High Pressure Liquid
- Endoscopy
- Horse Diseases / diagnosis
- Horses / urine
- Omeprazole / pharmacology
- Osmolar Concentration
- Statistics, Nonparametric
- Stomach Ulcer / diagnosis
- Stomach Ulcer / urine
- Stomach Ulcer / veterinary
- Sucrose / urine
Citations
This article has been cited 5 times.- Vokes J, Lovett A, Sykes B. Equine Gastric Ulcer Syndrome: An Update on Current Knowledge. Animals (Basel) 2023 Apr 5;13(7).
- Hund A, Schaffer A, Dolezal M, Mascher H, Wittek T. Measuring sucrose in blood after oral administration to detect abomasal ulcers in calves. J Vet Diagn Invest 2019 Sep;31(5):737-741.
- Hewetson M, Sykes BW, Hallowell GD, Tulamo RM. Diagnostic accuracy of blood sucrose as a screening test for equine gastric ulcer syndrome (EGUS) in adult horses. Acta Vet Scand 2017 Mar 11;59(1):15.
- Sykes BW, Hewetson M, Hepburn RJ, Luthersson N, Tamzali Y. European College of Equine Internal Medicine Consensus Statement--Equine Gastric Ulcer Syndrome in Adult Horses. J Vet Intern Med 2015 Sep-Oct;29(5):1288-99.
- Nishita T, Anezaki R, Matsunaga K, Orito K, Kasuya T, Sakanoue H, Matsunaga A, Arishima K. Measurement of Carbonic Anhydrase I and II Isozymes in Feces as a Marker of Occult Blood in Horses with Intestinal Tract Bleeding. J Equine Sci 2013;24(4):57-62.
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