Factors that influence outcome in experimental osteoarthritis.
Abstract: Osteoarthritis (OA) is the most common joint disease but an effective pharmacological therapy has not been developed yet. To identify targets for treatment and ways to interfere with OA development and progression both spontaneous and induced OA models are still needed. In this narrative review it is discussed what variables can be identified that lead to variation in OA animal model studies. Literature was screened (Pubmed) with the following terms; OA animal models in combination with species, age, strain, gender/sex, housing, diet, fighting, circadian rhythm, transgenic. Relevant articles were selected and additional papers were searched for and read for specific subtopics. Studies with OA models are subject to a multitude of variables, stimuli and conditions that can influence the outcome of an animal experiment. Outcome will depend on amongst others; the model used, species and strain, age, gender, diet, housing conditions, circadian rhythm, timing of intervention, stress levels and activity. Variations in these variables can account for discrepancies between OA model experiments, intervention studies and conclusions. To improve OA animal model research, investigators should be aware of all the stimuli and conditions that can interfere with disease development and disease intervention and take these into account in their study design and execution.
Copyright © 2016 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
Publication Date: 2016-09-09 PubMed ID: 27616682DOI: 10.1016/j.joca.2016.09.005Google Scholar: Lookup
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- Journal Article
- Review
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- Non-U.S. Gov't
Summary
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The research article discusses the different factors that could potentially influence the results in experimental osteoarthritis (OA) studies conducted on animal models.
Research Methodology
This paper is a narrative review based on a thorough analysis of existing literature, specifically focusing on animal models used in osteoarthritis studies. The researchers conducted a systematic search of articles on Pubmed using specific terms such as species, age, strain, gender/sex, housing, diet, circadian rhythm, and transgenic in combination with OA animal models. From this search, they selected relevant articles and further identified additional papers related to subtopics of interest for detailed examination.
Variables Influencing Osteoarthritis Models
The study outlines that results from osteoarthritis models can be subject to a range of variables, stimuli, and conditions which can significantly influence the outcomes of the experiments. These include:
- Model used: The specific type of osteoarthritis model utilized in the study can significantly influence the outcome.
- Species and strain: Variations in different species and strains used can lead to discrepancies in results.
- Age and gender: The age and gender of the animal models can greatly impact the development and progression of OA, thus affecting the study outcomes.
- Diet and housing conditions: These environmental variables can affect disease progression and the effectiveness of interventions.
- Circadian rhythms, stress levels, and activity: These variables related to the biology and behavior of the animals can complicate the measurements and outcomes of the OA studies.
Implications for Future Research
Given the array of factors that can potentially influence the results of OA studies, the authors suggest that future researchers need to be aware of these stimuli and conditions that may interfere with the development of the disease and the effectiveness of interventions. By carefully considering and controlling these variables in their experimental design and execution, researchers can improve the accuracy and reliability of their results, making them more conducive to developing effective therapeutic strategies for osteoarthritis.
Cite This Article
APA
van der Kraan PM.
(2016).
Factors that influence outcome in experimental osteoarthritis.
Osteoarthritis Cartilage, 25(3), 369-375.
https://doi.org/10.1016/j.joca.2016.09.005 Publication
Researcher Affiliations
- Experimental Rheumatology, Radboudumc, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. Electronic address: peter.vanderkraan@radboudumc.nl.
MeSH Terms
- Age Factors
- Animals
- Disease Models, Animal
- Dogs
- Female
- Goats
- Guinea Pigs
- Horses
- Housing, Animal
- Humans
- Joints / anatomy & histology
- Male
- Mice
- Mice, Transgenic
- Osteoarthritis / drug therapy
- Rabbits
- Rats
- Sex Factors
- Sheep
- Species Specificity
- Treatment Outcome
Citations
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