Genome-wide association study of osteochondrosis in the tarsocrural joint of Dutch Warmblood horses identifies susceptibility loci on chromosomes 3 and 10.
Abstract: Equine osteochondrosis is a developmental joint disease that is a significant source of morbidity affecting multiple breeds of horse. The genetic variants underlying osteochondrosis susceptibility have not been established. Here, we describe the results of a genome-wide association study of osteochondrosis using 90 cases and 111 controls from a population of Dutch Warmblood horses. We report putative associations between osteochondrosis and loci on chromosome 3 (BIEC2-808543; P = 5.03 × 10(-7) ) and chromosome 10 (BIEC2-121323; P = 2.62 × 10(-7) ).
© 2012 The Authors, Animal Genetics © 2012 Stichting International Foundation for Animal Genetics.
Publication Date: 2012-12-25 PubMed ID: 23278111DOI: 10.1111/age.12016Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research explores the genetic factors behind osteochondrosis, a joint condition in horses, specifically Dutch Warmblood horses. Researchers identified potential associations between the disease and genetic loci on two chromosomes.
Study Overview
- This research study focuses on the genetic factors contributing to equine osteochondrosis. This is a joint disease that affects various horse breeds, causing significant health problems. Specifically, the study investigates Dutch Warmblood horses.
- The aim of the study was to establish the genetic variants that increase susceptibility to osteochondrosis, as these have not been previously identified.
Methodology
- The primary method utilized for this research was a genome-wide association study (GWAS). This process involves studying a complete set of DNA, or genome, to pinpoint genetic variants associated with a particular disease.
- The research team used 90 cases (horses with osteochondrosis) and 111 controls (horses without the condition) from a population of Dutch Warmblood horses.
Findings
- After conducting the GWAS, the researchers identified significant associations between osteochondrosis and genetic loci (the specific locations of a gene or DNA sequence on a chromosome) on two chromosomes: chromosome 3 and chromosome 10.
- The locus on chromosome 3 is identified as BIEC2-808543, with a P-value of 5.03 × 10(-7). A low P-value suggests that the findings are statistically significant, meaning they are likely not due to chance.
- The locus on chromosome 10 is identified as BIEC2-121323, with a P-value of 2.62 × 10(-7). Again, the low P-value suggests that the association between this locus and osteochondrosis is not by chance.
Conclusion
- This study provides valuable evidence regarding the genetic susceptibility of horses to osteochondrosis.
- It identifies two specific loci on chromosomes 3 and 10 that could be associated with increased risk of developing this joint disease.
- Future work will be necessary to confirm these findings and advance understanding in this area.
Cite This Article
APA
Orr N, Hill EW, Gu J, Govindarajan P, Conroy J, van Grevenhof EM, Ducro BJ, van Arendonk JA, Knaap JH, van Weeren PR, Machugh DE, Ennis S, Brama PA.
(2012).
Genome-wide association study of osteochondrosis in the tarsocrural joint of Dutch Warmblood horses identifies susceptibility loci on chromosomes 3 and 10.
Anim Genet, 44(4), 408-412.
https://doi.org/10.1111/age.12016 Publication
Researcher Affiliations
- Animal Genomics Laboratory, School of Agriculture and Food Science, University College Dublin, Dublin, Ireland; Section of Veterinary Clinical Sciences, School of Veterinary Medicine, University College Dublin, Dublin, Ireland.
MeSH Terms
- Animals
- Breeding
- Chromosome Mapping / veterinary
- Chromosomes, Mammalian / genetics
- Female
- Genetic Loci / genetics
- Genetic Predisposition to Disease
- Genome-Wide Association Study / methods
- Genome-Wide Association Study / veterinary
- Genotype
- Haplotypes
- Horse Diseases / diagnostic imaging
- Horse Diseases / genetics
- Horses
- Joint Diseases / diagnostic imaging
- Joint Diseases / genetics
- Joint Diseases / veterinary
- Male
- Osteochondrosis / diagnostic imaging
- Osteochondrosis / genetics
- Osteochondrosis / veterinary
- Phenotype
- Polymorphism, Single Nucleotide
- Radiography
Citations
This article has been cited 7 times.- Šimon M, Kaić A, Potočnik K. Unveiling Genetic Potential for Equine Meat Production: A Bioinformatics Approach. Animals (Basel) 2024 Aug 22;14(16).
- Raudsepp T, Finno CJ, Bellone RR, Petersen JL. Ten years of the horse reference genome: insights into equine biology, domestication and population dynamics in the post-genome era. Anim Genet 2019 Dec;50(6):569-597.
- Velie BD, Solé M, Fegraeus KJ, Rosengren MK, Røed KH, Ihler CF, Strand E, Lindgren G. Genomic measures of inbreeding in the Norwegian-Swedish Coldblooded Trotter and their associations with known QTL for reproduction and health traits. Genet Sel Evol 2019 May 27;51(1):22.
- Lewczuk D, Bereznowski A, Hecold M, Frąszczak M, Ruść A, Korwin-Kossakowska A, Szyda J, Kamiński S. Differences between horse selection based on two forms of osteochondrosis in fetlock. J Appl Genet 2018 May;59(2):225-230.
- Sevane N, Dunner S, Boado A, Cañon J. Polymorphisms in ten candidate genes are associated with conformational and locomotive traits in Spanish Purebred horses. J Appl Genet 2017 Aug;58(3):355-361.
- McCoy AM, Beeson SK, Splan RK, Lykkjen S, Ralston SL, Mickelson JR, McCue ME. Identification and validation of risk loci for osteochondrosis in standardbreds. BMC Genomics 2016 Jan 12;17:41.
- Bates JT, Jacobs JC Jr, Shea KG, Oxford JT. Emerging genetic basis of osteochondritis dissecans. Clin Sports Med 2014 Apr;33(2):199-220.
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists
