Genetic markers for stallion fertility–lessons from humans and mice.
Abstract: Our knowledge on the many aspects of mammalian reproduction in general and equine reproduction in particular has greatly increased during the last 15 years. Advances in the understanding of the physiology, cell biology, and biochemistry of reproduction have facilitated genetic analyses of fertility. Currently, there are more than 200 genes known that are involved in the production of fertile sperm cells. The completion of a number of mammalian genome projects will aid in the investigation of these genes in different species. Great progress has been made in the understanding of genetic aberrations that lead to male infertility. Additionally, the first genetic mechanisms are being discovered that contribute to the quantitative variation of fertility traits in fertile male animals. As artificial insemination (AI) represents a widespread technology in horse breeding, semen quality traits may eventually become an additional selection criterion for breeding stallions. Current research activities try to identify genetic markers that correlate to these semen quality traits. Here, we will review the current state of genetic research in male fertility and offer some perspectives for future research in horses.
Publication Date: 2005-08-02 PubMed ID: 16054786DOI: 10.1016/j.anireprosci.2005.06.021Google Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
- Review
Summary
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This study explores the advancements in equine reproduction understanding through knowledge gained from genetic analyses, focusing on genes implicated in producing fertile sperm cells. It also highlights the use of artificial insemination technology in horse breeding and ongoing research aimed at finding genetic markers related to semen quality traits.
Progress in Understanding Mammalian Reproduction
- Over the past 15 years, research in mammalian reproduction, particularly in equine reproduction, has significantly enhanced awareness in this field.
- This new understanding is propelled by developments in physiology, cell biology, and biochemistry of reproduction that have made it simpler to conduct genetic analyses of fertility.
- The research acknowledges over 200 genes responsible for the production of fertile sperm cells.
- The completion of genome projects for several mammalian species is expected to facilitate investigation of these genes across different species.
Genetic Aberrations and Male Infertility
- The study mentions significant strides made in understanding the genetic abnormalities that cause male infertility.
- The first genetic mechanisms contributing to the varied fertility characteristics in fertile male creatures are starting to be discovered.
Artificial Insemination and Equine Breeding
- Artificial Insemination (AI) is heavily utilised in horse breeding, and semen quality traits may become an additional selection criterion for breeding stallions in the future.
- Current research is dedicated to finding genetic markers that correspond to semen quality traits, which will assist in this selection process.
Future Research Perspectives
- The abstract concludes with a look at prospective research, focusing on the ongoing push to further the understanding of male fertility through genetic research.
- Further studies are recommended in horses to not only deepen our comprehension of equine reproduction, but also contribute to the broader field of mammalian reproduction.
Cite This Article
APA
Leeb T, Sieme H, Töpfer-Petersen E.
(2005).
Genetic markers for stallion fertility–lessons from humans and mice.
Anim Reprod Sci, 89(1-4), 21-29.
https://doi.org/10.1016/j.anireprosci.2005.06.021 Publication
Researcher Affiliations
- Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Bünteweg 17p, 30559 Hannover, Germany. Tosso.Leeb@tiho-hannover.de
MeSH Terms
- Animals
- Breeding
- Fertility
- Genetic Markers
- Horses / physiology
- Humans
- Insemination, Artificial / veterinary
- Male
- Mice
- Reproduction
- Sex Determination Analysis / veterinary
- Sperm Motility
- Spermatogenesis
- Spermatozoa / growth & development
References
This article includes 58 references
Citations
This article has been cited 2 times.- Kurta K, Jeuthe H, Naboulsi R, de Koning DJ, Palaiokostas C. Seasonal and age-related changes in sperm quality of farmed arctic charr (Salvelinus alpinus). BMC Genomics 2023 Sep 4;24(1):519.
- Medica AJ, Lambourne S, Aitken RJ. Predicting the Outcome of Equine Artificial Inseminations Using Chilled Semen. Animals (Basel) 2023 Mar 30;13(7).
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