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Genetic Control of Albumin Phenotypes in Horses.

Abstract: By means of a starch-gel technique suggested by Kristjansson, 3 albumin phenotypes A, AB and B are demonstrable in the serum of horses. As indicated by data on the inheritance of these phenotypes and by a gene-frequency analysis of the distribution of the phenotypes in 2 breeds of horses, the results are consistent with the interpretation that the 3 phenotypes are controlled by a pair of codominant, autosomal alleles. These 3 phenotypes can be diagnosed by examining either the albumin region or the post-albumin region of the gels. Hence, diagnosis in one region serves as an independent check on the other.
Publication Date: 1963-12-01 PubMed ID: 14120321DOI: 10.3181/00379727-114-28766Google Scholar: Lookup
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  • Journal Article

Summary

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This research paper explores the genetic control of three different albumin phenotypes found in horse serum. The results indicate that these three phenotypes are attributed to a pair of codominant, autosomal alleles.

Methodology and Phenotype Identification

  • Scientists utilized a starch-gel technique suggested by Kristjansson to identify three different albumin phenotypes, labelled as A, AB and B, in the serum of horses.
  • The albumin region or the post-albumin region of the gels were examined to diagnose these 3 phenotypes. The diagnosis in one region genetically validates the other, ensuring accuracy of the results.

Data Collection and Analysis

  • Data was collected on the inheritance of these phenotypes in horses.
  • A gene-frequency analysis was also performed on the distribution of the phenotypes in two different breeds of horses.
  • The data and gene-frequency distribution were then interpreted and analyzed.

Results and Conclusions

  • The results of the study suggest that the three albumin phenotypes are controlled by a pair of codominant, autosomal alleles. Codominant alleles are pairs of genes where both genes contribute to the phenotype, while autosomal refers to them being located on a non-sex chromosome.
  • The consistency of the results in the two different breeds studied provide further support for the interpretation.

Cite This Article

APA
STORMONT C, SUZUKI Y. (1963). Genetic Control of Albumin Phenotypes in Horses. Proc Soc Exp Biol Med, 114, 673-675. https://doi.org/10.3181/00379727-114-28766

Publication

ISSN: 0037-9727
NlmUniqueID: 7505892
Country: United States
Language: English
Volume: 114
Pages: 673-675

Researcher Affiliations

STORMONT, C
    SUZUKI, Y

      MeSH Terms

      • Albumins
      • Animals
      • Blood Protein Electrophoresis
      • Gene Expression Regulation
      • Genetics
      • Horses
      • Phenotype
      • Research
      • Serum Albumin

      Citations

      This article has been cited 7 times.
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        doi: 10.1093/genetics/56.3.353pubmed: 6052565google scholar: lookup
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        doi: 10.1136/jmg.3.3.198pubmed: 5971057google scholar: lookup
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        doi: 10.1186/BF03547860pubmed: 5720657google scholar: lookup
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        pubmed: 5388272
      7. Fateh-Moghadam A, Eisenburg J, Lamerz R. [Alloalbuminemia (double albuminemia)]. Klin Wochenschr 1969 Sep 15;47(18):976-84.
        doi: 10.1007/BF01498235pubmed: 4986487google scholar: lookup