Exercise induced alterations in the serum muscle enzymes, erythrocyte potassium and plasma constituents following feed withdrawal or furosemide and sodium bicarbonate administration in the horse.
Abstract: Six thoroughbreds were used in each of three trials to examine the effect of potassium depletion on exercise-associated muscle damage. Horses were exercised after a control period (Treatment 1), a 72-hour fast (Treatment 2), and furosemide and sodium bicarbonate (Treatment 3). During the preexercise period, feed withdrawal for 72 hours caused decreases in body weight, plasma sodium, chloride, and serum calcium. There were no changes in plasma potassium, erythrocyte potassium, or serum creatine phosphokinase (CK) activity. Furosemide and sodium bicarbonate administration resulted in a decrease in plasma potassium, chloride, serum calcium, and magnesium in the pre-exercise period. Erythrocyte potassium and serum CK activity were unchanged. Body weight initially decreased following furosemide and sodium bicarbonate and then increased upon access to water. In all three treatment groups plasma sodium, potassium, L-lactate, serum calcium, and magnesium were increased immediately following exercise. There was a significant increase (P less than 0.05) in serum CK activity in the furosemide and sodium bicarbonate-treated horses compared to control and withholding feed treatment groups by 30 minutes following exercise. Erythrocyte potassium was decreased immediately following exercise in the furosemide and sodium bicarbonate group but not in the other treatment groups. Potassium depletion may play a role in exercise-induced muscle damage but could not be implicated as the sole cause of the serum CK activity increase in this study.
Publication Date: 1991-01-01 PubMed ID: 1850484DOI: 10.1111/j.1939-1676.1991.tb00929.xGoogle Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The research study examined the impact of potassium depletion on muscle damage, following exercise in horses. Three different treatment methods were used for this examination, namely, control period, a 72-hour fasting, and administering furosemide and sodium bicarbonate.
Research Methodology
- Six thoroughbreds were used across three trials, making it a study based on a total of eighteen horses.
- The trials had three different treatments: a control period where no intervention occurred (Treatment 1), a 72-hour fast which entailed withholding of feed (Treatment 2), and administration of furosemide and sodium bicarbonate (Treatment 3).
- Exercise routines were assigned to the horses following these treatment periods.
Results from the Study
- After withholding feed for 72 hours, there were observable decreases in body weight, plasma sodium, plasma chloride, and serum calcium. However, there were no changes recorded in plasma potassium, erythrocyte potassium, or serum creatine phosphokinase (CK) activity.
- Administration of furosemide and sodium bicarbonate resulted in a decrease in plasma potassium, chloride, serum calcium, and magnesium during the pre-exercise period. There was no change in erythrocyte potassium or serum CK activity. The body weight of horses first decreased and then increased after they had access to water.
- Following exercise, there were increases in plasma sodium, potassium, L-lactate, serum calcium, and magnesium observed across all three treatment groups.
- There was a significant increase in serum CK activity in the furosemide and sodium bicarbonate-treated horses compared to the other two groups, 30 minutes post-exercise.
- The furosemide and sodium bicarbonate group showed a decrease in erythrocyte potassium immediately following exercise, but this was not observed in the other treatment groups.
Conclusions Drawn
- Potassium depletion potentially impacts exercise-induced muscle damage in horses. However, it cannot be solely blamed for the increase in serum CK activity, as observed in this study.
Cite This Article
APA
Freestone JF, Gossett K, Carlson GP, Church G.
(1991).
Exercise induced alterations in the serum muscle enzymes, erythrocyte potassium and plasma constituents following feed withdrawal or furosemide and sodium bicarbonate administration in the horse.
J Vet Intern Med, 5(1), 40-46.
https://doi.org/10.1111/j.1939-1676.1991.tb00929.x Publication
Researcher Affiliations
- Department of Veterinary Clinical Sciences, School of Veterinary Medicine Louisiana State University, Baton Rouge 70803.
MeSH Terms
- Animals
- Aspartate Aminotransferases / blood
- Bicarbonates / pharmacology
- Creatine Kinase / blood
- Electrolytes / blood
- Erythrocytes / chemistry
- Female
- Food Deprivation / physiology
- Furosemide / pharmacology
- Horse Diseases / etiology
- Horses
- Lactates / blood
- Male
- Muscles / enzymology
- Physical Conditioning, Animal / adverse effects
- Potassium / blood
- Rhabdomyolysis / etiology
- Rhabdomyolysis / veterinary
- Sodium / pharmacology
- Sodium Bicarbonate
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